Prostaglandin A1 Inhibits the Cognitive Decline of APP/PS1 Transgenic Mice via PPARγ/ABCA1-dependent Cholesterol Efflux Mechanisms

Magnesium Ions Inhibit the Expression of Tumor Necrosis Factor α and the Activity of γ-Secretase in a β-Amyloid Protein-Dependent Mechanism in APP/PS1 Transgenic Mice

(2018) Xin Yu et al.   Frontiers in Molecular Neuroscience

Cholesterol and Late-Life Cognitive Decline

(2018) Peter van Vliet   JOURNAL OF ALZHEIMERS DISEASE

miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis

(2017) Maren Diepenbruck et al.   Nature Communications

Prostaglandin I2upregulates the expression of anterior pharynx-defective-1α and anterior pharynx-defective-1β in amyloid precursor protein/presenilin 1 transgenic mice

(2016) Pu Wang et al.   AGING CELL

Prostaglandin J2: a potential target for halting inflammation-induced neurodegeneration

(2016) Maria E. Figueiredo-Pereira et al.   Annals of the New York Academy of Sciences

Membrane raft domains and remodeling in aging brain

(2016) Julie Colin et al.   BIOCHIMIE

By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice

(2015) Xin Yu et al.   FASEB JOURNAL

Therapeutic implications of the prostaglandin pathway in Alzheimer's disease

(2014) Eiron Cudaback et al.   BIOCHEMICAL PHARMACOLOGY

Cholesterol Homeostasis Failure in the Brain: Implications for Synaptic Dysfunction and Cognitive Decline

(2014) Marco Segatto et al.   CURRENT MEDICINAL CHEMISTRY

Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

(2014) Jenny U. Johansson et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions

(2014) Claire L. Gibson et al.   JOURNAL OF NEUROCHEMISTRY

Cellular Membrane Fluidity in Amyloid Precursor Protein Processing

(2014) Xiaoguang Yang et al.   MOLECULAR NEUROBIOLOGY

ATP-binding cassette transporter A1: From metabolism to neurodegeneration

(2014) Radosveta Koldamova et al.   NEUROBIOLOGY OF DISEASE

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

(2013) Clifford R Jack et al.   LANCET NEUROLOGY

Peroxisome Proliferator-Activated Receptor Targets for the Treatment of Metabolic Diseases

(2013) Francisco A. Monsalve et al.   MEDIATORS OF INFLAMMATION

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Role of ABC Transporters in the Pathogenesis of Alzheimer’s Disease

(2012) Alaa H. Abuznait et al.   ACS Chemical Neuroscience

Neuroprotective cyclopentenone prostaglandins up-regulate neurotrophic factors in C6 glioma cells

(2012) Yoko Hirata et al.   BRAIN RESEARCH

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model

(2012) Jose Morales-Corraliza et al.   NEUROBIOLOGY OF AGING

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

PPAR-γ Ligands Repress TGFβ-Induced Myofibroblast Differentiation by Targeting the PI3K/Akt Pathway: Implications for Therapy of Fibrosis

(2011) Ajit A. Kulkarni et al.   PLoS One

Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice

(2010) Tomoko Kurata et al.   BRAIN RESEARCH

Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β1–40 administration in mice: Evidence for dissociation between cognitive deficits and neuronal damage

(2010) Tetsadê C.B. Piermartiri et al.   EXPERIMENTAL NEUROLOGY

Modulation of ABCA1 by an LXR Agonist Reduces Beta-Amyloid Levels and Improves Outcome after Traumatic Brain Injury

(2010) David J. Loane et al.   JOURNAL OF NEUROTRAUMA

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

A biotinylated analog of the anti-proliferative prostaglandin A1 allows assessment of PPAR-independent effects and identification of novel cellular targets for covalent modification

(2009) Beatriz Garzón et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) Ligands: Novel Pharmacological Agents in the Treatment of Ischemia Reperfusion Injury

(2008) Costas Giaginis et al.   CURRENT MOLECULAR MEDICINE

High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice

(2008) Lakshmi Thirumangalakudi et al.   JOURNAL OF NEUROCHEMISTRY

ACAT as a Drug Target for Alzheimer’s Disease

(2008) Henri J. Huttunen et al.   Neurodegenerative Diseases

PPARγ agonists as therapeutics for the treatment of Alzheimer’s disease

(2008) Gary Landreth et al.   Neurotherapeutics

Targeting β-amyloid pathology in Alzheimer’s disease with Aβ immunotherapy

(2008) Roger M. Nitsch et al.   Neurotherapeutics

Neuroprotective effects of prostaglandin A1 in rat models of permanent focal cerebral ischemia are associated with nuclear factor-κB inhibition and peroxisome proliferator-activated receptor-γ up-regulation

(2007) Hui-Ling Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cholesterol retention in Alzheimer's brain is responsible for high β- and γ-secretase activities and Aβ production

(2007) Huaqi Xiong et al.   NEUROBIOLOGY OF DISEASE