ZYG11B potentiates the antiviral innate immune response by enhancing cGAS-DNA binding and condensation

PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation

(2022) Haiyan Gu et al.   Nature Communications

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing

(2021) Wen Zhou et al.   MOLECULAR CELL

Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response

(2021) Dapeng Ma et al.   Science Advances

Molecular basis for recognition of Gly/N-degrons by CRL2ZYG11B and CRL2ZER1

(2021) Xiaojie Yan et al.   MOLECULAR CELL

The stress granule protein G3BP1 promotes pre‐condensation of cGAS to allow rapid responses to DNA

(2021) Ming Zhao et al.   EMBO REPORTS

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

(2020) Peiguo Yang et al.   CELL

PCBP1 modulates the innate immune response by facilitating the binding of cGAS to DNA

(2020) Chen-Yang Liao et al.   Cellular & Molecular Immunology

Cytosine Methylation Enhances DNA Condensation Revealed by Equilibrium Measurements Using Magnetic Tweezers

(2020) Ya-Jun Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular mechanisms and cellular functions of cGAS–STING signalling

(2020) Karl-Peter Hopfner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response

(2020) Mi Li et al.   Protein & Cell

Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway

(2020) Xuewu Zhang et al.   IMMUNITY

cGAS-STING pathway in cancer biotherapy

(2020) Yang Wang et al.   Molecular Cancer

KAT5 acetylates cGAS to promote innate immune response to DNA virus

(2020) Ze-Min Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BAF restricts cGAS on nuclear DNA to prevent innate immune activation

(2020) Baptiste Guey et al.   SCIENCE

DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity

(2020) Xiaona Sun et al.   Nature Communications

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

Structural basis of STING binding with and phosphorylation by TBK1

(2019) Conggang Zhang et al.   NATURE

A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation

(2019) Richard T. Timms et al.   SCIENCE

Regulation of cGAS- and RLR-mediated immunity to nucleic acids

(2019) Andrea Ablasser et al.   NATURE IMMUNOLOGY

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

(2018) Tuo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response

(2018) Huan Lian et al.   Nature Communications

G3BP1 promotes DNA binding and activation of cGAS

(2018) Zhao-Shan Liu et al.   NATURE IMMUNOLOGY

SG formation relies on eIF4GI-G3BP interaction which is targeted by picornavirus stress antagonists

(2018) Xiaodan Yang et al.   Cell Discovery

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

(2017) Liudmila Andreeva et al.   NATURE

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

(2017) Jessica F. Almine et al.   Nature Communications

The ubiquitin ligase CRL2 ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage

(2016) Riju S. Balachandran et al.   JOURNAL OF CELL BIOLOGY

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

(2016) Pengyan Xia et al.   NATURE IMMUNOLOGY

PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1

(2015) Sunnie M. Yoh et al.   CELL

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange

(2015) Yidan Ding et al.   NATURE METHODS

Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

(2015) Daxing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

(2015) Gil Ju Seo et al.   Cell Reports

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Two distinct overstretched DNA structures revealed by single-molecule thermodynamics measurements

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Dimerization-Dependent Green and Yellow Fluorescent Proteins

(2012) Spencer C. Alford et al.   ACS Synthetic Biology

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE