An unprecedented base-promoted domino reaction of methyleneindolinones and N-tosyloxycarbamates for the construction of bispirooxindoles and spiroaziridine oxindoles

Diastereo- and Enantioselective Construction of 3,3′-Pyrrolidinyldispirooxindole Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions

(2015) Wei Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and Enantioselective Construction of a Bispirooxindole Scaffold Containing a Tetrahydro-β-carboline Moiety through an Organocatalytic Asymmetric Cascade Reaction

(2014) Wei Dai et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Organocatalytic Michael–Michael Cascade for the Enantioselective Construction of Spirocyclopentane Bioxindoles: Control of Four Contiguous Stereocenters

(2014) Wangsheng Sun et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Assembly Reactions: Synthesis of Spirooxindoles via Organocascade Strategies

(2014) Daojuan Cheng et al.   ACS Catalysis

Highly Efficient and Stereoselective Construction of Bispirooxindole Derivatives via a Three-Component 1,3-Dipolar Cycloaddition Reaction

(2014) Qin Xu et al.   ChemistryOpen

Vinylogous Organocatalytic Triple Cascade Reaction: Forging Six Stereocenters in Complex Spiro-Oxindolic Cyclohexanes

(2013) Indranil Chatterjee et al.   ADVANCED SYNTHESIS & CATALYSIS

3-Chlorooxindoles: Versatile Starting Materials for Asymmetric Organocatalytic Synthesis of Spirooxindoles

(2013) Artur Noole et al.   ADVANCED SYNTHESIS & CATALYSIS

Phosphine-Catalyzed Asymmetric [4+2] Annulation of Vinyl Ketones with Oxindole-Derived α,β-Unsaturated Imines: Enantioselective Syntheses of 2′,3′-Dihydro-1′H-spiro[indoline-3,4′-pyridin]-2-ones

(2013) Xiao-Nan Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Advances in Asymmetric Organocatalytic Construction of 3,3′-Spirocyclic Oxindoles

(2013) Liang Hong et al.   ADVANCED SYNTHESIS & CATALYSIS

Organocatalytic Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Azlactones and Methyleneindolinones

(2013) Wangsheng Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Control of Remote Stereochemistry in the Synthesis of Spirocyclic Oxindoles: Vinylogous Organocascade Catalysis

(2013) Xu Tian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlling the Molecular Topology of Vinylogous Iminium Ions by Logical Substrate Design: Highly Regio- and Stereoselective Aminocatalytic 1,6-Addition to Linear 2,4-Dienals

(2013) Mattia Silvi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Asymmetric Diels-Alder Reaction Catalyzed by Chiral Phosphate Magnesium Complexes: Highly Enantioselective Synthesis of Chiral Spirooxindoles

(2013) Guilong Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Tandem Approach to Spirocyclic Oxindoles Featuring Adjacent Spiro-Stereocenters

(2013) Yun-Lin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile one-pot synthesis of novel dispirooxindole-pyrrolidine derivatives and their antimicrobial and anticancer activity against A549 human lung adenocarcinoma cancer cell line

(2013) Y. Arun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An asymmetric approach toward chiral multicyclic spirooxindoles from isothiocyanato oxindoles and unsaturated pyrazolones by a chiral tertiary amine thiourea catalyst

(2013) Qiao Chen et al.   CHEMICAL COMMUNICATIONS

Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene

(2013) Xiaowei Dou et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric desymmetrization: efficient construction of spirocyclic oxindoles bearing a unique all-carbon quaternary stereogenic center via sulfa-Michael addition

(2013) Lu Yao et al.   CHEMICAL COMMUNICATIONS

An organocatalytic asymmetric sequential allylic alkylation–cyclization of Morita–Baylis–Hillman carbonates and 3-hydroxyoxindoles

(2013) Qi-Lin Wang et al.   CHEMICAL COMMUNICATIONS

Organocatalytic asymmetric remote aziridination of 2,4-dienals

(2013) Kim Søholm Halskov et al.   CHEMICAL COMMUNICATIONS

Enantioselective synthesis of diaryl aziridines using tetrahydrothiophene-based chiral sulfides as organocatalysts

(2013) Meng-Ting Huang et al.   CHEMICAL COMMUNICATIONS

3-Isothiocyanato Oxindoles Serving as Powerful and Versatile Precursors to Structurally Diverse Dispirocyclic Thiopyrrolidineoxindoles through a Cascade Michael/Cyclization Process with Amino-Thiocarbamate Catalysts

(2013) Wen-Yong Han et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Enantioselective Formal Hetero-Diels-Alder Reactions of Enones with Isatins to Give Spirooxindole Tetrahydropyranones

(2013) Hai-Lei Cui et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Organocatalytic Michael Addition/Cyclization Cascade Reaction of Ylideneoxindoles with Isothiocyanato Oxindoles: A Formal [3+2] Cycloaddition Approach to Optically Active Bispirooxindole Derivatives

(2013) Fen Tan et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Pyrrolo(spiro-[2.3′]-oxindole)-spiro-[4.3″]-oxindole via 1,3-Dipolar Cycloaddition of Azomethine Ylides with 3-Acetonylideneoxindole

(2013) Jun-An Xiao et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of Dispirocyclopentanebisoxindoles via Self-Domino Michael-Aldol Reactions of 3-Phenacylideneoxindoles

(2013) Jing Sun et al.   JOURNAL OF ORGANIC CHEMISTRY

Isotope Effects and Mechanism of the Asymmetric BOROX Brønsted Acid Catalyzed Aziridination Reaction

(2013) Mathew J. Vetticatt et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of polysubstituted pyrroles via [3 + 2]-annulation of aziridines and β-nitroalkenes under aerobic conditions

(2013) Shaoyin Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biomimetic Asymmetric 1,3-Dioplar Cycloaddition: Amino Acid Precursors in Biosynthesis Serve as Latent Azomethine Ylides

(2013) Chang Guo et al.   ORGANIC LETTERS

Asymmetric Catalysis for the Synthesis of Spirocyclic Compounds

(2013) Annaliese K. Franz et al.   ACS Catalysis

Organocatalytic stereocontrolled synthesis of 3,3′-pyrrolidinyl spirooxindoles by [3+2] annulation of isocyanoesters with methyleneindolinones

(2012) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

3-Bromooxindoles as nucleophiles in asymmetric organocatalytic Mannich reactions with N-Ts-imines

(2012) Jianhao Li et al.   CHEMICAL COMMUNICATIONS

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers

(2012) Wangsheng Sun et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantio- and Diastereoselective Generation of Two Quaternary Centers in Spirocyclopropanation of Oxindole Derivatives.

(2012) Artur Noole et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Efficient Enantioselective Construction of Bispirooxindoles Containing Three Stereocenters through an Organocatalytic Cascade Michael-Cyclization Reaction

(2012) Hao Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Scaffold-Inspired Enantioselective Synthesis of Biologically Important Spiro[pyrrolidin-3,2′-oxindoles] with Structural Diversity through Catalytic Isatin-Derived 1,3-Dipolar Cycloadditions

(2012) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric Michael Addition/Cyclization of Isothiocyanato Oxindoles: Highly Efficient and Versatile Approach for the Synthesis of 3,2′-Pyrrolidinyl Mono- and Bi-spirooxindole Frameworks

(2012) Yi-Ming Cao et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Efficient Synthesis of Novel Dispirooxindole Derivatives via One-Pot Three-Component 1,3-Dipolar Cycloaddition Reactions

(2012) Zhibin Huang et al.   MOLECULES

Strategies for the enantioselective synthesis of spirooxindoles

(2012) Nicolas R. Ball-Jones et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

HPLC-Assisted Automated Oligosaccharide Synthesis

(2012) N. Vijaya Ganesh et al.   ORGANIC LETTERS

Highly Efficient and Stereoselective Construction of Dispiro-[oxazolidine-2-thione]bisoxindoles and Dispiro[imidazolidine-2-thione]bisoxindoles

(2012) Yan-Yan Han et al.   ORGANIC LETTERS

Noncovalent Organocatalytic Synthesis of Enantioenriched Terminal Aziridines with a Quaternary Stereogenic Center

(2012) Claudia De Fusco et al.   ORGANIC LETTERS

Visible light induced intermolecular [2+2]-cycloaddition reactions of 3-ylideneoxindoles through energy transfer pathway

(2012) You-Quan Zou et al.   TETRAHEDRON

Highly enantioselective [4 + 2] annulations catalyzed by amino acid-based phosphines: Synthesis of functionalized cyclohexenes and 3-spirocyclohexene-2-oxindoles

(2012) Fangrui Zhong et al.   Chemical Science

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold-Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

(2011) Yiming Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A highly organocatalytic stereoselective double Michael reaction: efficient construction of optically enriched spirocyclic oxindoles

(2011) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Enantioselective methodologies for the synthesis of spiro compounds

(2011) Ramon Rios   CHEMICAL SOCIETY REVIEWS

Catalytic Asymmetric Aziridination of α,β-Unsaturated Aldehydes

(2011) Luca Deiana et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Catalysis of Diels–Alder Reactions with in Situ Generated Heterocyclicortho-Quinodimethanes

(2011) Yankai Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Aziridination of Cyclic Enones Using Chiral Diamine Catalysts and Its Application to the Total Synthesis of (−)-Agelastatin A

(2011) Yasuhiro Menjo et al.   ORGANIC LETTERS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Substituted spiro [2.3′] oxindolespiro [3.2″]-5,6-dimethoxy-indane-1″-one-pyrrolidine analogue as inhibitors of acetylcholinesterase

(2010) Mohamed Ashraf Ali et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Highly organocatalytic asymmetric Michael–ketone aldol–dehydration domino reaction: straightforward approach to construct six-membered spirocyclic oxindoles

(2010) Liang-Liang Wang et al.   CHEMICAL COMMUNICATIONS

Organocatalytic synthesis of spiro compounds via a cascade Michael–Michael-aldol reaction

(2010) Xavier Companyó et al.   CHEMICAL COMMUNICATIONS

Asymmetric Catalytic Aziridination of Cyclic Enones

(2010) Francesco De Vincentiis et al.   Chemistry-An Asian Journal

A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue

(2010) Xianxing Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Formaltrans-Dihydroxylation andtrans-Aminohydroxylation of α,β-Unsaturated Aldehydes via an Organocatalytic Reaction Cascade

(2010) Łukasz Albrecht et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Quadruple Aminocatalytic Domino Reactions to Fused Carbocycles Incorporating a Spirooxindole Motif

(2010) Kun Jiang et al.   ORGANIC LETTERS

Organocatalytic Asymmetric Formal [4 + 2] Cycloaddition for the Synthesis of Spiro[4-cyclohexanone-1,3′-oxindoline] Derivatives in High Optical Purity

(2010) Qiang Wei et al.   ORGANIC LETTERS

Highly Enantioselective Construction of Spiro[4H-pyran-3,3′-oxindoles] Through a Domino Knoevenagel/Michael/Cyclization Sequence Catalyzed by Cupreine

(2010) Wen-Bing Chen et al.   ORGANIC LETTERS

Synthesis of Functionalized Spiroaziridine-oxindoles from 3-Ylideneoxindoles: An Easy Route to 3-(Aminoalkyl)oxindoles

(2009) I. Ammetto et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

Organocatalytic Asymmetric Aziridination of Enones

(2008) Fabio Pesciaioli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic aziridination of electron-deficient olefins with an N-chloro-N-sodio carbamate and application of this novel method to asymmetric synthesis

(2008) Satoshi Minakata et al.   CHEMICAL COMMUNICATIONS

Regioselective synthesis of dispiro[1H-indene-2,3′-pyrrolidine-2′,3″-[3H]indole]-1,2″(1″H)-diones of potential anti-tumor properties

(2008) Adel S. Girgis   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY