Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise
出版年份 2016 全文链接
标题
Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise
作者
关键词
-
出版物
FEBS Journal
Volume 283, Issue 19, Pages 3523-3533
出版商
Wiley
发表日期
2016-03-21
DOI
10.1111/febs.13714
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A phase 1 study evaluating the safety, pharmacokinetics, and efficacy of ABT-263 in subjects with refractory or relapsed lymphoid malignancies
- (2017) W. H. Wilson et al. JOURNAL OF CLINICAL ONCOLOGY
- PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors.
- (2017) S. Kopetz et al. JOURNAL OF CLINICAL ONCOLOGY
- Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
- (2016) Andrew W. Roberts et al. NEW ENGLAND JOURNAL OF MEDICINE
- Abstract 4728: Apoptotic priming is regulated by a developmental program and predisposes children to therapy-induced toxicity
- (2015) Kristopher A. Sarosiek et al. CANCER RESEARCH
- Abstract 2834: BH3 profiling predicts clinical response in a phase II clinical trial of ABT-199 (GDC-0199) in acute myeloid leukemia
- (2015) Leah Hogdal et al. CANCER RESEARCH
- Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family members
- (2015) Joseph T. Opferman FEBS Journal
- Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
- (2015) Steven M Chan et al. NATURE MEDICINE
- Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction
- (2015) A Y Robin et al. Cell Death & Disease
- Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
- (2015) J D Leverson et al. Cell Death & Disease
- MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies
- (2015) G S Choudhary et al. Cell Death & Disease
- Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers
- (2014) A. N. Hata et al. CANCER RESEARCH
- B Cell Lymphoma-2 (BCL-2) Homology Domain 3 (BH3) Mimetics Demonstrate Differential Activities Dependent upon the Functional Repertoire of Pro- and Anti-apoptotic BCL-2 Family Proteins
- (2014) Thibaud T. Renault et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis
- (2014) P. S. Winter et al. Science Signaling
- Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199
- (2014) T. N. Chonghaile et al. Cancer Discovery
- Requirement for antiapoptotic MCL-1 in the survival of BCR-ABL B-lineage acute lymphoblastic leukemia
- (2013) B. Koss et al. BLOOD
- Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer
- (2013) François Vaillant et al. CANCER CELL
- Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction
- (2013) X. Wang et al. GENES & DEVELOPMENT
- The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma
- (2013) C Touzeau et al. LEUKEMIA
- BH3 profiling in whole cells by fluorimeter or FACS
- (2013) Jeremy Ryan et al. METHODS
- BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response
- (2013) Kristopher A. Sarosiek et al. MOLECULAR CELL
- ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
- (2013) Andrew J Souers et al. NATURE MEDICINE
- BID-induced structural changes in BAK promote apoptosis
- (2013) Tudor Moldoveanu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mitochondria: gatekeepers of response to chemotherapy
- (2013) Kristopher A. Sarosiek et al. TRENDS IN CELL BIOLOGY
- Mitochondrial Regulation of Cell Death
- (2013) S. W. G. Tait et al. Cold Spring Harbor Perspectives in Biology
- Selective BCL-2 Inhibition by ABT-199 Causes On-Target Cell Death in Acute Myeloid Leukemia
- (2013) R. Pan et al. Cancer Discovery
- Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML
- (2012) Thanh-Trang Vo et al. CELL
- A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival
- (2012) Nicole A. Cohen et al. CHEMISTRY & BIOLOGY
- Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer
- (2012) C. M. Rudin et al. CLINICAL CANCER RESEARCH
- Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
- (2012) S. P. Glaser et al. GENES & DEVELOPMENT
- Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
- (2012) Anders Friberg et al. JOURNAL OF MEDICINAL CHEMISTRY
- Navitoclax (ABT-263) Reduces Bcl-xL-Mediated Chemoresistance in Ovarian Cancer Models
- (2012) M. Wong et al. MOLECULAR CANCER THERAPEUTICS
- Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
- (2012) Rhonda M. Perciavalle et al. NATURE CELL BIOLOGY
- An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737
- (2011) S. Al-harbi et al. BLOOD
- Distribution of Bim determines Mcl-1 dependence or codependence with Bcl-xL/Bcl-2 in Mcl-1-expressing myeloma cells
- (2011) A. A. Morales et al. BLOOD
- BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation
- (2011) M. Vogler et al. BLOOD
- Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors
- (2011) Leena Gandhi et al. JOURNAL OF CLINICAL ONCOLOGY
- Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease
- (2011) Andrew W. Roberts et al. JOURNAL OF CLINICAL ONCOLOGY
- Bid can mediate a pro-apoptotic response to etoposide and ionizing radiation without cleavage in its unstructured loop and in the absence of p53
- (2011) C Maas et al. ONCOGENE
- Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy
- (2011) T. N. Chonghaile et al. SCIENCE
- Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells
- (2010) B. Will et al. BLOOD
- Reversion of epigenetically mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma
- (2010) J. A. Richter-Larrea et al. BLOOD
- Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
- (2010) D. Yecies et al. BLOOD
- The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
- (2010) Michelle L Stewart et al. Nature Chemical Biology
- Mitochondria and cell death: outer membrane permeabilization and beyond
- (2010) Stephen W. G. Tait et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis
- (2010) A Bender et al. ONCOGENE
- Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines
- (2010) H Zhang et al. ONCOGENE
- Targeting the PI3K signaling pathway in cancer
- (2009) Kwok-Kin Wong et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis
- (2009) Hyungjin Kim et al. MOLECULAR CELL
- Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia
- (2008) M. Vogler et al. BLOOD
- Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax
- (2008) Jonathan F. Lovell et al. CELL
- Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis
- (2008) S. P. Garrison et al. MOLECULAR AND CELLULAR BIOLOGY
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