Activity-Based Protein Profiling: Recent Advances in Probe Development and Applications

Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

(2014) Micah J. Niphakis et al.   Annual Review of Biochemistry

“Minimalist” Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling

(2014) Zhengqiu Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling

(2013) Zhengqiu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activity-Based Imaging Probes of the Proteasome

(2013) Kimberly Cornish Carmony et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Activity-Based Probes for Studying the Activity of Flavin-Dependent Oxidases and for the Protein Target Profiling of Monoamine Oxidase Inhibitors

(2012) Joanna M. Krysiak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities

(2012) Lianne I. Willems et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Imaging of Aurora Kinase A in Live Cells

(2012) Katherine S. Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Duocarmycin Analogues Target Aldehyde Dehydrogenase 1 in Lung Cancer Cells

(2012) Tanja Wirth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Live-Cell Imaging of Cyclopropene Tags with Fluorogenic Tetrazine Cycloadditions

(2012) Jun Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preventing Thiol-Yne Addition Improves the Specificity of Strain-Promoted Azide–Alkyne Cycloaddition

(2012) Remon van Geel et al.   BIOCONJUGATE CHEMISTRY

Rugulactone and its Analogues Exert Antibacterial Effects through Multiple Mechanisms Including Inhibition of Thiamine Biosynthesis

(2012) Matthew B. Nodwell et al.   CHEMBIOCHEM

Design, Synthesis and Biological Evaluation of Potent Azadipeptide Nitrile Inhibitors and Activity-Based Probes as Promising Anti-Trypanosoma bruceiAgents

(2012) Peng-Yu Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

(2012) Haibin Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective Targeting of Distinct Active Site Nucleophiles by Irreversible Src-Family Kinase Inhibitors

(2012) Nathan N. Gushwa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functionalized Cyclopropenes As Bioorthogonal Chemical Reporters

(2012) David M. Patterson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Active site profiling reveals coupling between domains in SRC-family kinases

(2012) Ratika Krishnamurty et al.   Nature Chemical Biology

Development of Activity-Based Probes for Cathepsin X

(2011) Margot G. Paulick et al.   ACS Chemical Biology

Quantitative, High-Resolution Proteomics for Data-Driven Systems Biology

(2011) Jürgen Cox et al.   Annual Review of Biochemistry

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

(2011) Haibin Shi et al.   CHEMICAL COMMUNICATIONS

Dihydroisoxazole Analogs for Labeling and Visualization of Catalytically Active Transglutaminase 2

(2011) Laila Dafik et al.   CHEMISTRY & BIOLOGY

A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases

(2011) Dante Rotili et al.   CHEMISTRY & BIOLOGY

Chemical Modification and Organelle-Specific Localization of Orlistat-Like Natural-Product-Based Probes

(2011) Peng-Yu Yang et al.   Chemistry-An Asian Journal

Applying Small Molecule Microarrays and Resulting Affinity Probe Cocktails for Proteome Profiling of Mammalian Cell Lysates

(2011) Haibin Shi et al.   Chemistry-An Asian Journal

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes

(2011) Laura E Edgington et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification of a Lacosamide Binding Protein Using an Affinity Bait and Chemical Reporter Strategy: 14-3-3 ζ

(2011) Ki Duk Park et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unraveling the Protein Targets of Vancomycin in Living S. aureus and E. faecalis Cells

(2011) Jürgen Eirich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diels–Alder Cycloaddition for Fluorophore Targeting to Specific Proteins inside Living Cells

(2011) Daniel S. Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

(2011) D. A. Bachovchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast two-hybrid methods and their applications in drug discovery

(2011) Amel Hamdi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Bioorthogonal Turn-On Probes for Imaging Small Molecules inside Living Cells

(2010) Neal K. Devaraj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Chloroacetamidine-Based Inactivator of Protein Arginine Methyltransferase 1: Design, Synthesis, and In Vitro and In Vivo Evaluation

(2010) Obiamaka Obianyo et al.   CHEMBIOCHEM

Click-based synthesis and proteomic profiling of lipstatin analogues

(2010) Mun H. Ngai et al.   CHEMICAL COMMUNICATIONS

Activity-based Proteomics of Enzyme Superfamilies: Serine Hydrolases as a Case Study

(2010) Gabriel M. Simon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Showdomycin as a Versatile Chemical Tool for the Detection of Pathogenesis-Associated Enzymes in Bacteria

(2010) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activity-Based Probes That Target Functional Subclasses of Phospholipases in Proteomes

(2010) Sarah E. Tully et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Generating and navigating proteome maps using mass spectrometry

(2010) Christian H. Ahrens et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activity-based protein profiling of the hepatitis C virus replication in Huh-7 hepatoma cells using a non-directed active site probe

(2010) Ragunath Singaravelu et al.   Proteome Science

Next Generation Chemical Proteomic Tools for Rapid Enzyme Profiling

(2009) Mahesh Uttamchandani et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition

(2009) Neal K. Devaraj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional Profiling, Identification, and Inhibition of Plasmepsins in Intraerythrocytic Malaria Parasites

(2009) Kai Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expedient solid-phase synthesis of both symmetric and asymmetric diol libraries targeting aspartic proteases

(2009) Haibin Shi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small molecule microarray-facilitated screening of affinity-based probes (AfBPs) for γ-secretase

(2009) Haibin Shi et al.   CHEMICAL COMMUNICATIONS

Small molecule probes that target Ablkinase

(2009) Karunakaran A. Kalesh et al.   CHEMICAL COMMUNICATIONS

Peptide-based activity-based probes (ABPs) for target-specific profiling of proteintyrosine phosphatases (PTPs)

(2009) Karunakaran A. Kalesh et al.   CHEMICAL COMMUNICATIONS

Chemical Probes Identify a Role for Histone Deacetylase 3 in Friedreich's Ataxia Gene Silencing

(2009) Chunping Xu et al.   CHEMISTRY & BIOLOGY

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

A Click Chemistry Mediatedin VivoActivity Probe for Dimethylarginine Dimethylaminohydrolase

(2009) Yun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Suite of Activity-Based Probes for Human Cytochrome P450 Enzymes

(2009) Aaron T. Wright et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactam Probes As Selective Chemical-Proteomic Tools for the Identification and Functional Characterization of Resistance Associated Enzymes in MRSA

(2009) Isabell Staub et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

(2009) Peng-Yu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-directed tosyl chemistry for protein labeling in vivo

(2009) Shinya Tsukiji et al.   Nature Chemical Biology

Rapid synthesis of Abelson tyrosine kinase inhibitors using click chemistry

(2009) Karunakaran A. Kalesh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

High-throughput synthesis of azide libraries suitable for direct “click” chemistry and in situ screening

(2009) Rajavel Srinivasan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

High-Throughput Discovery ofMycobacterium tuberculosisProtein Tyrosine Phosphatase B (MptpB) Inhibitors Using Click Chemistry

(2009) Lay Pheng Tan et al.   ORGANIC LETTERS

β-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes

(2008) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging

(2008) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

Chemical probes for profiling fatty acid-associated proteins in living cells

(2008) Anuradha Raghavan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An Improved Mechanism-Based Cross-Linker for Multiplexed Kinase Detection and Inhibition in a Complex Proteome

(2008) Kai Liu et al.   CHEMBIOCHEM

Optimization of Activity-Based Probes for Proteomic Profiling of Histone Deacetylase Complexes

(2008) Cleo M. Salisbury et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence

(2008) Isabell Staub et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors ofStaphylococcus aureus

(2008) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In-cell Selectivity Profiling of Serine Protease Inhibitors by Activity-based Proteomics

(2008) Ludovic C. J. Gillet et al.   MOLECULAR & CELLULAR PROTEOMICS

Solid-Phase Assembly and In Situ Screening of Protein Tyrosine Phosphatase Inhibitors

(2008) Rajavel Srinivasan et al.   ORGANIC LETTERS

Solid-Phase Synthesis of Azidomethylene Inhibitors Targeting Cysteine Proteases

(2008) Peng-Yu Yang et al.   ORGANIC LETTERS

In Situ “Click” Assembly of Small Molecule Matrix Metalloprotease Inhibitors Containing Zinc-Chelating Groups

(2008) Mingyu Hu et al.   ORGANIC LETTERS