A heat-shock response regulated by the PfAP2-HS transcription factor protects human malaria parasites from febrile temperatures

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

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Dissecting the role of PfAP2-G in malaria gametocytogenesis

(2020) Gabrielle A. Josling et al.   Nature Communications

Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum

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Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

(2020) Kuan-Yi Lu et al.   eLife

Artemisinin exposure at the ring or trophozoite stage impacts Plasmodium falciparum sexual conversion differently

(2020) Harvie P Portugaliza et al.   eLife

The ER chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites

(2019) Heather M. Kudyba et al.   CELLULAR MICROBIOLOGY

ApiAP2 Transcription Factors in Apicomplexan Parasites

(2019) Myriam Jeninga et al.   Pathogens

Drug resistance in Plasmodium

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Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

(2018) Jessica L. Bridgford et al.   Nature Communications

Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum

(2018) Cristina Bancells et al.   Nature Microbiology

Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

(2017) Benjamin Blasco et al.   NATURE MEDICINE

Regulation of heat shock transcription factors and their roles in physiology and disease

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Generating conditional gene knockouts in Plasmodium – a toolkit to produce stable DiCre recombinase-expressing parasite lines using CRISPR/Cas9

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Culture adaptation of malaria parasites selects for convergent loss-of-function mutants

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Malaria Pathogenesis

(2017) Danny A. Milner   Cold Spring Harbor Perspectives in Medicine

Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation

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Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis

(2016) Eric J. Solís et al.   MOLECULAR CELL

New Assays to Characterise Growth-Related Phenotypes of Plasmodium falciparum Reveal Variation in Density-Dependent Growth Inhibition between Parasite Lines

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UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

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The unpredictability of prolonged activation of stress response pathways

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Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

A transcriptional switch underlies commitment to sexual development in malaria parasites

(2014) Björn F. C. Kafsack et al.   NATURE

Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system

(2014) Mehdi Ghorbal et al.   NATURE BIOTECHNOLOGY

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Blocking Plasmodium falciparum Development via Dual Inhibition of Hemoglobin Degradation and the Ubiquitin Proteasome System by MG132

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Transcriptional variation in the malaria parasite Plasmodium falciparum

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New Agilent platform DNA microarrays for transcriptome analysis of Plasmodium falciparum and Plasmodium berghei for the malaria research community

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Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

(2012) Magnus Manske et al.   NATURE

Plasmodium falciparum  heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers

(2012) Vasant Muralidharan et al.   Nature Communications

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

Heterochromatin formation in bistable chromatin domains controls the epigenetic repression of clonally variant Plasmodium falciparum genes linked to erythrocyte invasion

(2011) Valerie M. Crowley et al.   MOLECULAR MICROBIOLOGY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Clinical and molecular aspects of malaria fever

(2011) Miranda S. Oakley et al.   TRENDS IN PARASITOLOGY

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Identification and Genome-Wide Prediction of DNA Binding Specificities for the ApiAP2 Family of Regulators from the Malaria Parasite

(2010) Tracey L. Campbell et al.   PLoS Pathogens

Post-translational events of a model reporter protein proceed with higher fidelity and accuracy upon mild hypothermic culturing of Chinese hamster ovary cells

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Structural Determinants of DNA Binding by a P. falciparum ApiAP2 Transcriptional Regulator

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Statistical estimation of cell-cycle progression and lineage commitment in Plasmodium falciparum reveals a homogeneous pattern of transcription in ex vivo culture

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Ontologizer 2.0--a multifunctional tool for GO term enrichment analysis and data exploration

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Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY