Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance

Predominant Role of mTOR Signaling in Skin Diseases with Therapeutic Potential

(2022) Fani Karagianni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Contemporary Applications of thermogelling PEO-PPO-PEO triblock copolymers

(2022) Kwadwo Mfoafo et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Advances in the pathogenesis of psoriasis: from keratinocyte perspective

(2022) Xue Zhou et al.   Cell Death & Disease

Update on the etiopathogenesis of psoriasis (Review)

(2022) Daciana Branisteanu et al.   Experimental and Therapeutic Medicine

Potential and Therapeutic Roles of Diosmin in Human Diseases

(2022) Etimad Huwait et al.   Biomedicines

Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide

(2022) Marcin Feldo et al.   MOLECULES

A Review of Polymeric Micelles and Their Applications

(2022) Suguna Perumal et al.   Polymers

Biological and intracellular fates of drug nanocrystals through different delivery routes: Recent development enabled by bioimaging and PK modeling

(2022) Yongjiu Lv et al.   ADVANCED DRUG DELIVERY REVIEWS

Different cellulosic polymers for synthesizing silver nanoparticles with antioxidant and antibacterial activities

(2021) Ahmed A. H. Abdellatif et al.   Scientific Reports

Application of imiquimod-induced murine psoriasis model in evaluating interleukin-17A antagonist

(2021) Qingran Li et al.   BMC IMMUNOLOGY

Studying the Effects of Temperature on the Nucleation and Growth of Nanoparticles by Liquid-Cell Transmission Electron Microscopy

(2021) Abdelali Khelfa et al.   Jove-Journal of Visualized Experiments

Gamma Delta T Cells and Their Pathogenic Role in Psoriasis

(2021) Cong Qi et al.   Frontiers in Immunology

Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using Poloxamer 407-Based Solid Dispersion via the Anti-Solvent Method

(2021) Gang Jin et al.   Pharmaceutics

Recent Updates on the Involvement of PI3K/AKT/mTOR Molecular Cascade in the Pathogenesis of Hyperproliferative Skin Disorders

(2021) Laura Mercurio et al.   Frontiers in Medicine

Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review

(2021) Samar H. Gerges et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Diosmin in combination with naringenin enhances apoptosis in colon cancer cells

(2021) Bushra Zeya et al.   ONCOLOGY REPORTS

Nanoparticles Based on Hydrophobic Polysaccharide Derivatives—Formation Principles, Characterization Techniques, and Biomedical Applications

(2020) Martin Gericke et al.   MACROMOLECULAR BIOSCIENCE

Advanced Characterization of Imiquimod-Induced Psoriasis-Like Mouse Model

(2020) Mehwish Jabeen et al.   Pharmaceutics

Diosmin restores the skin barrier by targeting the aryl hydrocarbon receptor in atopic dermatitis

(2020) Jangho Lee et al.   PHYTOMEDICINE

Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity

(2019) Nahla Yassin Sahlol et al.   PLoS One

IL-21 Induces an Imbalance of Th17/Treg Cells in Moderate-to-Severe Plaque Psoriasis Patients

(2019) Yuling Shi et al.   Frontiers in Immunology

Foxp3+T reg cells control psoriasiform inflammation by restraining an IFN-I–driven CD8+T cell response

(2018) Krista Stockenhuber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Keratinocyte expression of A20/TNFAIP3 controls skin inflammation associated with atopic dermatitis and psoriasis

(2018) Michael Devos et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability

(2018) Maria Gigliobianco et al.   Pharmaceutics

Diosmin Nanocrystals Loaded Wafers for Treatment Of Diabetic Ulcer: In-Vitro And In-Vivo Evaluation

(2018) Nouran M. Atia et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mouse model of imiquimod-induced psoriatic itch

(2016) Kent Sakai et al.   PAIN

Diosmin downregulates the expression of T cell receptors, pro-inflammatory cytokines and NF-κB activation against LPS-induced acute lung injury in mice

(2015) Faisal Imam et al.   PHARMACOLOGICAL RESEARCH

NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis

(2015) Sha Yan et al.   Nature Communications

Resveratrol Ameliorates Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice

(2015) Thomas Nordstrøm Kjær et al.   PLoS One

Immunology of Psoriasis

(2014) Michelle A. Lowes et al.   Annual Review of Immunology

TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis

(2013) Barry Flutter et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting Interleukin-22 in Psoriasis

(2013) Ji-Qing Hao   INFLAMMATION

A Toll-Like Receptor 7, 8, and 9 Antagonist Inhibits Th1 and Th17 Responses and Inflammasome Activation in a Model of IL-23-Induced Psoriasis

(2013) Weiwen Jiang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Roles of TLR7 in Activation of NF-κB Signaling of Keratinocytes by Imiquimod

(2013) Zheng Jun Li et al.   PLoS One

Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model

(2013) Mir Tahir et al.   TOXICOLOGY LETTERS

Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways

(2012) Mingming Hu et al.   JOURNAL OF APPLIED TOXICOLOGY

MicroRNA-31 Is Overexpressed in Psoriasis and Modulates Inflammatory Cytokine and Chemokine Production in Keratinocytes via Targeting Serine/Threonine Kinase 40

(2012) N. Xu et al.   JOURNAL OF IMMUNOLOGY

Foxp3+ Regulatory T Cells of Psoriasis Patients Easily Differentiate into IL-17A-Producing Cells and Are Found in Lesional Skin

(2011) H. Jorn Bovenschen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Increase in FOXP3+ Regulatory T Cells in GVHD Skin Biopsies Is Associated with Lower Disease Severity and Treatment Response

(2009) Cristina Fondi et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY