Article
Chemistry, Organic
Huan Xiong, Jianping Wu, Hua-Li Qin
Summary: This article presents a method for the construction of indolizine-based heterocyclic sulfonyl fluorides through [3 + 2] cycloaddition reaction. The method features mild conditions, high efficiency, easily obtained starting materials, and a broad substrate scope, which holds great potential value in medicinal chemistry and other related disciplines.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Florian Mahler, Annette Meister, Carolyn Vargas, Gregory Durand, Sandro Keller
Summary: The use of specific amphiphilic molecules can directly assemble lipids and membrane proteins to form native nanodiscs, rather than mixed micelles. Detailed investigation into the lipid bilayer integrity and membrane protein activity in these nanodiscs reveals gentle effects.
Article
Polymer Science
Qingliang Song, Qingshu Dong, Xue-Hui Dong, You-Liang Zhu, Weihua Li
Summary: The self-assembly of amphiphiles containing giant monomers of the cubic cage was studied using DPD simulations. The presence of giant monomers significantly influenced the structure and phase behavior, leading to changes in morphology types and phase boundaries.
Article
Chemistry, Organic
Hong-Ru Chen, Zhen-Yu Hu, Hua-Li Qin, Haolin Tang
Summary: A copper-catalyzed three-component reaction has been developed for the transformation of quinolines, isoquinolines, and pyridines to a novel class of alkyl sulfonyl fluorides containing indolizine moiety. The method features mild reaction conditions, wide substrate scope, excellent functional group compatibility, and high atom and step economy.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Physical
Nan Ye, Yi-rong Pei, Qingqing Han, Long Yi Jin
Summary: Stimuli-responsive assembly and reversible light-mediated morphological alterations were observed in rod-coil amphiphilic compounds containing spiropyran groups in a solution system with 99% water content. UV irradiation caused the initial assemblies to deform or disassemble, while the removal of UV source led to the gradual recovery of the original nanostructures through the ring-closing reaction process. These compounds can selectively combine with copper ions and emit bright blue fluorescence, enabling the specific visual identification of copper ions in aqueous solutions.
Article
Chemistry, Medicinal
Diana Mironova, Egor Makarov, Islamiya Bilyukova, Kevser Akyol, Elsa Sultanova, Vladimir Evtugyn, Damir Davletshin, Elvina Gilyazova, Emil Bulatov, Vladimir Burilov, Svetlana Solovieva, Igor Antipin
Summary: The study focuses on investigating the aggregation and complexing properties of calixarenes as potential DNA condensation agents for gene delivery. Triazole derivatives of calix[4]arenes 7 and 8 containing monoammonium fragments were synthesized and characterized. The interactions between these compounds and calf thymus DNA were studied, and the cytotoxic properties against cancerous cells were evaluated. Compound 4 showed the highest toxic effect on MCF7 breast adenocarcinoma.
Article
Biochemistry & Molecular Biology
Yucen Tao, Xia Hao, Lanlan Jing, Lin Sun, Srinivasulu Cherukupalli, Shugong Liu, Gaochan Wu, Shujing Xu, Xujie Zhang, Xiaoyu Shi, Yuning Song, Xinyong Liu, Peng Zhan
Summary: The study utilized miniaturized synthesis to generate quinonoid-focused libraries and screening led to the discovery of potent and selective Cdc25 inhibitors, with compound M5N36 showing higher inhibitory activity against Cdc25C. Mechanistic understanding of M5N36's activity was provided through cell viability evaluation, western blotting, and molecular simulations, showing promising anti-growth activity and desirable physicochemical properties against the MDA-MB-231 cell line. Overall, M5N36 was proven to be a promising novel Cdc25C inhibitor.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Valeria Pingitore, Macarena Martinez-Bailen, Ana T. Carmona, Zuzana Meszaros, Natalia Kulik, Kristyna Slamova, Vladimir Kren, Pavla Bojarova, Inmaculada Robina, Antonio J. Moreno-Vargas
Summary: Two libraries of mono- and dimeric pyrrolidine iminosugars were synthesized and screened for inhibition of enzymes from Jack beans and human lysosomal hexosaminidases, resulting in the identification of potent and selective inhibitors for human nucleocytoplasmic beta-N-acetylglucosaminidase.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Khaled Hriz, Safa Teka, Habiba Zrida, Samar Gharbi, Walaa Ibrahim El Sofany, Achref Jebnouni, Mustapha Majdoub
Summary: This paper introduces a new type of soluble and filmogenic conjugated polymers (PAnSCN and PAnSCN-Tet) for heavy metal sensing applications. The materials are based on the anthracene chromophore and contain tetrazole and/or cyanide groups in their molecular chain backbones. The study investigates the effect of electron withdrawing groups on the photophysical properties and chelating abilities of the organic materials. The synthesized polymers were studied as optical sensors, showing significant decrease in photoluminescence responses with Mn2+ cations, with better sensitivity and selectivity observed in the case of PAnSCN-Tet.
Article
Chemistry, Multidisciplinary
Jiandong Wan, Rui Wang, Zixiang Liu, Longhai Zhang, Fei Liang, Tengfei Zhou, Shilin Zhang, Lin Zhang, Qiquan Lu, Chaofeng Zhang, Zaiping Guo
Summary: Sodium tartrate is used as a dual-functional electrolyte additive to improve the reversibility of aqueous zinc-ion batteries. The additive preferentially adsorbs on the zinc surface, coordinates with zinc ions, and promotes uniform zinc deposition on the (002) plane, inhibiting side reactions and dendrite growth. This leads to long-term cycling stability and improved performance of zinc||MnO2 full cells.
Article
Chemistry, Physical
Shuaijia Yang, Peng Zou, Yu Wang, Rui Song, Zhenyu Chen
Summary: A novel in-situ self-assembled film was prepared on the copper surface via a click chemistry reaction. The formation of the film was confirmed by various spectroscopy analyses, and its corrosion inhibition ability was evaluated using electrochemical methods. The results showed that the film exhibited high corrosion inhibition efficiency, which was attributed to the formation of a C-S bond.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Medicinal
Mingze Qin, Yangyang Meng, Haoshen Yang, Lei Liu, Haotian Zhang, Simeng Wang, Chunyang Liu, Xia Wu, Di Wu, Ye Tian, Yunlei Hou, Yanfang Zhao, Yajing Liu, Congjun Xu, Lihui Wang
Summary: In this study, new 4-arylindolines containing a thiazole moiety were developed through structural modification, with compound A30 showing promising modulation of the PD-1/PD-L1 axis by promoting IFN-gamma secretion and rescuing T-cell proliferation. Furthermore, A30 demonstrated favorable in vivo antitumor activity in mouse models and inhibited tumor growth by activating the immune microenvironment, suggesting its potential as a starting point for further development of PD-1/PD-L1 interaction inhibitors as antitumor agents.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Optics
Jiayu Liu, Siyu Liu, Pengtao Ma, Jingping Wang, Jingyang Niu
Summary: Three new organic-inorganic hybrid lanthanide-substituted organophosphonate-based polyoxomolybdates were successfully synthesized and characterized. Their special structural feature is a tetrameric ring-shaped structure formed by four [Mo5O15(1,4-O3PCH2C6H4CH2PO3)]4- units, connected by Nd3+ ions into a one-dimensional mesh structure form.
JOURNAL OF LUMINESCENCE
(2023)
Article
Biochemistry & Molecular Biology
Krystian Pyta, Natalia Skrzypczak, Piotr Ruszkowski, Franz Bartl, Piotr Przybylski
Summary: The influence of base type, temperature, and solvent on the regioselective click modifications of colchiceine is investigated in this study. New ether derivatives enable the assembly of the alkaloid part with heterocycles or important biomolecules, resulting in hybrid scaffolds with improved or similar anticancer effects compared to colchicine or colchiceine. The substitution pattern and bulkiness of the substituents in the tropolone ring are found to be essential for the improved effects. Docking of the derivatives into the colchicine pocket reveals a relationship between the binding mode and the anticancer potency.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Kupinska, Maciej Michalik, Justyna Krajenta, Magda Bielicka, Karolina Halina Markiewicz, Beata Kalska-Szostko, Agnieszka Zofia Wilczewska
Summary: This study investigated the methods of preparation of zinc oxide-polypropylene nanocomposites and their antibacterial properties. Two methods of ZnO NPs syntheses were carried out and the influence of various factors on the synthesis process was examined. The fabricated PP-ZnO composite showed antibacterial properties against Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Junqi Li, Anthony S. Grillo, Martin D. Burke
ACCOUNTS OF CHEMICAL RESEARCH
(2015)
Article
Multidisciplinary Sciences
Junqi Li, Steven G. Ballmer, Eric P. Gillis, Seiko Fujii, Michael J. Schmidt, Andrea M. E. Palazzolo, Jonathan W. Lehmann, Greg F. Morehouse, Martin D. Burke
Review
Biochemistry & Molecular Biology
Mahesh Uttamchandani, Junqi Li, Hongyan Sun, Shao Q. Yao
Article
Chemistry, Multidisciplinary
Junqi Li, Martin D. Burke
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2011)
Article
Chemistry, Organic
Junqi Li, Shao Q. Yao
Article
Chemistry, Organic
Junqi Li, Mingyu Hu, Shao Q. Yao
Article
Chemistry, Multidisciplinary
Yongseok Kwon, Junqi Li, Jolene P. Reid, Jennifer M. Crawford, Roxane Jacob, Matthew S. Sigman, F. Dean Toste, Scott J. Miller
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)
Article
Multidisciplinary Sciences
Jonathan W. Lehmann, Ian T. Crouch, Daniel J. Blair, Melanie Trobe, Pulin Wang, Junqi Li, Martin D. Burke
NATURE COMMUNICATIONS
(2019)
Article
Chemistry, Physical
Junqi Li, Samantha Grosslight, Scott J. Miller, Matthew S. Sigman, F. Dean Toste
Article
Chemistry, Multidisciplinary
Quang H. Luu, Junqi Li
Summary: This study presents a new reaction strategy for carbon-to-oxygen substitution in the core framework of complex molecules, enabling single atom changes. The oxygen atom insertion is achieved through methylene and Baeyer-Villiger oxidations, followed by a nickel-catalyzed decarbonylation to remove the carbon atom. This reaction sequence was successfully applied to various lactones, and also demonstrated on a natural product and a pharmaceutical precursor.
Article
Chemistry, Organic
Tian You, Junqi Li
Summary: In this study, a C-N cross-coupling reaction using Ni(cod)(DQ) as a catalyst without additional ligands was reported. This method enables the synthesis of N,N-diarylsulfonamides from weakly nucleophilic N-arylsulfonamides and aryl bromides. The reaction is compatible with a wide range of electron-deficient and electron-rich aryl and heteroaryl bromides and can be applied to the derivatization of N-arylsulfonamide pharmaceutical compounds.
Article
Chemistry, Physical
Shengkai Wei, Liang-Yu Chen, Junqi Li
Summary: In this study, an enantioselective Pd-catalyzed C-O bond-forming macrocyclization was developed to access enantioenriched planar chiral macrocyclic metacyclophanes incorporating 2,3,4-trisubstituted pyridines. Various bridging chains and substituents were successfully incorporated into the metacyclophanes under the same reaction conditions. The syn-/anti-conformational preferences of the metacyclophanes were determined through structural, spectroscopic, and computational studies. This work provides a new strategy for the design of enantioselective cross-coupling macrocyclizations for the synthesis of planar chiral structures with potential applications in medicinal chemistry and catalysis.
Article
Chemistry, Organic
Liang-Yu Chen, Junqi Li
Summary: The skeletal editing of dibenzolactones to fluorenes by Ni- or Pd-catalyzed decarboxylation is reported. The reaction does not require inductively electron-withdrawing ortho substituents on the aryl carboxylate moiety and metal additives. The mechanism involves the stabilization of the carboxylate-ligated Ni complex over the Ni-carboxylate ion pair.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mahesh Uttamchandani, Jun Wang, Junqi Li, Mingyu Hu, Hongyan Sun, Kitty Y. -T. Chen, Kai Liu, Shao Q. Yao
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2007)
