Induction of antiviral gene expression by cyclosporine A, but not inhibition of cyclophilin A or B, contributes to its restriction of human coronavirus 229E infection in a lung epithelial cell line

Emerging Roles of Cyclophilin A in Regulating Viral Cloaking

(2022) John E. Mamatis et al.   Frontiers in Microbiology

Cyclosporine A Inhibits Viral Infection and Release as Well as Cytokine Production in Lung Cells by Three SARS-CoV-2 Variants

(2022) Claudio Fenizia et al.   Microbiology Spectrum

The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor

(2022) Emmanuelle V. LeBlanc et al.   Scientific Reports

A Bioinformatics Approach to Investigate Structural and Non-Structural Proteins in Human Coronaviruses

(2022) Vittoria Cicaloni et al.   Frontiers in Genetics

Effects of immunophilin inhibitors and non-immunosuppressive analogs on coronavirus replication in human infection models

(2022) Emilia J. Berthold et al.   Frontiers in Cellular and Infection Microbiology

SARS-CoV-2 non-structural protein 1 inhibits the interferon response by causing depletion of key host signaling factors.

(2021) Anil Kumar et al.   JOURNAL OF VIROLOGY

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections

(2021) Seoyun Yum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2 N Protein Targets TRIM25-Mediated RIG-I Activation to Suppress Innate Immunity

(2021) Gianni Gori Savellini et al.   Viruses-Basel

Remdesivir and Cyclosporine Synergistically Inhibit the Human Coronaviruses OC43 and SARS-CoV-2

(2021) Hsing-Yu Hsu et al.   Frontiers in Pharmacology

Inhibition of SARS-CoV-2 infection by the cyclophilin inhibitor Alisporivir (Debio 025)

(2020) Laurent Softic et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cyclophilin Inhibitors Restrict Middle East Respiratory Syndrome Coronavirus Via Interferon λ In Vitro And In Mice

(2020) Lucie Sauerhering et al.   EUROPEAN RESPIRATORY JOURNAL

Hepatitis C virus exploits cyclophilin A to evade PKR

(2020) Che C Colpitts et al.   eLife

SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production

(2020) Keli Chen et al.   Viruses-Basel

Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses

(2019) Daisuke Yamane et al.   Nature Microbiology

Adaptive mutations in replicase transmembrane subunits can counteract inhibition of equine arteritis virus RNA synthesis by cyclophilin inhibitors

(2019) Adriaan H. de Wilde et al.   JOURNAL OF VIROLOGY

IRF1 Maintains Optimal Constitutive Expression of Antiviral Genes and Regulates the Early Antiviral Response

(2019) Debasis Panda et al.   Frontiers in Immunology

Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication

(2019) Yue Ma-Lauer et al.   ANTIVIRAL RESEARCH

Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture

(2018) Adriaan H. de Wilde et al.   VIROLOGY

The Severe Acute Respiratory Syndrome Coronavirus Nucleocapsid Inhibits Type I Interferon Production by Interfering with TRIM25-Mediated RIG-I Ubiquitination

(2017) Yong Hu et al.   JOURNAL OF VIROLOGY

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model

(2017) Adriaan H. de Wilde et al.   VIRUS RESEARCH

Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

(2017) Wei Liu et al.   eLife

Discovery of cyclosporine A and its analogs as broad-spectrum anti-influenza drugs with a high in vitro genetic barrier of drug resistance

(2016) Chunlong Ma et al.   ANTIVIRAL RESEARCH

Cyclophilin and NS5A Inhibitors, but Not Other Anti-Hepatitis C Virus (HCV) Agents, Preclude HCV-Mediated Formation of Double-Membrane-Vesicle Viral Factories

(2015) Udayan Chatterji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiviral Effects of Cyclosporin A in Neonatal Mice With Rotavirus-Induced Diarrhea

(2015) Zigang Shen et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Genetic deficiency and polymorphisms of cyclophilin A reveal its essential role for Human Coronavirus 229E replication

(2015) Albrecht von Brunn et al.   Current Opinion in Virology

Cyclosporin A Inhibits the Propagation of Influenza Virus by Interfering with a Late Event in the Virus Life Cycle

(2015) Itsuki Hamamoto et al.   JAPANESE JOURNAL OF INFECTIOUS DISEASES

Inhibition of HCV Replication by Cyclophilin Antagonists Is Linked to Replication Fitness and Occurs by Inhibition of Membranous Web Formation

(2014) Vanesa Madan et al.   GASTROENTEROLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Human coronavirus NL63 replication is cyclophilin A-dependent and inhibited by non-immunosuppressive cyclosporine A-derivatives including Alisporivir

(2014) Javier Carbajo-Lozoya et al.   VIRUS RESEARCH

HIV-1 evades innate immune recognition through specific cofactor recruitment

(2013) Jane Rasaiyaah et al.   NATURE

The cyclophilin inhibitor SCY-635 suppresses viral replication and induces endogenous interferons in patients with chronic HCV genotype 1 infection

(2012) Sam Hopkins et al.   JOURNAL OF HEPATOLOGY

Cyclosporin A inhibits the replication of diverse coronaviruses

(2011) A. H. de Wilde et al.   JOURNAL OF GENERAL VIROLOGY

The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors

(2011) Susanne Pfefferle et al.   PLoS Pathogens

Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms

(2010) A. Quintas-Cardama et al.   BLOOD

Cyclosporin A inhibits hepatitis C virus replication and restores interferon-alpha expression in hepatocytes

(2010) J.-P. Liu et al.   Transplant Infectious Disease

Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein

(2009) M. Qing et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY