Power of inclusion: Enhancing polygenic prediction with admixed individuals

Significance tests for R2 of out-of-sample prediction using polygenic scores

(2023) Md. Moksedul Momin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Fast and accurate Bayesian polygenic risk modeling with variational inference

(2023) Shadi Zabad et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Polygenic scoring accuracy varies across the genetic ancestry continuum

(2023) Yi Ding et al.   NATURE

Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals

(2023) Kangcheng Hou et al.   NATURE GENETICS

Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies

(2023) Pouria Salehi Nowbandegani et al.   NATURE GENETICS

Improving polygenic prediction in ancestrally diverse populations

(2022) Yunfeng Ruan et al.   NATURE GENETICS

Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores

(2022) Omer Weissbrod et al.   NATURE GENETICS

Significant sparse polygenic risk scores across 813 traits in UK Biobank

(2022) Yosuke Tanigawa et al.   PLoS Genetics

Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association

(2022) Jack W. O’Sullivan et al.   CIRCULATION

Including diverse and admixed populations in genetic epidemiology research

(2022) Amke Caliebe et al.   GENETIC EPIDEMIOLOGY

Increasing diversity in genomics requires investment in equitable partnerships and capacity building

(2022) Alicia R. Martin et al.   NATURE GENETICS

Glaucoma genetic risk scores in the Million Veteran Program

(2022) Andrea R. Waksmunski et al.   OPHTHALMOLOGY

Large-scale multivariate sparse regression with applications to UK Biobank

(2022) Junyang Qian et al.   Annals of Applied Statistics

A saturated map of common genetic variants associated with human height

(2022) Loïc Yengo et al.   NATURE

Genetics of 35 blood and urine biomarkers in the UK Biobank

(2021) Nasa Sinnott-Armstrong et al.   NATURE GENETICS

Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power

(2021) Elizabeth G. Atkinson et al.   NATURE GENETICS

African genetic diversity and adaptation inform a precision medicine agenda

(2021) Luisa Pereira et al.   NATURE REVIEWS GENETICS

Survival Analysis on Rare Events Using Group-Regularized Multi-Response Cox Regression

(2021) Ruilin Li et al.   BIOINFORMATICS

Improving reporting standards for polygenic scores in risk prediction studies

(2021) Hannah Wand et al.   NATURE

The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation

(2021) Samuel A. Lambert et al.   NATURE GENETICS

Population-specific causal disease effect sizes in functionally important regions impacted by selection

(2021) Huwenbo Shi et al.   Nature Communications

Fast numerical optimization for genome sequencing data in population biobanks

(2021) Ruilin Li et al.   BIOINFORMATICS

Computationally efficient whole-genome regression for quantitative and binary traits

(2021) Joelle Mbatchou et al.   NATURE GENETICS

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

(2020) Davide Marnetto et al.   Nature Communications

Polygenic risk scores: from research tools to clinical instruments

(2020) Cathryn M. Lewis et al.   Genome Medicine

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma

(2020) Yosuke Tanigawa et al.   PLoS Genetics

Fast Lasso method for large-scale and ultrahigh-dimensional Cox model with applications to UK Biobank

(2020) Ruilin Li et al.   BIOSTATISTICS

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

(2020) Ming-Huei Chen et al.   CELL

Polygenic Scores for Height in Admixed Populations

(2020) Bárbara D. Bitarello et al.   G3-Genes Genomes Genetics

A fast and scalable framework for large-scale and ultrahigh-dimensional sparse regression with application to the UK Biobank

(2020) Junyang Qian et al.   PLoS Genetics

Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements

(2020) Tiffany Amariuta et al.   NATURE GENETICS

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

Genomics of disease risk in globally diverse populations

(2019) Deepti Gurdasani et al.   NATURE REVIEWS GENETICS

Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology

(2019) Yosuke Tanigawa et al.   Nature Communications

Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study

(2018) Christopher DeBoever et al.   Nature Communications

Global Biobank Engine: enabling genotype-phenotype browsing for biobank summary statistics

(2018) Gregory McInnes et al.   BIOINFORMATICS

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Multiethnic polygenic risk scores improve risk prediction in diverse populations

(2017) Carla Márquez-Luna et al.   GENETIC EPIDEMIOLOGY

Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia

(2016) Kevin J. Galinsky et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Second-generation PLINK: rising to the challenge of larger and richer datasets

(2015) Christopher C Chang et al.   GigaScience

Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences

(2014) Vincenza Colonna et al.   GENOME BIOLOGY

RFMix: A Discriminative Modeling Approach for Rapid and Robust Local-Ancestry Inference

(2013) Brian K. Maples et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A robust clustering algorithm for identifying problematic samples in genome-wide association studies

(2011) Céline Bellenguez et al.   BIOINFORMATICS

Strong rules for discarding predictors in lasso-type problems

(2011) Robert Tibshirani et al.   JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

(2011) Gosia Trynka et al.   NATURE GENETICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Reduced Neutrophil Count in People of African Descent Is Due To a Regulatory Variant in the Duffy Antigen Receptor for Chemokines Gene

(2009) David Reich et al.   PLoS Genetics