Cathepsin K contributed to disturbed flow-induced atherosclerosis is dependent on integrin-actin cytoskeleton–NF–κB pathway

Fluid shear stress activates YAP to promote epithelial–mesenchymal transition in hepatocellular carcinoma

(2021) Hongchi Yu et al.   Molecular Oncology

Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow

(2021) Fengchan Li et al.   Cell Death Discovery

Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress

(2021) Xian Qin et al.   Bioactive Materials

The guidance receptor plexin D1 is a mechanosensor in endothelial cells

(2020) Vedanta Mehta et al.   NATURE

Disturbed Flow Induces Atherosclerosis by Annexin A2-Mediated Integrin Activation

(2020) Catherine Demos et al.   CIRCULATION RESEARCH

The molecular mechanism of mechanotransduction in vascular homeostasis and disease

(2020) Yoshito Yamashiro et al.   CLINICAL SCIENCE

Inappropriate cathepsin K secretion promotes its enzymatic activation driving heart and valve malformation

(2020) Po-Nien Lu et al.   JCI Insight

Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer

(2019) Rui Li et al.   CELL DEATH AND DIFFERENTIATION

Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes

(2019) Celine Souilhol et al.   Nature Reviews Cardiology

Inhibition of Ctsk modulates periodontitis with arthritis via downregulation of TLR9 and autophagy

(2019) Wei Wei et al.   CELL PROLIFERATION

Angiotensin II-Induced vascular remodeling and hypertension involves cathepsin L/V- MEK/ERK mediated mechanism

(2019) Yao Lu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Smooth Muscle Cells in Vascular Remodeling

(2019) Ning Shi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Novel Role of Id1 in Regulating Oscillatory Shear Stress-Mediated Lipid Uptake in Endothelial Cells

(2018) Kang Zhang et al.   ANNALS OF BIOMEDICAL ENGINEERING

Low-level shear stress promotes migration of liver cancer stem cells via the FAK-ERK1/2 signalling pathway

(2018) Jinghui Sun et al.   CANCER LETTERS

Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials

(2018) Cong-Lin Liu et al.   Nature Reviews Cardiology

Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis

(2018) Madhusudhan Budatha et al.   Journal of the American Heart Association

Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation

(2018) Julián Albarrán-Juárez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The immunology of atherosclerosis

(2017) Anton Gisterå et al.   Nature Reviews Nephrology

Vascular Semaphorin 7A Upregulation by Disturbed Flow Promotes Atherosclerosis Through Endothelial β1 Integrin

(2017) Shuhong Hu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice

(2016) Marjo M. P. C. Donners et al.   PLoS One

αvβ3 Integrins Mediate Flow-Induced NF-κB Activation, Proinflammatory Gene Expression, and Early Atherogenic Inflammation

(2015) Jie Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

 5 1 Integrin Signaling Mediates Oxidized Low-Density Lipoprotein-Induced Inflammation and Early Atherosclerosis

(2014) A. Yurdagul et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3

(2014) Daniel Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin K-mediated notch1 activation contributes to neovascularization in response to hypoxia

(2014) Haiying Jiang et al.   Nature Communications

The nuclear factor – kappa B pathway in atherosclerosis: A potential therapeutic target for atherothrombotic vascular disease

(2011) Burak Pamukcu et al.   THROMBOSIS RESEARCH

Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes

(2010) Natasha Barascuk et al.   BMC Cardiovascular Disorders

Histone Deacetylase 3 Is Critical in Endothelial Survival and Atherosclerosis Development in Response to Disturbed Flow

(2009) Anna Zampetaki et al.   CIRCULATION

Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K

(2009) Yu Sun et al.   CIRCULATION RESEARCH

Cathepsin K: boon or bale for atherosclerotic plaque stability?

(2008) O. Hofnagel et al.   CARDIOVASCULAR RESEARCH

Endothelial Cell-Specific NF-κB Inhibition Protects Mice from Atherosclerosis

(2008) Ralph Gareus et al.   Cell Metabolism