An influenza H1 hemagglutinin stem-only immunogen elicits a broadly cross-reactive B cell response in humans

Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial

(2022) Katherine V. Houser et al.   NATURE MEDICINE

A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination

(2022) Sarah F. Andrews et al.   NATURE MEDICINE

Elicitation of pneumovirus-specific B cell responses by a prefusion-stabilized respiratory syncytial virus F subunit vaccine

(2022) Emily Phung et al.   Science Translational Medicine

Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination

(2021) Julianna Han et al.   Cell Reports

A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

(2021) Adrian Creanga et al.   Nature Communications

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

(2021) Jenna J. Guthmiller et al.   NATURE

Next-Generation Influenza Vaccines

(2020) Masaru Kanekiyo et al.   Cold Spring Harbor Perspectives in Medicine

Improvement of cryo-EM maps by density modification

(2020) Thomas C. Terwilliger et al.   NATURE METHODS

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

(2020) Raffael Nachbagauer et al.   NATURE MEDICINE

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

(2019) Kizzmekia S. Corbett et al.   mBio

Assessing the protective potential of H1N1 influenza virus hemagglutinin head and stalk antibodies in humans

(2019) Shannon R. Christensen et al.   JOURNAL OF VIROLOGY

Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin

(2019) Sarah F. Andrews et al.   IMMUNITY

Novel correlates of protection against pandemic H1N1 influenza A virus infection

(2019) Sophia Ng et al.   NATURE MEDICINE

Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial

(2019) David I Bernstein et al.   LANCET INFECTIOUS DISEASES

Pandemic influenza virus vaccines boost hemagglutinin stalk-specific antibody responses in primed adult and pediatric cohorts

(2019) Raffael Nachbagauer et al.   npj Vaccines

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

(2018) A Danielle Iuliano et al.   LANCET

Evaluation of Preexisting Anti-Hemagglutinin Stalk Antibody as a Correlate of Protection in a Healthy Volunteer Challenge with Influenza A/H1N1pdm Virus

(2018) Jae-Keun Park et al.   mBio

Influenza hemagglutinin membrane anchor

(2018) Donald J. Benton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination

(2018) Karlynn E. Neu et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of Broadly Cross-Reactive Stalk-Specific Antibody Responses to Influenza Group 1 and Group 2 Hemagglutinins by Natural H7N9 Virus Infection in Humans

(2017) Lu Liu et al.   JOURNAL OF INFECTIOUS DISEASES

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Is It Possible to Develop a “Universal” Influenza Virus Vaccine?

(2017) Sarah F. Andrews et al.   Cold Spring Harbor Perspectives in Biology

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

(2017) Raffael Nachbagauer et al.   npj Vaccines

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

(2016) M. Gordon Joyce et al.   CELL

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

(2016) Nicole L. Kallewaard et al.   CELL

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity

(2016) Yuval Avnir et al.   Scientific Reports

Stalking influenza by vaccination with pre-fusion headless HA mini-stem

(2016) Sophie A. Valkenburg et al.   Scientific Reports

Change-O: a toolkit for analyzing large-scale B cell immunoglobulin repertoire sequencing data: Table 1.

(2015) Namita T. Gupta et al.   BIOINFORMATICS

H5N1 Vaccine–Elicited Memory B Cells Are Genetically Constrained by the IGHV Locus in the Recognition of a Neutralizing Epitope in the Hemagglutinin Stem

(2015) Adam K. Wheatley et al.   JOURNAL OF IMMUNOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Design and Structure of an Engineered Disulfide-Stabilized Influenza Virus Hemagglutinin Trimer

(2015) Peter S. Lee et al.   JOURNAL OF VIROLOGY

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

(2015) Nicole A. Doria-Rose et al.   JOURNAL OF VIROLOGY

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

Restricted, canonical, stereotyped and convergent immunoglobulin responses

(2015) Carole J. Henry Dunand et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

Immune history profoundly affects broadly protective B cell responses to influenza

(2015) Sarah F. Andrews et al.   Science Translational Medicine

Longitudinal analysis of the peripheral B cell repertoire reveals unique effects of immunization with a new influenza virus strain

(2015) Bernardo Cortina-Ceballos et al.   Genome Medicine

Hemagglutinin Sequence Conservation Guided Stem Immunogen Design from Influenza A H3 Subtype

(2015) V. Vamsee Aditya Mallajosyula et al.   Frontiers in Immunology

Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages

(2014) J. R. R. Whittle et al.   JOURNAL OF VIROLOGY

Rapid development of broadly influenza neutralizing antibodies through redundant mutations

(2014) Leontios Pappas et al.   NATURE

Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans

(2014) A. H. Ellebedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prime-Boost Interval Matters: A Randomized Phase 1 Study to Identify the Minimum Interval Necessary to Observe the H5 DNA Influenza Vaccine Priming Effect

(2013) Julie E. Ledgerwood, Kathryn Zephir, Zonghui Hu, Chih-Jen Wei, LeeJah Chang, Mary E. Enama, Cynthia S. Hendel, Sandra Sitar, Robert T. Bailer, Richard A. Koup, John R. Mascola, Gary J. Nabel, Barney S. Graham et al.   JOURNAL OF INFECTIOUS DISEASES

H3 Stalk-Based Chimeric Hemagglutinin Influenza Virus Constructs Protect Mice from H7N9 Challenge

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

(2013) Masaru Kanekiyo et al.   NATURE

1976 and 2009 H1N1 Influenza Virus Vaccines Boost Anti-Hemagglutinin Stalk Antibodies in Humans

(2012) Matthew S. Miller et al.   JOURNAL OF INFECTIOUS DISEASES

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Structural and genetic basis for development of broadly neutralizing influenza antibodies

(2012) Daniel Lingwood et al.   NATURE

Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells

(2012) G.-M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Pandemic H1N1 Influenza Infection and Vaccination in Humans Induces Cross-Protective Antibodies that Target the Hemagglutinin Stem

(2012) C. A. Thomson et al.   Frontiers in Immunology

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

(2011) Jens Wrammert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials

(2011) Julie E Ledgerwood et al.   LANCET INFECTIOUS DISEASES

Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination

(2010) C.-J. Wei et al.   SCIENCE

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Circos: An information aesthetic for comparative genomics

(2009) M. Krzywinski et al.   GENOME RESEARCH

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

DoG Picker and TiltPicker: Software tools to facilitate particle selection in single particle electron microscopy

(2009) N.R. Voss et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Blood-borne human plasma cells in steady state are derived from mucosal immune responses

(2008) H. E. Mei et al.   BLOOD

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis

(2008) X. Brochet et al.   NUCLEIC ACIDS RESEARCH

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS