Article
Microbiology
Helena Codina, Irene Vieitez, Alicia Gutierrez-Valencia, Vasso Skouridou, Cristina Martinez, Lucia Patino, Mariluz Botero-Gallego, Maria Trujillo-Rodriguez, Ana Serna-Gallego, Esperanza Munoz-Muela, Maria M. Bobillo, Alexandre Perez, Jorge Julio Cabrera-Alvar, Manuel Crespo, Ciara K. O'Sullivan, Ezequiel Ruiz-Mateos, Eva Poveda
Summary: The kinetics of viral and host immune response during acute COVID-19 and after remission of symptoms require further characterization. Research has found that higher levels of antibodies and cytokines early on are associated with COVID-19 severity.
Review
Microbiology
Jakob J. Malin, Isabelle Suarez, Vanessa Priesner, Gerd Fatkenheuer, Jan Rybniker
Summary: Remdesivir is the first approved treatment for COVID-19, showing therapeutic and prophylactic effects in animal models of various viruses. However, it failed in a clinical trial on ebolavirus disease but showed beneficial effects for patients with COVID-19 in a placebo-controlled trial.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Immunology
Marina Luise Viola Azevedo, Aline Cristina Zanchettin, Caroline Busatta Vaz de Paula, Jarbas da Silva Motta Junior, Mineia Alessandra Scaranello Malaquias, Sonia Mara Raboni, Plinio Cezar Neto, Rafaela Chiuco Zeni, Amanda Prokopenko, Nicolas Henrique Borges, Thiago Mateus Godoy, Ana Paula Kubaski Benevides, Daiane Gavlik de Souza, Cristina Pellegrino Baena, Cleber Machado-Souza, Lucia de Noronha
Summary: By comparing post-mortem lung samples from patients who died of severe COVID-19 and H1N1pdm09 infection, it was found that the H1N1 group showed an increase in tissue expression of IL-8/IL-17A and a higher number of neutrophils. There was no significant difference in the distribution of genotype frequencies in the IL17A gene between the two groups. However, in SNP rs3819025 (G/A), the G allele may be considered a risk allele in patients who died from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Matthew J. McConnell, Nao Kawaguchi, Reiichiro Kondo, Aurelio Sonzogni, Lisa Licini, Clarissa Valle, Pietro A. Bonaffini, Sandro Sironi, Maria Grazia Alessio, Giulia Previtali, Michela Seghezzi, Xuchen Zhang, Alfred Lee, Alexander B. Pine, Hyung J. Chun, Xinbo Zhang, Carlos Fernandez-Hernando, Hua Qing, Andrew Wang, Christina Price, Zhaoli Sun, Teruo Utsumi, John Hwa, Mario Strazzabosco, Yasuko Iwakiri
Summary: Analysis of COVID-19 patients suggests that IL-6 trans-signaling may cause hepatic endotheliopathy and blood clot formation, leading to liver injury.
JOURNAL OF HEPATOLOGY
(2021)
Article
Microbiology
Muneerah M. Aleissa, Emily A. Silverman, Luisa M. Paredes Acosta, Cameron T. Nutt, Aaron Richterman, Francisco M. Marty
Summary: Remdesivir has been approved for treating hospitalized patients with COVID-19, showing improved survival rates and decreased viral RNA levels when used early in the course of the disease.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
M. Gabriella Santoro, Ernesto Carafoli
Summary: Human coronaviruses were initially thought to cause mild respiratory diseases, but challenges came with the SARS and MERS outbreaks. Remdesivir, originally developed for Ebola, has shown potential in treating SARS-CoV-2, with some trials showing positive results while others have been negative.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Xiaoqi Zhou, Guangming Ye, Yibing Lv, Yanyan Guo, Xingfei Pan, Yirong Li, Guanxin Shen, Yong He, Ping Lei
Summary: Lymphopenia, particularly the reduction of CD4(+) T cells, is a reliable indicator of severity and hospitalization in COVID-19 patients. CD4(+) T cell count below 200 cells/mu L predicts critical illness. IL-6, which possibly correlates inversely with T cell counts, can induce T cell reduction through gasderminE-mediated pyroptosis, suggesting its involvement in affecting the function and status of T cells in COVID-19 patients. Intervening IL-6-mediated T cell pyroptosis may effectively delay disease progression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pediatrics
Ana Mendez-Echevarria, Antonio Perez-Martinez, Luis Gonzalez del Valle, Maria Fatima Ara, Susana Melendo, Marta Ruiz de Valbuena, Jose Luis Vazquez-Martinez, Antonio Morales-Martinez, Agustin Remesal, Kinga Amalia Sandor-Bajusz, Fernando Cabanas, Cristina Calvo
Summary: A clinical study in Spain reported successful clinical outcomes in most children treated with RDV, highlighting the need for clinical trials to evaluate the efficacy and safety of RDV in children with COVID-19.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pharmacology & Pharmacy
Erik De Clercq
Summary: Remdesivir is the only antiviral drug formally approved by the US FDA for the treatment of Covid-19. Its key structural features and mode of action have been well established, but further optimization in clinical application is needed in terms of dosage, timing, route of administration, and potential combinations with other drugs for efficacy evaluation.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Robert Flisiak, Jerzy Jaroszewicz, Magdalena Rogalska, Tadeusz Lapinski, Aleksandra Berkan-Kawinska, Beata Bolewska, Magdalena Tudrujek-Zdunek, Dorota Kozielewicz, Marta Rorat, Piotr Leszczynski, Krzysztof Klos, Justyna Kowalska, Pawel Pabjan, Anna Piekarska, Iwona Mozer-Lisewska, Krzysztof Tomasiewicz, Malgorzata Pawlowska, Krzysztof Simon, Joanna Polanska, Dorota Zarebska-Michaluk
Summary: The study demonstrated the significant impact of tocilizumab on reducing mortality and accelerating clinical improvement in COVID-19 patients with a baseline concentration of IL-6 > 100 pg/mL, particularly those who require oxygen supplementation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
Tomoyuki Yamaguchi, Toshie Shinagawa, Hisanobu Kobata, Hidemitsu Nakagawa
Summary: This study found that producing antibodies against OC43 in COVID-19 patients can effectively prevent severe or fatal pneumonia. There was no significant difference in antibody titres against SARS-CoV-2 and OC43 between severe and mild COVID-19 patients. Antibody production against OC43 was stronger than that against SARS-CoV-2 in the early stages of COVID-19.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Jian Wu, Jiawei Shen, Ying Han, Qinghua Qiao, Wei Dai, Bangshun He, Rongrong Pang, Jun Zhao, Tao Luo, Yanju Guo, Yang Yang, Qiuyue Wu, Weijun Jiang, Jing Zhang, Mingchao Zhang, Na Li, Weiwei Li, Xinyi Xia
Summary: IL-6 levels are closely linked to various indicators and prognosis in COVID-19 patients, serving as a stable marker for inflammation. Treatments like tocilizumab and convalescent plasma therapy can reduce IL-6 levels, alleviate inflammation, and are particularly effective for critically ill patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Bogusz Jan Aksak-Was, Daniel Chober, Karol Serwin, Kaja Scheibe, Jolanta Niscigorska-Olsen, Anna Niedzwiedz, Monika Dobrowolska, Katarzyna Zybul, Marta Kubacka, Agnieszka Zimon, Ewa Holda, Joanna Miezynska-Kurtycz, Marta Gryczman, Grzegorz Jamro, Pawel Szakola, Milosz Parczewski
Summary: Remdesivir significantly reduces early mortality in COVID-19 patients, but its efficacy in patients with hematologic oncological diseases needs further investigation.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Jessica M. Conway, Pia Abel zur Wiesch
Summary: The antiviral drug remdesivir has been approved for treating COVID-19 by regulatory bodies, but its efficacy and toxicity concerns have sparked debates. Computational models are being used to predict drug efficacy and balancing it with toxicity, particularly due to the complexities of its metabolization. Studies suggest that optimizing dosing regimens and combining remdesivir with other antivirals could potentially enhance efficacy and prevent resistance.
Article
Allergy
Li-An K. Brown, Ed Moran, Anna Goodman, Helen Baxendale, William Bermingham, Matthew Buckland, Iman AbdulKhaliq, Hannah Jarvis, Michael Hunter, Surendra Karanam, Aisha Patel, Megan Jenkins, Alexander Robbins, Sujoy Khan, Thomas Simpson, Stephen Jolles, Jonathan Underwood, Sinisa Savic, Alex Richter, Adrian Shields, Michael Brown, David M. Lowe
Summary: This study characterized a cohort of patients with chronic or relapsing COVID-19 disease who have immunodeficiency. The findings suggest that remdesivir monotherapy is often ineffective, but the combination of remdesivir with antibody-based therapeutics shows promise.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Hematology
Binay K. Sahoo, Yuh-Charn Lin, Cheng-Fen Tu, Wei-Ju Liao, Ling -Hui Li, Kurt Yun Mou, Shu-Ping Wang, Chi-Tai Yeh, Chi-Yuan Yao, Hsin-An Hou, Wen -Chien Chou, Hwei-Fang Tien, Ruey-Bing Yang
Summary: A hallmark of MLL-r acute myeloid leukemia is addiction to protein tyrosine kinase signaling, particularly FLT3 signaling. This study reveals that SCUBE1 is a direct target of HOXA9/MEIS1 and is highly expressed on the MLL-r cell surface. SCUBE1 binds to both the FLT3 ligand and the extracellular ligand-binding domains of FLT3, facilitating activation of the FLT3-LYN signaling axis. Targeting surface SCUBE1 with an antibody-drug conjugate leads to decreased cell viability specifically in MLL-r leukemia. SCUBE1 is a potential therapeutic target for MLL rearrangement-induced leukemia.
Letter
Immunology
Chen-An Chao, Yi-Fu Lin, Tai-Fen Lee, Shang-Ju Wu, Kai-Hsiang Chen, Yi-Ching Su, Kuan-Yin Lin, Sui-Yuan Chang, Chien-Ching Hung
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Immunology
Tai-fen Lee, Kuan-Yin Lin, Sui-Yuan Chang, Yu-Tsung Huang, Po-Ren Hsueh
Summary: This study aimed to investigate the etiologies of sexually transmitted infections (STIs) among men who have sex with men (MSM) in Taiwan. Two commercial assays were used for evaluation and revealed high rates of STI-associated etiologies in MSM, with higher positivity rates in rectal swabs than in urine samples.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Biochemistry & Molecular Biology
Yu-Ting Hsieh, Tsung-Lin Tsai, Shen-Yan Huang, Jian-Wen Heng, Yu-Chia Huang, Pei-Yuan Tsai, Chia-Chun Tu, Tai-Ling Chao, Ya-Min Tsai, Pei-Ching Chang, Chien-Kuo Lee, Guann-Yi Yu, Sui-Yuan Chang, Ivan L. L. Dzhagalov, Chia-Lin Hsu
Summary: A growing body of evidence highlights the role of metabolic reprogramming in immune cells to combat infections. However, the regulation of metabolite transporters that support metabolic demands remains poorly understood. This study demonstrates that equilibrative nucleoside transporter 3 (ENT3) is part of the innate immune response and is upregulated upon pathogen invasion. The expression of ENT3 is directly regulated by type I interferon-induced signaling and is required for the entry and replication of several viruses, including SARS-CoV-2.
Article
Medicine, General & Internal
Wang-Da Liu, Jann-Tay Wang, Tai-Ling Chao, Si-Man Ieong, Ya-Min Tsai, Po-Hsien Kuo, Ming-Jui Tsai, Yi-Jie Chen, Guei-Chi Li, Shu-Yuan Ho, Hui-Hou Chen, Yu-Shan Huang, Chien-Ching Hung, Yee-Chun Chen, Sui-Yuan Chang, Shan-Chwen Chang
Summary: Patients recovering from COVID-19 may experience a decline in acquired immunity within 4-7 months, and the neutralizing activity against different SARS-CoV-2 variants may be lower compared to the wild-type strain.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Correction
Pharmacology & Pharmacy
Yue-Zhi Lee, Hsing-Yu Hsu, Cheng-Wei Yang, Yi-Ling Lin, Sui-Yuan Chang, Ruey-Bing Yang, Jian-Jong Liang, Tai-Ling Chao, Chun-Che Liao, Han-Chieh Kao, Jang-Yang Chang, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow-Ju Lee
Article
Plant Sciences
Osbert Chou, Yu-Pu Juang, Tai-Ling Chao, Sheng-Fa Tsai, Pei-Fang Chiu, Chun-Tang Chiou, Keng-Chang Tsai, Sui-Yuan Chang, Pi-Hui Liang, Chi-Huey Wong
Summary: Traditional herbal medicine was explored for potential therapeutics against SARS-CoV-2 mutation. Mint (Mentha canadensis L.) was selected for bioactivity-guided extraction, resulting in the isolation and characterization of seven constituents. Syringic acid and methyl rosmarinate showed promising results in drug combination treatment. Synthetic derivatives of methyl rosmarinate demonstrated significantly improved antiviral activity against Omicron BA.1 compared to methyl rosmarinate alone.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Microbiology
Hui-Ying Ko, Yao-Tsun Li, Ya-Yuan Li, Ming-Tsai Chiang, Yi-Ling Lee, Wen-Chun Liu, Chun-Che Liao, Chih-Shin Chang, Yi-Ling Lin
Summary: COVID-19 is a major global public health threat, and RT-qPCR is used for viral RNA detection. Saliva has been suggested as a practical alternative to nasopharyngeal swabs for viral RNA detection. This study evaluated the effect of saliva on viral RNA detection and found that saliva increased the C-T values of SARS-CoV-2 RNA samples compared to viral transport medium.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Tai-Ling Chao, Wen-Hau Lee, Hui-Chun Hu, Yi-Chun Lind, Shu-Yuan Ho, Hui-Hou Chene, Cheng-Pin Chen, Ya-Min Tsai, Jun-Tung Fang, Si-Man Leong, Yu-Chen Chenga, Mavis Penga, Shu-Hsing Chengd, Chien-Yu Cheng, Sui-Yuan Chang
Summary: This study examined the performance of the Vstrip(R) RV2 COVID-19 Antigen Rapid Test (RAT) and its correlation with virus infectivity through virus culture. The RAT showed a sensitivity of 96.43%, specificity of 89.63%, and high consistency with virus culture results when the Ct values of specimens were below 25. It can be considered as a great alternative method for determining the infectious potential of individuals with high viral load.
JOURNAL OF CLINICAL VIROLOGY PLUS
(2023)
Article
Pharmacology & Pharmacy
Srinivasa Rao Palla, Chen-Wei Li, Tai-Ling Chao, Hoi-Ling Vienn Lob, Jia-Jin Liu, Max Yu-Chen Pane, Yu-Ting Chiu, Wen-Chin Lin, Chih-Wei Hu, Chuen-Mi Yangf, Yi-Ying Chen, Jun-Tung Fang, Sheng-Wei Lin, Yi-Tzu Lin, Hsiao-Ching Lin, Chih-Jung Kuo, Lily Hui-Ching Wang, Sui-Yuan Chang, Po-Huang Liang
Summary: Newly synthesized compounds were found to inhibit the entry of SARS-CoV-2 by targeting proteases and the interaction between Spike protein and ACE2. The most potent compound showed strong antiviral activity, inhibiting various SARS-CoV-2 variants in cell cultures and reducing viral RNA levels in animal models. These findings highlight the potential of the lead compound as a treatment for SARS-CoV-2.
ANTIVIRAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Cheng-Wei Yang, Hsing-Yu Hsu, Yue-Zhi Lee, Jia-Tsrong Jan, Sui-Yuan Chang, Yi-Ling Lin, Ruey-Bing Yang, Tai-Ling Chao, Jian-Jong Liang, Shu-Jing Lin, Chun-Che Liao, Chih-Shin Chang, Huey-Kang Sytwu, Ming-Shiu Hung, Chiung-Tong Chen, Shiow-Ju Lee
Summary: Four natural fucoidans extracted from different types of seaweed demonstrated strong inhibition against HCoV-OC43 infection, with EC50 values ranging from 0.15 to 0.61 μg/mL. The fucoidan extracted from Undaria pinnatifida showed the highest anti-HCoV-OC43 activity, independent of its sulfate content. Fucoidan treatment effectively reduced the expression of genes associated with chemokines, cytokines, and viral activities.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Cell Biology
Yuh-Charn Lin, Binay K. Sahoo, Shiang-Shin Gau, Ruey-Bing Yang
Summary: The SCUBE family consists of three highly conserved proteins in vertebrates that play important roles in various physiological and pathological processes. Both soluble and membrane-associated SCUBEs are involved in signaling pathways and have been implicated in cancer, skeletal disease, and cardiovascular disease.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)