SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice
出版年份 2023 全文链接
标题
SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice
作者
关键词
-
出版物
Cell Reports
Volume 42, Issue 3, Pages 112189
出版商
Elsevier BV
发表日期
2023-02-17
DOI
10.1016/j.celrep.2023.112189
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Pathological sequelae of long-haul COVID
- (2022) Saurabh Mehandru et al. NATURE IMMUNOLOGY
- Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID ‐19
- (2022) Alexandra C. Apple et al. Annals of Clinical and Translational Neurology
- The synapse as a treatment avenue for Alzheimer’s Disease
- (2022) Lin Peng et al. MOLECULAR PSYCHIATRY
- SARS-CoV-2 is associated with changes in brain structure in UK Biobank
- (2022) Gwenaëlle Douaud et al. NATURE
- SARS-CoV-2 pathogenesis
- (2022) Mart M. Lamers et al. NATURE REVIEWS MICROBIOLOGY
- The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2
- (2022) Lisa Bauer et al. TRENDS IN NEUROSCIENCES
- Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates
- (2022) Ibolya Rutkai et al. Nature Communications
- SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death
- (2022) Junyoung Oh et al. Scientific Reports
- From a recombinant key antigen to an accurate, affordable serological test: Lessons learnt from COVID-19 for future pandemics
- (2022) Renata G.F. Alvim et al. BIOCHEMICAL ENGINEERING JOURNAL
- Symptoms and risk factors for long COVID in non-hospitalized adults
- (2022) Anuradhaa Subramanian et al. NATURE MEDICINE
- SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations post recovery
- (2022) Justin J. Frere et al. Science Translational Medicine
- SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice
- (2022) Kenneth H. Dinnon et al. Science Translational Medicine
- Immunoinformatic approach for the construction of multi-epitopes vaccine against omicron COVID-19 variant
- (2022) Kanwal Khan et al. VIROLOGY
- Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae
- (2022) Zoe Swank et al. CLINICAL INFECTIOUS DISEASES
- SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
- (2022) Eduardo A. Albornoz et al. MOLECULAR PSYCHIATRY
- Long-term neurologic outcomes of COVID-19
- (2022) Evan Xu et al. NATURE MEDICINE
- The neurobiology of long COVID
- (2022) Michelle Monje et al. NEURON
- Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study
- (2022) Manina M. Etter et al. Nature Communications
- The roles of microglia in viral encephalitis: from sensome to therapeutic targeting
- (2021) Chintan Chhatbar et al. Cellular & Molecular Immunology
- SARS-CoV-2 encephalitis is a cytokine release syndrome: evidences from cerebrospinal fluid analyses
- (2021) Andrea Pilotto et al. CLINICAL INFECTIOUS DISEASES
- 18F-FDG brain PET hypometabolism in patients with long COVID
- (2021) E. Guedj et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Neuroinvasion of SARS-CoV-2 in human and mouse brain
- (2021) Eric Song et al. JOURNAL OF EXPERIMENTAL MEDICINE
- COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation
- (2021) Mohamed M. Aboudounya et al. MEDIATORS OF INFLAMMATION
- From SARS-CoV-2 hematogenous spreading to endothelial dysfunction: clinical-histopathological study of cutaneous signs of COVID-19
- (2021) Angela Patrì et al. Diagnostic Pathology
- Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients
- (2021) Joanna Hellmuth et al. JOURNAL OF NEUROVIROLOGY
- Characterization and Biomarker Analyses of Post-COVID-19 Complications and Neurological Manifestations
- (2021) Bing Sun et al. Cells
- The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models
- (2021) Rafal Butowt et al. ACTA NEUROPATHOLOGICA
- TLR4‐pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury
- (2021) Juliana M. Rosa et al. BRITISH JOURNAL OF PHARMACOLOGY
- SARS-CoV-2 spike protein interacts with and activates TLR41
- (2021) Yingchi Zhao et al. CELL RESEARCH
- Post-acute COVID-19 syndrome
- (2021) Ani Nalbandian et al. NATURE MEDICINE
- COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters
- (2021) Guilherme Dias de Melo et al. Science Translational Medicine
- Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study
- (2021) Daniel Ayoubkhani et al. BMJ-British Medical Journal
- Persistent neurologic symptoms and cognitive dysfunction in non‐hospitalized Covid‐19 “long haulers”
- (2021) Edith L. Graham et al. Annals of Clinical and Translational Neurology
- Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19
- (2021) Sebastian J Theobald et al. EMBO Molecular Medicine
- BoDV‐1 infection induces neuroinflammation by activating the TLR4/MyD88/IRF5 signaling pathway, leading to learning and memory impairment in rats
- (2021) Tian Tang et al. JOURNAL OF MEDICAL VIROLOGY
- Dysregulation of brain and choroid plexus cell types in severe COVID-19
- (2021) Andrew C. Yang et al. NATURE
- Long COVID in a prospective cohort of home-isolated patients
- (2021) Bjørn Blomberg et al. NATURE MEDICINE
- Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19
- (2021) Mercedes Prudencio et al. Science Translational Medicine
- Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19
- (2021) Katarzyna Bilinska et al. Frontiers in Cellular Neuroscience
- Long covid—mechanisms, risk factors, and management
- (2021) Harry Crook et al. BMJ-British Medical Journal
- A New Score Unveils a High Prevalence of Mild Cognitive Impairment in Patients with Nonalcoholic Fatty Liver Disease
- (2021) Carla Giménez-Garzó et al. Journal of Clinical Medicine
- SARS-CoV-2 spike S1 subunit induces neuroinflammatory, microglial and behavioral sickness responses: Evidence of PAMP-like properties
- (2021) Matthew G. Frank et al. BRAIN BEHAVIOR AND IMMUNITY
- SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia
- (2021) Olumayokun A. Olajide et al. MOLECULAR NEUROBIOLOGY
- Evolution of enhanced innate immune evasion by SARS-CoV-2
- (2021) Lucy G. Thorne et al. NATURE
- Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial Cells
- (2021) Eun Seon Kim et al. Viruses-Basel
- Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis
- (2021) Felicia Ceban et al. BRAIN BEHAVIOR AND IMMUNITY
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
- (2020) Chaolin Huang et al. LANCET
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
- (2020) Daniel Wrapp et al. SCIENCE
- The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease
- (2020) Martí Colom-Cadena et al. Alzheimers Research & Therapy
- Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice
- (2020) Qi Zhong et al. Molecular Brain
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- In silico studies on the comparative characterization of the interactions of SARS‐CoV‐2 spike glycoprotein with ACE‐2 receptor homologs and human TLRs
- (2020) Abhigyan Choudhury et al. JOURNAL OF MEDICAL VIROLOGY
- Inhibition of TLR4 Induces M2 Microglial Polarization and Provides Neuroprotection via the NLRP3 Inflammasome in Alzheimer’s Disease
- (2020) Weigang Cui et al. Frontiers in Neuroscience
- TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease
- (2020) Junling Yang et al. Frontiers in Immunology
- Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19)
- (2020) W. Joost Wiersinga et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19
- (2020) Nelly Kanberg et al. NEUROLOGY
- Transplacental transmission of SARS-CoV-2 infection
- (2020) Alexandre J. Vivanti et al. Nature Communications
- Discordant anti‐SARS‐CoV ‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein
- (2020) Christine J. Ko et al. JOURNAL OF CUTANEOUS PATHOLOGY
- The good, the bad, and the opportunities of the complement system in neurodegenerative disease
- (2020) Nicole D. Schartz et al. Journal of Neuroinflammation
- Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19
- (2020) Jenny Meinhardt et al. NATURE NEUROSCIENCE
- The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice
- (2020) Elizabeth M. Rhea et al. NATURE NEUROSCIENCE
- Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein
- (2020) Gerard J. Nuovo et al. Annals of Diagnostic Pathology
- The role of microglia in viral encephalitis: a review
- (2019) Zhuangzhuang Chen et al. Journal of Neuroinflammation
- Association of TLR4 with Alzheimer's disease risk and presymptomatic biomarkers of inflammation
- (2019) Justin Miron et al. Alzheimers & Dementia
- Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology
- (2019) Claire Bridel et al. JAMA Neurology
- Toll‐like receptor 4 polymorphisms in Saudi population with cardiovascular diseases
- (2019) Abdelhabib Semlali et al. Molecular Genetics & Genomic Medicine
- Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice
- (2019) Claudia P. Figueiredo et al. Nature Communications
- The Immune System Drives Synapse Loss During Lipopolysaccharide-Induced Learning and Memory Impairment in Mice
- (2019) Yi-Rong Xin et al. Frontiers in Aging Neuroscience
- Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis
- (2017) Katherine D. Shives et al. JOURNAL OF NEUROIMMUNOLOGY
- Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex
- (2017) Michele Bellesi et al. JOURNAL OF NEUROSCIENCE
- More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation
- (2016) George Hajishengallis et al. IMMUNOLOGICAL REVIEWS
- A complement–microglial axis drives synapse loss during virus-induced memory impairment
- (2016) Michael J. Vasek et al. NATURE
- Complement and microglia mediate early synapse loss in Alzheimer mouse models
- (2016) S. Hong et al. SCIENCE
- Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo
- (2015) A Yuan et al. MOLECULAR PSYCHIATRY
- TLR signaling controls lethal encephalitis in WNV-infected brain
- (2014) Amir H. Sabouri et al. BRAIN RESEARCH
- Correlation of Hippocampal Volume and Cognitive Performances in Patients with Either Mild Cognitive Impairment or Alzheimer's disease
- (2014) Guo-Ping Peng et al. CNS Neuroscience & Therapeutics
- Maternal complement C1q and increased odds for psychosis in adult offspring
- (2014) Emily G. Severance et al. SCHIZOPHRENIA RESEARCH
- Distinct Dictation of Japanese Encephalitis Virus-Induced Neuroinflammation and Lethality via Triggering TLR3 and TLR4 Signal Pathways
- (2014) Young Woo Han et al. PLoS Pathogens
- Toll-Like Receptor Signaling Pathways
- (2014) Takumi Kawasaki et al. Frontiers in Immunology
- CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
- (2013) A. B. Lopez-Rodriguez et al. CEREBRAL CORTEX
- Polymorphism −2604G>A variants in TLR4 promoter are associated with different gene expression level in peripheral blood of atherosclerotic patients
- (2013) Silvia Ferronato et al. JOURNAL OF HUMAN GENETICS
- Common Variants in Toll-Like Receptor 4 Confer Susceptibility to Alzheimer's Disease in a Han Chinese Population
- (2012) Jin-Tai Yu et al. Current Alzheimer Research
- Astrocyte-induced Synaptogenesis Is Mediated by Transforming Growth Factor β Signaling through Modulation of d-Serine Levels in Cerebral Cortex Neurons
- (2012) Luan Pereira Diniz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
- (2012) Dorothy P. Schafer et al. NEURON
- Sequence Variants of Toll Like Receptor 4 and Late-Onset Alzheimer's Disease
- (2012) Yen-Ching Chen et al. PLoS One
- Genetic association of TLR4/11367 polymorphism with late-onset Alzheimer's disease in a Han Chinese population
- (2011) Li-Zhu Wang et al. BRAIN RESEARCH
- Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma
- (2010) M. Kerkhof et al. THORAX
- The association between Toll-like receptor 4 (TLR4) polymorphisms and the risk of prostate cancer in Korean men
- (2009) Jaemann Song et al. CANCER GENETICS AND CYTOGENETICS
- Hippocampal volumes are important predictors for memory function in elderly women
- (2009) Martin A Ystad et al. BMC MEDICAL IMAGING
- Toll-like receptors in neurodegeneration
- (2008) Eitan Okun et al. BRAIN RESEARCH REVIEWS
- Hippocampal hypometabolism predicts cognitive decline from normal aging
- (2007) Lisa Mosconi et al. NEUROBIOLOGY OF AGING
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