Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

(2022) Krishna G. Aragam et al.   NATURE GENETICS

Pulmonary Manifestations of Immune Dysregulation in CTLA‐4 Haploinsufficiency and LRBA Deficiency

(2021) Katie A. Krone et al.   PEDIATRIC PULMONOLOGY

Chromatin Landscapes of Human Lung Cells Predict Potentially Functional COPD GWAS Variants

(2021) Christopher J Benway et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A large-scale genome-wide association analysis of lung function in the Chinese population identifies novel loci and highlights shared genetic etiology with obesity

(2021) Zhaozhong Zhu et al.   EUROPEAN RESPIRATORY JOURNAL

Methodology in phenome-wide association studies: a systematic review

(2021) Lijuan Wang et al.   JOURNAL OF MEDICAL GENETICS

Rare variant contribution to human disease in 281,104 UK Biobank exomes

(2021) Quanli Wang et al.   NATURE

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

(2021) Urmo Võsa et al.   NATURE GENETICS

Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses

(2021) Alison R. Barton et al.   NATURE GENETICS

Improving ethnic diversity in respiratory genomics research

(2021) Martin D. Tobin et al.   EUROPEAN RESPIRATORY JOURNAL

Exome sequencing and analysis of 454,787 UK Biobank participants

(2021) Joshua D. Backman et al.   NATURE

A more accurate method for colocalisation analysis allowing for multiple causal variants

(2021) Chris Wallace   PLoS Genetics

Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2020) Joan B Soriano et al.   Lancet Respiratory Medicine

Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data across 27 Tissue Types

(2020) Cory C. Funk et al.   Cell Reports

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

(2019) Nick Shrine et al.   NATURE GENETICS

GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals

(2019) Valentina Iotchkova et al.   NATURE GENETICS

The Missing Diversity in Human Genetic Studies

(2019) Giorgio Sirugo et al.   CELL

FGF10-FGFR2B Signaling Generates Basal Cells and Drives Alveolar Epithelial Regeneration by Bronchial Epithelial Stem Cells after Lung Injury

(2019) Tingting Yuan et al.   Stem Cell Reports

A Bayesian framework for multiple trait colocalization from summary association statistics

(2018) Claudia Giambartolomei et al.   BIOINFORMATICS

Respiratory manifestations in LPS-responsive beige-like anchor (LRBA) protein-deficient patients

(2018) Oded Shamriz et al.   EUROPEAN JOURNAL OF PEDIATRICS

Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry

(2018) Loic Yengo et al.   HUMAN MOLECULAR GENETICS

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

(2018) Annah B. Wyss et al.   Nature Communications

Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA

(2018) Julius Gudmundsson et al.   Nature Communications

Genome-wide association meta-analysis yields 20 loci associated with gallstone disease

(2018) Egil Ferkingstad et al.   Nature Communications

Characterization of zolbetuximab in pancreatic cancer models

(2018) Ӧzlem Türeci et al.   OncoImmunology

Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution

(2017) Reedik Mägi et al.   HUMAN MOLECULAR GENETICS

Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma

(2017) Kelly Sweerus et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

(2017) Louise V Wain et al.   NATURE GENETICS

Hypogonadotropic Hypogonadism due to Novel FGFR1 Mutations

(2017) Gamze Akkuş et al.   Journal of Clinical Research in Pediatric Endocrinology

Resetting the bar: Statistical significance in whole-genome sequencing-based association studies of global populations

(2016) Sara L. Pulit et al.   GENETIC EPIDEMIOLOGY

Analyzing and interpreting genome data at the network level with ConsensusPathDB

(2016) Ralf Herwig et al.   Nature Protocols

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

(2015) María Soler Artigas et al.   Nature Communications

Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits

(2014) Joseph K. Pickrell   AMERICAN JOURNAL OF HUMAN GENETICS

Claudin-18 Deficiency Results in Alveolar Barrier Dysfunction and Impaired Alveologenesis in Mice

(2014) Michael J. LaFemina et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis

(2014) Michael H Cho et al.   Lancet Respiratory Medicine

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

(2012) Ke Hao et al.   PLoS Genetics

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Fast model-based estimation of ancestry in unrelated individuals

(2009) D. H. Alexander et al.   GENOME RESEARCH

Genome-wide association study identifies five loci associated with lung function

(2009) Emmanouela Repapi et al.   NATURE GENETICS