Oligomeric and Fibrillar α-Synuclein Display Persistent Dynamics and Compressibility under Controlled Confinement

α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?

(2022) Lennart Brodin et al.   Frontiers in Molecular Biosciences

Coupling of ethanolamine ammonia-lyase protein and solvent dynamics characterized by the temperature-dependence of EPR spin probe mobility and dielectric permittivity

(2021) Alina Ionescu et al.   JOURNAL OF CHEMICAL PHYSICS

NMR unveils an N-terminal interaction interface on acetylated-α-synuclein monomers for recruitment to fibrils

(2021) Xue Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted

(2021) J. Mario Isas et al.   Nature Communications

Structural and Functional Insights into α-Synuclein Fibril Polymorphism

(2021) Surabhi Mehra et al.   Biomolecules

New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy

(2020) Ricardo Guerrero-Ferreira et al.   CURRENT OPINION IN NEUROBIOLOGY

α-Synuclein aggregation nucleates through liquid–liquid phase separation

(2020) Soumik Ray et al.   Nature Chemistry

Synapsins regulate α-synuclein functions

(2019) Merav Atias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling

(2019) Jichao Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiolipin Promotes Pore-Forming Activity of Alpha-Synuclein Oligomers in Mitochondrial Membranes

(2019) Stephanie Ghio et al.   ACS Chemical Neuroscience

Control of Solvent Dynamics around the B12-Dependent Ethanolamine Ammonia-Lyase Enzyme in Frozen Aqueous Solution by Using Dimethyl Sulfoxide Modulation of Mesodomain Volume

(2019) Benjamen Nforneh et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

(2019) Richard M. Meade et al.   Molecular Neurodegeneration

In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species

(2019) Martin Kiechle et al.   Cell Reports

A liquid phase of synapsin and lipid vesicles

(2018) Dragomir Milovanovic et al.   SCIENCE

Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy

(2018) Yaowang Li et al.   CELL RESEARCH

Dynamics of the Proline-Rich C-Terminus of Huntingtin Exon-1 Fibrils

(2018) Bethany G. Caulkins et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mesodomain and Protein-Associated Solvent Phases with Temperature-Tunable (200–265 K) Dynamics Surround Ethanolamine Ammonia-Lyase in Globally Polycrystalline Aqueous Solution Containing Dimethyl Sulfoxide

(2017) Benjamen Nforneh et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Spatially Heterogeneous Surface Water Diffusivity around Structured Protein Surfaces at Equilibrium

(2017) Ryan Barnes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Oligomer Hypothesis in α-Synucleinopathy

(2017) Kenjiro Ono   NEUROCHEMICAL RESEARCH

Liquid phase condensation in cell physiology and disease

(2017) Yongdae Shin et al.   SCIENCE

Synucleins Have Multiple Effects on Presynaptic Architecture

(2017) Karina J. Vargas et al.   Cell Reports

Stability of Protein-Specific Hydration Shell on Crowding

(2016) Kuo-Ying Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation

(2015) Serene W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Epigallocatechin Gallate Can Inhibit α-Synuclein Oligomer Toxicityin Vitro

(2014) Nikolai Lorenzen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse Metastable Structures Formed by Small Oligomers of α-Synuclein Probed by Force Spectroscopy

(2014) Krishna Neupane et al.   PLoS One

Spatial Dependence of Protein-Water Collective Hydrogen-Bond Dynamics

(2013) Matthias Heyden et al.   PHYSICAL REVIEW LETTERS

Quantitative cw Overhauser effect dynamic nuclear polarization for the analysis of local water dynamics

(2013) John M. Franck et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation

(2012) Igor F. Tsigelny et al.   FEBS Journal

Small-Angle Neutron Scattering Study of Protein Crowding in Liquid and Solid Phases: Lysozyme in Aqueous Solution, Frozen Solution, and Carbohydrate Powders

(2012) Joseph E. Curtis et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Protein and Water Dynamics in Bovine Serum Albumin–Water Mixtures over Wide Ranges of Composition

(2012) A. Panagopoulou et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Conformational Flexibility of Y145Stop Human Prion Protein Amyloid Fibrils Probed by Solid-State Nuclear Magnetic Resonance Spectroscopy

(2010) Jonathan J. Helmus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Freezing-Induced Phase Separation and Spatial Microheterogeneity in Protein Solutions

(2009) Jinping Dong et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A unified model of protein dynamics

(2009) H. Frauenfelder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electron spin–lattice relaxation of nitroxyl radicals in temperature ranges that span glassy solutions to low-viscosity liquids

(2008) Hideo Sato et al.   JOURNAL OF MAGNETIC RESONANCE

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level

(2008) Massimo Sandal et al.   PLOS BIOLOGY