标题
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
作者
关键词
-
出版物
NATURE BIOTECHNOLOGY
Volume 30, Issue 7, Pages 648-657
出版商
Springer Nature
发表日期
2012-07-10
DOI
10.1038/nbt.2286
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway
- (2012) Vesselina G. Cooke et al. CANCER CELL
- A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
- (2012) Zhao Chen et al. NATURE
- Raise standards for preclinical cancer research
- (2012) C. Glenn Begley et al. NATURE
- Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors
- (2012) Barbara Sennino et al. Cancer Discovery
- Unraveling the Genetics of Cancer: Genome Sequencing and Beyond
- (2011) Kit Man Wong et al. Annual Review of Genomics and Human Genetics
- Lung Cancer Signatures in Plasma Based on Proteome Profiling of Mouse Tumor Models
- (2011) Ayumu Taguchi et al. CANCER CELL
- Chemotherapeutic Resistance: Surviving Stressful Situations
- (2011) L. A. Gilbert et al. CANCER RESEARCH
- A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference
- (2011) Prem K. Premsrirut et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Adaptive Clinical Trial Designs for Simultaneous Testing of Matched Diagnostics and Therapeutics
- (2011) H. I. Scher et al. CLINICAL CANCER RESEARCH
- Brivanib, a Dual FGF/VEGF Inhibitor, Is Active Both First and Second Line against Mouse Pancreatic Neuroendocrine Tumors Developing Adaptive/Evasive Resistance to VEGF Inhibition
- (2011) Elizabeth Allen et al. CLINICAL CANCER RESEARCH
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- (2011) H. Wong et al. CLINICAL CANCER RESEARCH
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- (2011) David Bruce et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
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- (2011) Yihai Cao INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
- Randomized Phase II Trials: A Long-term Investment With Promising Returns
- (2011) M. R. Sharma et al. JNCI-Journal of the National Cancer Institute
- Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study
- (2011) Hedy L Kindler et al. LANCET ONCOLOGY
- Translational research: The American way
- (2011) Amy Maxmen NATURE
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- (2011) Ira Mellman et al. NATURE
- Emerging molecular biomarkers—blood-based strategies to detect and monitor cancer
- (2011) Samir M. Hanash et al. Nature Reviews Clinical Oncology
- Antiangiogenic therapy: impact on invasion, disease progression and metastasis
- (2011) John M. L. Ebos et al. Nature Reviews Clinical Oncology
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- (2011) W. Joost Lesterhuis et al. NATURE REVIEWS DRUG DISCOVERY
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- (2011) Jesse S. Boehm et al. NATURE REVIEWS GENETICS
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- (2011) Robert A. Burger et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Phase 3 Trial of Bevacizumab in Ovarian Cancer
- (2011) Timothy J. Perren et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sunitinib Malate for the Treatment of Pancreatic Neuroendocrine Tumors
- (2011) Eric Raymond et al. NEW ENGLAND JOURNAL OF MEDICINE
- Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma
- (2011) P. Olson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2011) R. L. Schilsky Science Translational Medicine
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- (2011) L. V. Sequist et al. Science Translational Medicine
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- (2010) John P. Gibbs AAPS Journal
- Antiangiogenic agents and targets: A perspective
- (2010) Beverly A. Teicher BIOCHEMICAL PHARMACOLOGY
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- (2010) P Workman et al. BRITISH JOURNAL OF CANCER
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- (2010) David Miles et al. JOURNAL OF CLINICAL ONCOLOGY
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- (2010) Axel Hoos et al. SEMINARS IN ONCOLOGY
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- (2010) Margaret K. Callahan et al. SEMINARS IN ONCOLOGY
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- (2010) T. Maziasz et al. TOXICOLOGIC PATHOLOGY
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- (2009) Yongping Crawford et al. CANCER CELL
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- (2009) John M.L. Ebos et al. CANCER CELL
- Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis
- (2009) Marta Pàez-Ribes et al. CANCER CELL
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- (2009) L. Gandhi et al. Cancer Prevention Research
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- (2009) M. Pajic et al. CANCER RESEARCH
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- (2009) J. D. Wolchok et al. CLINICAL CANCER RESEARCH
- Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma
- (2009) K. Politi et al. Disease Models & Mechanisms
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- (2009) Michalis V Karamouzis et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Cancer associated fibroblasts (CAFs) in tumor microenvironment
- (2009) Fei Xing Frontiers in Bioscience-Landmark
- Mouse models of human AML accurately predict chemotherapy response
- (2009) J. Zuber et al. GENES & DEVELOPMENT
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- (2009) Roopali Roy et al. JOURNAL OF CLINICAL ONCOLOGY
- Precompetitive preclinical ADME/Tox data: set it free on the web to facilitate computational model building and assist drug development
- (2009) Sean Ekins et al. LAB ON A CHIP
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- (2009) Yinghui Zhou et al. NATURE BIOTECHNOLOGY
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- (2009) Jia Jia et al. NATURE REVIEWS DRUG DISCOVERY
- Cell-type-specific isolation of ribosome-associated mRNA from complex tissues
- (2009) E. Sanz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
- (2009) K. P. Olive et al. SCIENCE
- Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies
- (2009) Yongping Crawford et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types
- (2008) Joseph P. Doyle et al. CELL
- A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types
- (2008) Myriam Heiman et al. CELL
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- (2008) S ROTTENBERG et al. DRUG RESISTANCE UPDATES
- Cancer and Immune Response: Old and New Evidence for Future Challenges
- (2008) L. de la Cruz-Merino et al. ONCOLOGIST
- In Vivo/Ex Vivo and In Situ Assays Used in Cancer Research: A Brief Review
- (2008) Beverly A. Teicher TOXICOLOGIC PATHOLOGY
- Development trends for new cancer therapeutics and vaccines
- (2007) J REICHERT DRUG DISCOVERY TODAY
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