PPARG: A Promising Therapeutic Target in Breast Cancer and Regulation by Natural Drugs

The Role of PPARs in Breast Cancer

(2022) Binggong Zhao et al.   Cells

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action

(2021) Miguel Hernandez-Quiles et al.   Frontiers in Endocrinology

Quercetin against MCF7 and CAL51 breast cancer cell lines: apoptosis, gene expression and cytotoxicity of nano-quercetin

(2021) Hamdoon A Mohammed et al.   Nanomedicine

The PPARα and PPARγ Epigenetic Landscape in Cancer and Immune and Metabolic Disorders

(2021) Jesús Porcuna et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ

(2020) Jing Zhou et al.   Cancer Research and Treatment

Overcoming Endocrine Resistance in Breast Cancer

(2020) Ariella B. Hanker et al.   CANCER CELL

Peroxisome Proliferator-Activated Receptors: Experimental Targeting for the Treatment of Inflammatory Bowel Diseases

(2020) Juan Decara et al.   Frontiers in Pharmacology

Characterization of Glycolysis-Associated Molecules in the Tumor Microenvironment Revealed by Pan-Cancer Tissues and Lung Cancer Single Cell Data

(2020) Jinfen Wei et al.   Cancers

MicroRNA-98 reduces nerve growth factor expression in nicotine-induced airway remodeling

(2020) Cherry Wongtrakool et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the activation of γδT17 cells through PPARγ–PTEN/Akt/GSK3β/NFAT pathway contributes to the anti-colitis effect of madecassic acid

(2020) Xinming Yun et al.   Cell Death & Disease

VSP‑17 suppresses the migration and invasion of triple‑negative breast cancer cells through inhibition of the EMT process via the PPARγ/AMPK signaling pathway

(2020) Xiaotian Xu et al.   ONCOLOGY REPORTS

Prostaglandin A1 Inhibits the Cognitive Decline of APP/PS1 Transgenic Mice via PPARγ/ABCA1-dependent Cholesterol Efflux Mechanisms

(2019) Guo-Biao Xu et al.   Neurotherapeutics

Quercetin protects against atherosclerosis by regulating the expression of PCSK9, CD36, PPARγ, LXRα and ABCA1

(2019) Qingling Jia et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Anti-Cancer Effect of Quercetin: Molecular Implications in Cancer Metabolism

(2019) Marjorie Reyes-Farias et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combinational applicaton of silybin and tangeretin attenuates the progression of non-alcoholic steatohepatitis (NASH) in mice via modulating lipid metabolism

(2019) Rinkiko Suguro et al.   PHARMACOLOGICAL RESEARCH

Vanillic acid attenuates obesity via activation of the AMPK pathway and thermogenic factors in vivo and in vitro

(2018) Yunu Jung et al.   FASEB JOURNAL

Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling

(2018) Xin Zhang et al.   Cell Death & Disease

Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway

(2018) Ying Lu et al.   Cell Death & Disease

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation

(2018) Young-Lai Cho et al.   PHARMACOLOGICAL RESEARCH

Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration

(2018) Young Mi Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARγ/AMPK/ACC1 pathway

(2017) Xiaotian Xu et al.   Cell Death & Disease

Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways

(2017) Zhen-Guo Ma et al.   EBioMedicine

An update on PPAR activation by cannabinoids

(2016) Saoirse Elizabeth O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol protects an in vitro model of the blood-brain barrier from oxygen-glucose deprivation via PPARγ and 5-HT1A receptors

(2016) William H Hind et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chrysin, a PPAR-γ agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation

(2016) Neha Rani et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cascade regulation of PPARγ2 and C/EBPα signaling pathways by celastrol impairs adipocyte differentiation and stimulates lipolysis in 3T3-L1 adipocytes

(2016) Seung Kug Choi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization

(2016) Xiujing Feng et al.   EBioMedicine

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

(2015) Jie-Qiong Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis

(2015) Haiyan Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-to-mesenchymal transition

(2015) Shing-Hwa Liu et al.   Molecular Oncology

Inhibitory effects of tannic acid in the early stage of 3T3-L1 preadipocytes differentiation by down-regulating PPARγ expression

(2015) Fangyuan Nie et al.   Food & Function

Novel modulators of hepatosteatosis, inflammation and fibrogenesis

(2014) M. Raj Lakshman et al.   Hepatology International

The Chemistry of Curcumin: From Extraction to Therapeutic Agent

(2014) Kavirayani Priyadarsini   MOLECULES

Treatment with resveratrol attenuates sublesional bone loss in spinal cord-injured rats

(2013) Hua-Dong Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

6-Shogaol inhibits breast and colon cancer cell proliferation through activation of peroxisomal proliferator activated receptor γ (PPARγ)

(2013) Boon Shing Tan et al.   CANCER LETTERS

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

Tauroursodeoxycholic Acid Affects PPARγ and TLR4 in Steatotic Liver Transplantation

(2012) M. B. Jiménez-Castro et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Curcumin ameliorates hepatic fibrosis in type 2 diabetes mellitus - insights into its mechanisms of action

(2012) B Stefanska   BRITISH JOURNAL OF PHARMACOLOGY

Blockade of adipocyte differentiation by cordycepin

(2012) Shuhei Takahashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Salvianolic acid B suppresses maturation of human monocyte-derived dendritic cells by activating PPARγ

(2011) Aijun Sun et al.   BRITISH JOURNAL OF PHARMACOLOGY

The green tea polyphenol (−)-epigallocatechin-3-gallate ameliorates experimental immune-mediated glomerulonephritis

(2011) Ai Peng et al.   KIDNEY INTERNATIONAL

Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor   or Retinoid X Receptor   Deficiency

(2010) T. Roszer et al.   JOURNAL OF IMMUNOLOGY

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

(2010) Jun Wei et al.   PLoS One

The Peroxisome Proliferator-Activated Receptor  /Retinoid X Receptor   Heterodimer Targets the Histone Modification Enzyme PR-Set7/Setd8 Gene and Regulates Adipogenesis through a Positive Feedback Loop

(2009) K.-i. Wakabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

(2008) Bharat B. Aggarwal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY