Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin

CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity

(2015) C. Yang et al.   CANCER RESEARCH

Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL

(2015) M. C. Stubbs et al.   CLINICAL CANCER RESEARCH

The potential of clofarabine in MLL -rearranged infant acute lymphoblastic leukaemia

(2015) Dominique J.P.M. Stumpel et al.   EUROPEAN JOURNAL OF CANCER

Dinaciclib is a novel cyclin-dependent kinase inhibitor with significant clinical activity in relapsed and refractory chronic lymphocytic leukemia

(2015) J Flynn et al.   LEUKEMIA

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia

(2015) Ajay Abraham et al.   PHARMACOGENOMICS

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma

(2014) S. K. Kumar et al.   BLOOD

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia

(2014) B. Xu et al.   BLOOD

Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia

(2014) Jeffery M. Klco et al.   CANCER CELL

Cancer Cell Lines for Drug Discovery and Development

(2014) J. L. Wilding et al.   CANCER RESEARCH

Bortezomib for the treatment of non-Hodgkin’s lymphoma

(2014) Prithviraj Bose et al.   EXPERT OPINION ON PHARMACOTHERAPY

Epigenetics in the hematologic malignancies

(2014) C. Y. Fong et al.   HAEMATOLOGICA

Update on treatment of light chain amyloidosis

(2014) S. Mahmood et al.   HAEMATOLOGICA

Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

(2014) Panagiotis Ntziachristos et al.   NATURE

A comprehensive transcriptional portrait of human cancer cell lines

(2014) Christiaan Klijn et al.   NATURE BIOTECHNOLOGY

Normalization of RNA-seq data using factor analysis of control genes or samples

(2014) Davide Risso et al.   NATURE BIOTECHNOLOGY

Targeting the wee1 kinase for treatment of pediatric Down syndrome acute myeloid leukemia

(2014) J. Timothy Caldwell et al.   PEDIATRIC BLOOD & CANCER

Intensified chemotherapy without SCT in infant ALL: Results from COG P9407 (Cohort 3)

(2014) ZoAnn E. Dreyer et al.   PEDIATRIC BLOOD & CANCER

Patient-derived models of acquired resistance can identify effective drug combinations for cancer

(2014) Adam S. Crystal et al.   SCIENCE

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

(2014) M. Yu et al.   SCIENCE

The evolution of clinical trials for infant acute lymphoblastic leukemia

(2014) R S Kotecha et al.   Blood Cancer Journal

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts

(2013) Richard D.W. Kelly et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

New cast for a new era: preclinical cancer drug development revisited

(2013) Grit S. Herter-Sprie et al.   JOURNAL OF CLINICAL INVESTIGATION

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer

(2012) S. Julien et al.   CLINICAL CANCER RESEARCH

The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression

(2012) T. Derrien et al.   GENOME RESEARCH

Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group

(2012) Stephen P. Hunger et al.   JOURNAL OF CLINICAL ONCOLOGY

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Modeling and predicting clinical efficacy for drugs targeting the tumor milieu

(2012) Mallika Singh et al.   NATURE BIOTECHNOLOGY

FusionFinder: A Software Tool to Identify Expressed Gene Fusion Candidates from RNA-Seq Data

(2012) Richard W. Francis et al.   PLoS One

Measuring reproducibility of high-throughput experiments

(2011) Qunhua Li et al.   Annals of Applied Statistics

Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma

(2011) R. L. Piekarz et al.   BLOOD

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia

(2011) D J P M Stumpel et al.   LEUKEMIA

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

(2011) Mark A. Dawson et al.   NATURE

Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells

(2010) Jyoti Panicker et al.   CELL CYCLE

Mechanisms of Synergistic Antileukemic Interactions between Valproic Acid and Cytarabine in Pediatric Acute Myeloid Leukemia

(2010) C. Xie et al.   CLINICAL CANCER RESEARCH

Analysis of the Role of Hematopoietic Stem-Cell Transplantation in Infants With Acute Lymphoblastic Leukemia in First Remission andMLLGene Rearrangements: A Report From the Children's Oncology Group

(2010) ZoAnn E. Dreyer et al.   JOURNAL OF CLINICAL ONCOLOGY

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

(2010) James E. Bradner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling network analysis of ubiquitin-mediated proteins suggests correlations between the 26S proteasome and tumor progression

(2009) Cong Fu et al.   Molecular BioSystems

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

A xenograft model of infant leukaemia reveals a complex MLL translocation

(2008) Michelle J. Henderson et al.   BRITISH JOURNAL OF HAEMATOLOGY

Gemcitabine and Cytosine Arabinoside Cytotoxicity: Association with Lymphoblastoid Cell Expression

(2008) L. Li et al.   CANCER RESEARCH