COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation
出版年份 2021 全文链接
标题
COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation
作者
关键词
-
出版物
MEDIATORS OF INFLAMMATION
Volume 2021, Issue -, Pages 1-18
出版商
Hindawi Limited
发表日期
2021-01-16
DOI
10.1155/2021/8874339
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China
- (2020) Aiping Wu et al. Cell Host & Microbe
- Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China
- (2020) Qiurong Ruan et al. INTENSIVE CARE MEDICINE
- Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS
- (2020) Yushun Wan et al. JOURNAL OF VIROLOGY
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
- (2020) Chaolin Huang et al. LANCET
- A pneumonia outbreak associated with a new coronavirus of probable bat origin
- (2020) Peng Zhou et al. NATURE
- COVID-19 and the cardiovascular system
- (2020) Ying-Ying Zheng et al. Nature Reviews Cardiology
- Clinical Characteristics of Coronavirus Disease 2019 in China
- (2020) Wei-jie Guan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies
- (2020) Syed Faraz Ahmed et al. Viruses-Basel
- Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody
- (2020) Xiaolong Tian et al. Emerging Microbes & Infections
- The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2
- (2020) Liang Chen et al. CARDIOVASCULAR RESEARCH
- SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
- (2020) Carly G.K. Ziegler et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients
- (2020) Zhuo Zhou et al. Cell Host & Microbe
- Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure
- (2020) Evangelos J. Giamarellos-Bourboulis et al. Cell Host & Microbe
- COVID-19 and the Heart
- (2020) Akbarshakh Akhmerov et al. CIRCULATION RESEARCH
- Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts
- (2020) Luka Nicin et al. EUROPEAN HEART JOURNAL
- Reverse vaccinology approach to design a novel multi-epitope vaccine candidate against COVID-19: an in silico study
- (2020) Maryam Enayatkhani et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- In silico studies on the comparative characterization of the interactions of SARS‐CoV‐2 spike glycoprotein with ACE‐2 receptor homologs and human TLRs
- (2020) Abhigyan Choudhury et al. JOURNAL OF MEDICAL VIROLOGY
- Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19
- (2020) Jiewen Fu et al. MOLECULAR BIOLOGY REPORTS
- Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?
- (2020) Ulf Andersson et al. MOLECULAR MEDICINE
- Changes of Laboratory Cardiac Markers and Mechanisms of Cardiac Injury in Coronavirus Disease 2019
- (2020) Lin Li et al. Biomed Research International
- Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response
- (2020) Han Zhu et al. Current Cardiology Reports
- Symptomatic Protective Action of Glycyrrhizin (Licorice) in COVID-19 Infection?
- (2020) Harald Murck Frontiers in Immunology
- Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
- (2020) Xin Zou et al. Frontiers of Medicine
- Designing a multi-epitope vaccine against SARS-CoV-2: an immunoinformatics approach
- (2020) Abdus Samad et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Targeting human TLRs to combat COVID‐19: A solution?
- (2020) Ritwik Patra et al. JOURNAL OF MEDICAL VIROLOGY
- Alveolar lipids in pulmonary disease. A review
- (2020) Christina W. Agudelo et al. Lipids in Health and Disease
- Longitudinal analyses reveal immunological misfiring in severe COVID-19
- (2020) Carolina Lucas et al. NATURE
- Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report
- (2020) NEW ENGLAND JOURNAL OF MEDICINE
- Clinical characteristics of 82 cases of death from COVID-19
- (2020) Bicheng Zhang et al. PLoS One
- Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
- (2020) Jérôme Hadjadj et al. SCIENCE
- Type III interferons disrupt the lung epithelial barrier upon viral recognition
- (2020) Achille Broggi et al. SCIENCE
- A candidate multi-epitope vaccine against SARS-CoV-2
- (2020) Tamalika Kar et al. Scientific Reports
- Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2 etiologic agent of global pandemic COVID-19: an in silico approach
- (2020) M. Shaminur Rahman et al. PeerJ
- Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)
- (2020) Valentina O. Puntmann et al. JAMA Cardiology
- COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses
- (2020) Muhammad Adnan Shereen et al. Journal of Advanced Research
- Vaccine Design from the Ensemble of Surface Glycoprotein Epitopes of SARS-CoV-2: An Immunoinformatics Approach
- (2020) Noor Rahman et al. Vaccines
- Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
- (2020) Simone Cristina Soares Brandão et al. CYTOKINE & GROWTH FACTOR REVIEWS
- A novel role of nifuroxazide in attenuation of sepsis-associated acute lung and myocardial injuries; role of TLR4/NLPR3/IL-1β signaling interruption
- (2020) Ahmed E. Khodir et al. LIFE SCIENCES
- Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans
- (2020) Jeffrey Seow et al. Nature Microbiology
- Phospholipid regulation of innate immunity and respiratory viral infection
- (2019) Dennis R. Voelker et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Toll-like receptor-induced cytokines as immunotherapeutic targets in cancers and autoimmune diseases
- (2019) Mahesh Chandra Patra et al. SEMINARS IN CANCER BIOLOGY
- Ablation of Toll-like receptor 9 attenuates myocardial ischemia/reperfusion injury in mice
- (2019) Rika Kitazume-Taneike et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Activation of NLRP3 inflammasome by lymphocytic microparticles via TLR4 pathway contributes to airway inflammation
- (2019) Qian Qiu et al. EXPERIMENTAL CELL RESEARCH
- ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway
- (2019) Rensong Ye et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Effects of the TLR4/Myd88/NF-κB Signaling Pathway on NLRP3 Inflammasome in Coronary Microembolization-Induced Myocardial Injury
- (2018) Qiang Su et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Nifuroxazide, a STAT3 inhibitor, mitigates inflammatory burden and protects against diabetes-induced nephropathy in rats
- (2018) Eman Said et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Toll-like receptor 4 contributes to a myofibroblast phenotype in cardiac fibroblasts and is associated with autophagy after myocardial infarction in a mouse model
- (2018) Ruhui Yang et al. ATHEROSCLEROSIS
- Platelet TLR4 at the crossroads of thrombosis and the innate immune response
- (2018) Mirta Schattner JOURNAL OF LEUKOCYTE BIOLOGY
- Toll-like receptor 4 in acute viral infection: Too much of a good thing
- (2018) Judith Olejnik et al. PLoS Pathogens
- Angiotensin-(1–7) and Vascular Function
- (2017) Rhian M. Touyz et al. HYPERTENSION
- MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell line
- (2017) Man Luo et al. MOLECULAR IMMUNOLOGY
- Therapeutic effects of STAT3 inhibition by nifuroxazide on murine acute graft graft-vs.-host disease: Old drug, new use
- (2017) Huijie Jia et al. Molecular Medicine Reports
- The interplay between Angiotensin II, TLR4 and hypertension
- (2017) Vinicia Campana Biancardi et al. PHARMACOLOGICAL RESEARCH
- Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection
- (2017) Mathieu Iampietro et al. PLoS Pathogens
- Integration of Canonical and Noncanonical Pathways in TLR4 Signaling: Complex Regulation of the Wound Repair Program
- (2017) Paula J. McKeown-Longo et al. Advances in Wound Care
- Toll-Like Receptor-4 Signaling Drives Persistent Fibroblast Activation and Prevents Fibrosis Resolution in Scleroderma
- (2017) Swati Bhattacharyya et al. Advances in Wound Care
- TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review
- (2016) Suprabhat Mukherjee et al. Brazilian Journal of Infectious Diseases
- Viral Myocarditis and Dilated Cardiomyopathy: Etiology and Pathogenesis
- (2016) Sally A. Huber CURRENT PHARMACEUTICAL DESIGN
- Inflammatory and fibrotic responses of cardiac fibroblasts to myocardial damage associated molecular patterns (DAMPs)
- (2016) Neil A. Turner JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation
- (2016) Monica Molteni et al. MEDIATORS OF INFLAMMATION
- Novel strategies for targeting innate immune responses to influenza
- (2016) K A Shirey et al. Mucosal Immunology
- Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases
- (2016) B. García Bueno et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Evolution of surfactant therapy for respiratory distress syndrome: past, present and future
- (2016) Smeeta Sardesai et al. PEDIATRIC RESEARCH
- Corticosteroids
- (2016) Sivapriya Ramamoorthy et al. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
- The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism
- (2016) Yi Wang et al. mBio
- The emerging role of Toll-like receptor 4 in myocardial inflammation
- (2016) Y Yang et al. Cell Death & Disease
- TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism
- (2016) Xingying He et al. Scientific Reports
- HMGB1 Neutralizing Antibody Attenuates Cardiac Injury and Apoptosis Induced by Hemorrhagic Shock/Resuscitation in Rats
- (2015) Yu Zhou et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Toll-like receptor 4 promotes fibrosis in bleomycin-induced lung injury in mice
- (2015) X.X. Li et al. GENETICS AND MOLECULAR RESEARCH
- Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection
- (2015) Allison L. Totura et al. mBio
- Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1
- (2014) Yun-peng Luo et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Cardiac Fibroblasts Contribute to Myocardial Dysfunction in Mice with Sepsis: The Role of NLRP3 Inflammasome Activation
- (2014) Wenbo Zhang et al. PLoS One
- Calcium signaling and mitochondrial destabilization in the triggering of the NLRP3 inflammasome
- (2014) Tiffany Horng TRENDS IN IMMUNOLOGY
- Immunomodulatory activity of interferon-beta
- (2014) Lloyd H. Kasper et al. Annals of Clinical and Translational Neurology
- Suppression of TLR-4-Related Inflammatory Pathway and Anti-Fibrosis Effects of Probiotic-Fermented Purple Sweet Potato Yogurt in Hearts of Spontaneously Hypertensive Rats
- (2013) CHINESE JOURNAL OF PHYSIOLOGY
- TLR2 and TLR4 in Autoimmune Diseases: a Comprehensive Review
- (2013) Yu Liu et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- Pathogenesis of influenza-induced acute respiratory distress syndrome
- (2013) Kirsty R Short et al. LANCET INFECTIOUS DISEASES
- Protein Kinase C -Calcineurin Cosignaling Downstream of Toll-Like Receptor 4 Downregulates Fibrosis and Induces Wound Healing Gene Expression in Cardiac Myofibroblasts
- (2013) R. F. D. S. Mesquita et al. MOLECULAR AND CELLULAR BIOLOGY
- The TLR4 antagonist Eritoran protects mice from lethal influenza infection
- (2013) Kari Ann Shirey et al. NATURE
- Surfactant Replacement Therapy for Preterm and Term Neonates With Respiratory Distress
- (2013) Richard A. Polin et al. PEDIATRICS
- Differential Response of Primary Alveolar Type I and Type II Cells to LPS Stimulation
- (2013) Mandi H. Wong et al. PLoS One
- Make Yourself at Home: Viral Hijacking of the PI3K/Akt Signaling Pathway
- (2013) Nora Diehl et al. Viruses-Basel
- Diverse Functions of Pulmonary Collectins in Host Defense of the Lung
- (2012) Shigeru Ariki et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Diagnosis and Treatment of Viral Myocarditis
- (2012) Jason C. Schultz et al. MAYO CLINIC PROCEEDINGS
- Lipopolysaccharide Induces Lung Fibroblast Proliferation through Toll-Like Receptor 4 Signaling and the Phosphoinositide3-Kinase-Akt Pathway
- (2012) Zhengyu He et al. PLoS One
- CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4
- (2011) Ivan Zanoni et al. CELL
- Local Renin-Angiotensin II Systems, Angiotensin-Converting Enzyme and its Homologue ACE2: Their Potential Role in the Pathogenesis of Chronic Obstructive Pulmonary Diseases, Pulmonary Hypertension and Acute Respiratory Distress Syndrome
- (2011) A. Kaparianos et al. CURRENT MEDICINAL CHEMISTRY
- The toll-like receptor 4-antagonist eritoran reduces murine cardiac hypertrophy
- (2011) Heidi Ehrentraut et al. EUROPEAN JOURNAL OF HEART FAILURE
- TRIF Is a Critical Survival Factor in Viral Cardiomyopathy
- (2011) A. Riad et al. JOURNAL OF IMMUNOLOGY
- Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction
- (2011) Gemma Vilahur et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway
- (2011) Leonid Tarassishin et al. Journal of Neuroinflammation
- Interferon-stimulated genes and their antiviral effector functions
- (2011) John W Schoggins et al. Current Opinion in Virology
- Psoriasis and extra domain A fibronectin loops
- (2010) J.P. McFadden et al. BRITISH JOURNAL OF DERMATOLOGY
- Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts
- (2010) J. P. Burke et al. BRITISH JOURNAL OF SURGERY
- A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*
- (2010) Todd W. Rice et al. CRITICAL CARE MEDICINE
- Effect of Toll-like receptor 4 inhibitor on LPS-induced lung injury
- (2010) Hiroyuki Seki et al. INFLAMMATION RESEARCH
- TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules
- (2010) N. Matsunaga et al. MOLECULAR PHARMACOLOGY
- A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
- (2010) H. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pulmonary Surfactant: An Immunological Perspective
- (2009) Zissis Chroneos et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Anionic Pulmonary Surfactant Phospholipids Inhibit Inflammatory Responses from Alveolar Macrophages and U937 Cells by Binding the Lipopolysaccharide-interacting Proteins CD14 and MD-2
- (2009) Koji Kuronuma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains
- (2009) Wondwossen Abate et al. JOURNAL OF LIPID RESEARCH
- Critical role of extracellular heat shock cognate protein 70 in the myocardial inflammatory response and cardiac dysfunction after global ischemia-reperfusion
- (2008) Ning Zou et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury
- (2008) Yumiko Imai et al. CELL
- TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
- (2008) Jonathan C Kagan et al. NATURE IMMUNOLOGY
- MyD88 Is Required for Protection from Lethal Infection with a Mouse-Adapted SARS-CoV
- (2008) Timothy Sheahan et al. PLoS Pathogens
- Toll-Like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction
- (2007) Leo Timmers et al. CIRCULATION RESEARCH
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started