Plasmodium falciparum GCN5 plays a key role in regulating artemisinin resistance-related stress responses

Characterization of the dual role of Plasmodium falciparum DNA methyltransferase in regulating transcription and translation

(2023) Amuza B Lucky et al.   NUCLEIC ACIDS RESEARCH

Glucose starvation induces a switch in the histone acetylome for activation of gluconeogenic and fat metabolism genes

(2022) Wen-Chuan Hsieh et al.   MOLECULAR CELL

A Leak-Free Inducible CRISPRi/a System for Gene Functional Studies in Plasmodium falciparum

(2022) Xiaoying Liang et al.   Microbiology Spectrum

Emerging biology of noncoding RNAs in malaria parasites

(2022) Karina Simantov et al.   PLoS Pathogens

Epigenetic and Epitranscriptomic Gene Regulation in Plasmodium falciparum and How We Can Use It against Malaria

(2022) Rafael Serrano-Durán et al.   Genes

A transcriptional switch controls sex determination in Plasmodium falciparum

(2022) A. R. Gomes et al.   NATURE

Epitranscriptomics in parasitic protists: Role of RNA chemical modifications in posttranscriptional gene regulation

(2022) Cassandra Catacalos et al.   PLoS Pathogens

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

(2021) Sachel Mok et al.   Nature Communications

Histone acetyltransferase PfGCN5 regulates stress responsive and artemisinin resistance related genes in Plasmodium falciparum

(2021) Mukul Rawat et al.   Scientific Reports

Full-Length Transcriptome Analysis of Plasmodium falciparum by Single-Molecule Long-Read Sequencing

(2021) Mengquan Yang et al.   Frontiers in Cellular and Infection Microbiology

Updated Mechanisms of GCN5—The Monkey King of the Plant Kingdom in Plant Development and Resistance to Abiotic Stresses

(2021) Lei Gan et al.   Cells

Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites

(2021) Emily S. Mathews et al.   mBio

The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite

(2021) Min Zhang et al.   Nature Communications

A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum

(2021) Jun Miao et al.   PLoS Pathogens

A heat-shock response regulated by the PfAP2-HS transcription factor protects human malaria parasites from febrile temperatures

(2021) Elisabet Tintó-Font et al.   Nature Microbiology

Role of PfGCN5 in nutrient sensing and transcriptional regulation in Plasmodium falciparum

(2020) Mukul Rawat et al.   JOURNAL OF BIOSCIENCES

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

Role of Plasmodium falciparum Kelch 13 Protein Mutations in P. falciparum Populations from Northeastern Myanmar in Mediating Artemisinin Resistance

(2020) Faiza Amber Siddiqui et al.   mBio

Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria

(2020) Dipak K. Raj et al.   NATURE

Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq

(2020) Lia Chappell et al.   BMC GENOMICS

‘Artemisinin Resistance’: Something New or Old? Something of a Misnomer?

(2020) Thomas E. Wellems et al.   TRENDS IN PARASITOLOGY

GCN5 acetyltransferase in cellular energetic and metabolic processes

(2020) Beste Mutlu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

(2020) Kuan-Yi Lu et al.   eLife

Exported plasmodial J domain protein, PFE0055c, and PfHsp70-x form a specific co-chaperone-chaperone partnership

(2020) Tanima Dutta et al.   CELL STRESS & CHAPERONES

Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences

(2020) Jingyi Tang et al.   Epigenetics & Chromatin

Genetic background and PfKelch13 affect artemisinin susceptibility of PfCoronin mutants in Plasmodium falciparum

(2020) Aabha I. Sharma et al.   PLoS Genetics

The ER chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites

(2019) Heather M. Kudyba et al.   CELLULAR MICROBIOLOGY

The molecular machinery of translational control in malaria parasites

(2019) Sandra Bennink et al.   MOLECULAR MICROBIOLOGY

The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite

(2019) Jemma Day et al.   FASEB JOURNAL

Plasmodium falciparum GCN5 acetyltransferase follows a novel proteolytic processing pathway that is essential for its function

(2019) Krishanu Bhowmick et al.   JOURNAL OF CELL SCIENCE

Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance

(2018) Faiza A Siddiqui et al.   JOURNAL OF INFECTIOUS DISEASES

GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing

(2018) Michael Filarsky et al.   SCIENCE

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

(2018) Frances Rocamora et al.   PLoS Pathogens

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

(2018) Jessica L. Bridgford et al.   Nature Communications

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites

(2018) Michael J. Boucher et al.   PLOS BIOLOGY

Dihydroartemisinin–Ferriprotoporphyrin IX Adduct Abundance in Plasmodium falciparum Malarial Parasites and the Relationship to Emerging Artemisinin Resistance

(2018) Laura E. Heller et al.   BIOCHEMISTRY

Human erythrocyte band 3 is a host receptor for Plasmodium falciparum glutamic acid-rich protein

(2018) Haifa Almukadi et al.   BLOOD

Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility

(2018) Allison R. Demas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Degradation Systems as Antimalarial Therapeutic Targets

(2017) Caroline L. Ng et al.   TRENDS IN PARASITOLOGY

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

(2017) Judith Straimer et al.   mBio

Expansion of Lysine-rich Repeats inPlasmodiumProteins Generates Novel Localization Sequences That Target the Periphery of the Host Erythrocyte

(2016) Heledd M. Davies et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arbitrarily Accessible 3D Microfluidic Device for Combinatorial High-Throughput Drug Screening

(2016) Zhuofa Chen et al.   SENSORS

Synthetic RNA–protein modules integrated with native translation mechanisms to control gene expression in malaria parasites

(2016) Suresh M. Ganesan et al.   Nature Communications

DNA damage regulation and its role in drug-related phenotypes in the malaria parasites

(2016) Devendra Kumar Gupta et al.   Scientific Reports

Translational regulation in blood stages of the malaria parasite Plasmodium spp. : systems-wide studies pave the way

(2016) Shruthi Sridhar Vembar et al.   Wiley Interdisciplinary Reviews-RNA

Artemisinin Resistance at the China-Myanmar Border and Association with Mutations in the K13 Propeller Gene

(2015) Zenglei Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Gcn5 Modulates the Cellular Response to Oxidative Stress and Histone Deacetylase Inhibition

(2015) Ann-Christin Gaupel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis

(2015) Zhaorong Hu et al.   PLANT JOURNAL

Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species

(2014) Anusha M. Gopalakrishnan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

Versatile control of Plasmodium falciparum gene expression with an inducible protein–RNA interaction

(2014) Stephen J. Goldfless et al.   Nature Communications

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

(2013) Nectarios Klonis et al.   CURRENT OPINION IN MICROBIOLOGY

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

(2013) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

Mechanisms ofin vitroresistance to dihydroartemisinin inPlasmodium falciparum

(2012) Long Cui et al.   MOLECULAR MICROBIOLOGY

Plasmodium falciparum  heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers

(2012) Vasant Muralidharan et al.   Nature Communications

The proteasome of malaria parasites: A multi-stage drug target for chemotherapeutic intervention?

(2012) Makoah Nigel Aminake et al.   International Journal for Parasitology-Drugs and Drug Resistance

Phenotypic Changes in Artemisinin-Resistant Plasmodium falciparum LinesIn Vitro: Evidence for Decreased Sensitivity to Dormancy and Growth Inhibition

(2011) Franka Teuscher et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phenotypic and Genotypic Analysis ofIn Vitro-Selected Artemisinin-Resistant Progeny of Plasmodium falciparum

(2011) Matthew S. Tucker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Rapid isolation of single malaria parasite–infected red blood cells by cell sorting

(2011) Jun Miao et al.   Nature Protocols

Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism

(2010) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles

(2010) Yongtao Xue-Franzén et al.   BMC GENOMICS

The Puf-family RNA-binding protein PfPuf2 regulates sexual development and sex differentiation in the malaria parasite Plasmodium falciparum

(2010) J. Miao et al.   JOURNAL OF CELL SCIENCE

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

Toxoplasma gondii Lysine Acetyltransferase GCN5-A Functions in the Cellular Response to Alkaline Stress and Expression of Cyst Genes

(2010) Arunasalam Naguleswaran et al.   PLoS Pathogens

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY