Role of tumor microenvironment in cancer progression and therapeutic strategy

Kinetic modeling: A tool for temperature shift and feeding optimization in cell culture process development

(2022) Zheyu Wang et al.   PROTEIN EXPRESSION AND PURIFICATION

Impact of postal correspondence letters on participation in cancer screening: a rapid review

(2021) Mafo Yakubu et al.   PREVENTIVE MEDICINE

Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice

(2021) Se-Hoon Lee et al.   Nature Microbiology

Immune Checkpoint Inhibitors for the Treatment of Bladder Cancer

(2021) Antonio Lopez-Beltran et al.   Cancers

Ablative Radiotherapy Reprograms the Tumor Microenvironment of a Pancreatic Tumor in Favoring the Immune Checkpoint Blockade Therapy

(2021) Yu-Hung Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients

(2021) Diwakar Davar et al.   SCIENCE

The Role of Tumor Microenvironment in Cancer Metastasis: Molecular Mechanisms and Therapeutic Opportunities

(2021) Christiana M. Neophytou et al.   Cancers

The role of PD-L1 in the immune dysfunction that mediates hypoxia-induced multiple organ injury

(2021) Yang Sun et al.   Cell Communication and Signaling

Clinical and therapeutic relevance of cancer-associated fibroblasts

(2021) Yang Chen et al.   Nature Reviews Clinical Oncology

Metabolic modulation of tumours with engineered bacteria for immunotherapy

(2021) Fernando P. Canale et al.   NATURE

The foundations of immune checkpoint blockade and the ipilimumab approval decennial

(2021) Alan J. Korman et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors

(2021) Navid Ghahri-Saremi et al.   Frontiers in Immunology

Gut Microbiota for Esophageal Cancer: Role in Carcinogenesis and Clinical Implications

(2021) Jianfeng Zhou et al.   Frontiers in Oncology

Emerging targets for anticancer vaccination: PD-1

(2021) J. Tobias et al.   ESMO Open

NK cells for cancer immunotherapy

(2020) Noriko Shimasaki et al.   NATURE REVIEWS DRUG DISCOVERY

Modeling the Tumor Microenvironment and Pathogenic Signaling in Bone Sarcoma

(2020) Eric R. Molina et al.   TISSUE ENGINEERING PART B-REVIEWS

Microenvironment-Dependent Gradient of CTL Exhaustion in the AE17sOVA Murine Mesothelioma Tumor Model

(2020) Jennifer L. Hope et al.   Frontiers in Immunology

Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics

(2020) Vinayaka Kotraiah et al.   Frontiers in Immunology

SnapShot: Cancer-Associated Fibroblasts

(2020) Danielle Park et al.   CELL

Immune checkpoint signaling and cancer immunotherapy

(2020) Xing He et al.   CELL RESEARCH

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

(2020) Maria Paula Roberti et al.   NATURE MEDICINE

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

(2020) Deborah Nejman et al.   SCIENCE

CCN-Based Therapeutic Peptides Modify Pancreatic Ductal Adenocarcinoma Microenvironment and Decrease Tumor Growth in Combination with Chemotherapy

(2020) Andrea Resovi et al.   Cells

Variation of PD-L1 expression in locally advanced cervical cancer following neoadjuvant chemotherapy

(2020) Yun Liang et al.   Diagnostic Pathology

Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

(2020) Wenyu Wang et al.   Journal of Hematology & Oncology

Re-education of the Tumor Microenvironment With Targeted Therapies and Immunotherapies

(2020) Shin Foong Ngiow et al.   Frontiers in Immunology

PD-1 Immune Checkpoint Blockade Promotes Therapeutic Cancer Vaccine to Eradicate Lung Cancer

(2020) Pournima Kadam et al.   Vaccines

Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy

(2020) Leilei Ai et al.   Drug Design Development and Therapy

Dostarlimab in the treatment of recurrent or primary advanced endometrial cancer

(2020) Lawrence Kasherman et al.   Future Oncology

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

(2020) Erez N. Baruch et al.   SCIENCE

Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy

(2020) Richard Lee Barrett et al.   eLife

Cancer Vaccines: Toward the Next Breakthrough in Cancer Immunotherapy

(2020) Yuka Igarashi et al.   Journal of Immunology Research

The Intestinal Microbiota and Colorectal Cancer

(2020) Yiwen Cheng et al.   Frontiers in Immunology

Tumor Microenvironment Uses a Reversible Reprogramming of Mesenchymal Stromal Cells to Mediate Pro-tumorigenic Effects

(2020) Armel H. Nwabo Kamdje et al.   Frontiers in Cell and Developmental Biology

Myeloid-Derived Suppressor Cells: Facilitators of Cancer and Obesity-Induced Cancer

(2020) Suzanne Ostrand-Rosenberg   Annual Review of Cancer Biology-Series

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

(2019) Xianjie Jiang et al.   Molecular Cancer

Mechanisms of resistance to CAR T cell therapy

(2019) Nirali N. Shah et al.   Nature Reviews Clinical Oncology

The microbiome, cancer, and cancer therapy

(2019) Beth A. Helmink et al.   NATURE MEDICINE

Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non–small cell lung cancer

(2019) Bo Gong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Tumor Microenvironment for Cancer Therapy

(2019) Catarina Roma-Rodrigues et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes in cancer development, metastasis, and immunity

(2019) Lin Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Immune suppression by PD-L2 against spontaneous and treatment-related antitumor immunity

(2019) Hiroyoshi Nishikawa et al.   CLINICAL CANCER RESEARCH

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

(2019) Ladan Mashouri et al.   Molecular Cancer

Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance

(2019) Micol Eleonora Fiori et al.   Molecular Cancer

Development of the Inhibitors that Target the PD-1/PD-L1 Interaction—A Brief Look at Progress on Small Molecules, Peptides and Macrocycles

(2019) Guzik et al.   MOLECULES

Profile of pembrolizumab in the treatment of patients with unresectable or metastatic urothelial carcinoma

(2019) Junichi Inokuchi et al.   Cancer Management and Research

The Tumor Microenvironment Innately Modulates Cancer Progression

(2019) Dominique C. Hinshaw et al.   CANCER RESEARCH

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion

(2019) Li-Chuan Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Combination of CTLA-4 and PD-1 blockers for treatment of cancer

(2019) Anand Rotte   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Microenvironmental Regulation of Tumor Progression and Therapeutic Response in Brain Metastasis

(2019) Michael Schulz et al.   Frontiers in Immunology

Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with hepatocellular carcinoma

(2019) Yi Zheng et al.   Journal for ImmunoTherapy of Cancer

Mechanically tunable coaxial electrospun models of YAP/TAZ mechanoresponse and IGF-1R activation in osteosarcoma

(2019) Eric R. Molina et al.   Acta Biomaterialia

Immunity, Hypoxia and Metabolism - the ménage à trois of cancer: implications for immunotherapy

(2019) Carla Riera-Domingo et al.   PHYSIOLOGICAL REVIEWS

Cemiplimab-rwlc as first and only treatment for advanced cutaneous squamous cell carcinoma

(2019) Saqib R. Ahmed et al.   Expert Review of Clinical Pharmacology

Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges

(2019) Muhammad Zaeem Noman et al.   Cells

Metabolic kinetic modeling provides insight into complex biological questions, but hurdles remain

(2019) Jonathan Strutz et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metabolic crosstalk in the breast cancer microenvironment

(2019) Ana S. Dias et al.   EUROPEAN JOURNAL OF CANCER

Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment

(2019) Li Yang et al.   Journal of Hematology & Oncology

The role of exosomal PD-L1 in tumor progression and immunotherapy

(2019) Feiting Xie et al.   Molecular Cancer

The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals

(2019) Elliot A. Philips et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nivolumab in the treatment of microsatellite instability high metastatic colorectal cancer

(2018) Amir Mehrvarz Sarshekeh et al.   Future Oncology

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis

(2018) Neibla Priego et al.   NATURE MEDICINE

Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges

(2018) Dai Fukumura et al.   Nature Reviews Clinical Oncology

Tracking the fate of adoptively transferred myeloid-derived suppressor cells in the primary breast tumor microenvironment

(2018) Jaclyn Sceneay et al.   PLoS One

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Houdini Tumor: Case Report and Literature Review of Pregnancy-Associated Meningioma

(2018) Vikram Chakravarthy et al.   World Neurosurgery

Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management

(2018) Jennifer N. Brudno et al.   BLOOD REVIEWS

Effects of tumor metabolic microenvironment on regulatory T cells

(2018) Yi-an Wang et al.   Molecular Cancer

Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

(2018) Yinghong Wang et al.   NATURE MEDICINE

Product review: avelumab, an anti-PD-L1 antibody

(2018) Julie M. Collins et al.   Human Vaccines & Immunotherapeutics

MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells

(2017) Daniel Yee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New development in CAR-T cell therapy

(2017) Zhenguang Wang et al.   Journal of Hematology & Oncology

Combined Radiotherapy and Anti–PD-L1 Antibody Synergistically Enhances Antitumor Effect in Non–Small Cell Lung Cancer

(2017) Xiaomei Gong et al.   Journal of Thoracic Oncology

Prognostic significance of metabolic enzyme pyruvate kinase M2 in breast cancer

(2017) Yiming Yang et al.   MEDICINE

Implications of the tumor immune microenvironment for staging and therapeutics

(2017) Janis M Taube et al.   MODERN PATHOLOGY

Intra-tumor heterogeneity from a cancer stem cell perspective

(2017) Pramudita R. Prasetyanti et al.   Molecular Cancer

Radiotherapy and immunotherapy: a beneficial liaison?

(2017) Ralph R. Weichselbaum et al.   Nature Reviews Clinical Oncology

Metabolic strategies of melanoma cells: Mechanisms, interactions with the tumor microenvironment, and therapeutic implications

(2017) Grant M. Fischer et al.   Pigment Cell & Melanoma Research

Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2

(2017) Krzysztof M. Zak et al.   STRUCTURE

Metabolic Interactions in the Tumor Microenvironment

(2017) Costas A. Lyssiotis et al.   TRENDS IN CELL BIOLOGY

Current Multistage Drug Delivery Systems Based on the Tumor Microenvironment

(2017) Binlong Chen et al.   Theranostics

Advancing chimeric antigen receptor T cell therapy with CRISPR/Cas9

(2017) Jiangtao Ren et al.   Protein & Cell

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

(2017) Irene Scarfò et al.   Journal for ImmunoTherapy of Cancer

Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy

(2017) Seema Gupta et al.   Frontiers in Oncology

Pathomimetic cancer avatars for live-cell imaging of protease activity

(2016) Kyungmin Ji et al.   BIOCHIMIE

Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade

(2016) Haidong Tang et al.   CANCER CELL

Tumor microenvironment and cancer therapy resistance

(2016) Yu Sun   CANCER LETTERS

Atezolizumab: A PD-L1–Blocking Antibody for Bladder Cancer

(2016) Brant A. Inman et al.   CLINICAL CANCER RESEARCH

The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

(2016) Nicole E. Scharping et al.   IMMUNITY

Tandem CAR T cells targeting HER2 and IL13Rα2 mitigate tumor antigen escape

(2016) Meenakshi Hegde et al.   JOURNAL OF CLINICAL INVESTIGATION

IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma

(2016) Salah-Eddine Lamhamedi-Cherradi et al.   JNCI-Journal of the National Cancer Institute

PKM2 and cancer: The function of PKM2 beyond glycolysis

(2016) GAOCHAO DONG et al.   Oncology Letters

IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma

(2016) Salah-Eddine Lamhamedi-Cherradi et al.   JNCI-Journal of the National Cancer Institute

Chemoradiation Increases PD-L1 Expression in Certain Melanoma and Glioblastoma Cells

(2016) Anja Derer et al.   Frontiers in Immunology

The effect of environmental chemicals on the tumor microenvironment

(2015) Stephanie C. Casey et al.   CARCINOGENESIS

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

Increased complexity in carcinomas: Analyzing and modeling the interaction of human cancer cells with their microenvironment

(2015) Mira Stadler et al.   SEMINARS IN CANCER BIOLOGY

Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

PD-1 induction through TCR activation is partially regulated by endogenous TGF-β

(2014) Raja Rekik et al.   Cellular & Molecular Immunology

Multifactorial T-cell Hypofunction That Is Reversible Can Limit the Efficacy of Chimeric Antigen Receptor-Transduced Human T cells in Solid Tumors

(2014) E. K. Moon et al.   CLINICAL CANCER RESEARCH

Consideration of GREB1 as a potential therapeutic target for hormone-responsive or endocrine-resistant cancers

(2014) Kendra M Hodgkinson et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mast Cell Function

(2014) Elaine Zayas Marcelino da Silva et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

MicroRNA-513 Regulates B7-H1 Translation and Is Involved in IFN- -Induced B7-H1 Expression in Cholangiocytes

(2014) A.-Y. Gong et al.   JOURNAL OF IMMUNOLOGY

Curcumin Suppresses Crosstalk between Colon Cancer Stem Cells and Stromal Fibroblasts in the Tumor Microenvironment: Potential Role of EMT

(2014) Constanze Buhrmann et al.   PLoS One

Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression

(2014) J. L. Heinecke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Look back in anger – what clinical studies tell us about preclinical work

(2014) Thomas Hartung   ALTEX-Alternatives to Animal Experimentation

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

(2013) J. Duraiswamy et al.   CANCER RESEARCH

Three-dimensional spatial configuration of tumour cells confers resistance to chemotherapy independent of drug delivery

(2013) Pamela H. S. Tan et al.   Journal of Tissue Engineering and Regenerative Medicine

Combinational Targeting Offsets Antigen Escape and Enhances Effector Functions of Adoptively Transferred T Cells in Glioblastoma

(2013) Meenakshi Hegde et al.   MOLECULAR THERAPY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

(2013) Zakaria Grada et al.   Molecular Therapy-Nucleic Acids

Natural and Induced T Regulatory Cells in Cancer

(2013) Dennis O. Adeegbe et al.   Frontiers in Immunology

The Insulin-Like Growth Factor System in Bone

(2012) Masanobu Kawai et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

(2012) Akio Ohta et al.   Frontiers in Immunology

Radiation-induced cell death mechanisms

(2010) David Eriksson et al.   TUMOR BIOLOGY

Development of IGF-IR inhibitors in pediatric sarcomas

(2009) E. Anders Kolb et al.   Current Oncology Reports

TGFβ in Cancer

(2008) Joan Massagué   CELL