Programmable protein delivery with a bacterial contractile injection system

Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases

(2022) Kayeong Lim et al.   Nature Communications

Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria

(2022) Gregor L. Weiss et al.   Nature Microbiology

Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis

(2022) Jingwei Xu et al.   Nature Microbiology

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system

(2022) Feng Jiang et al.   Science Advances

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Characterization of Photorhabdus Virulence Cassette as a causative agent in the emerging pathogen Photorhabdus asymbiotica

(2021) Xia Wang et al.   Science China-Life Sciences

The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins

(2021) Alexander Martin Geller et al.   Nature Communications

Action of a minimal contractile bactericidal nanomachine

(2020) Peng Ge et al.   NATURE

Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System

(2019) Feng Jiang et al.   CELL

A Bacterial Phage Tail-like Structure Kills Eukaryotic Cells by Injecting a Nuclease Effector

(2019) Iara Rocchi et al.   Cell Reports

A contractile injection system stimulates tubeworm metamorphosis by translocating a proteinaceous effector

(2019) Charles F Ericson et al.   eLife

The Photorhabdus asymbiotica virulence cassettes deliver protein effectors directly into target eukaryotic cells

(2019) Isabella Vlisidou et al.   eLife

Atomic structures of an entire contractile injection system in both the extended and contracted states

(2019) Ambroise Desfosses et al.   Nature Microbiology

Engineering Phage Host-Range and Suppressing Bacterial Resistance through Phage Tail Fiber Mutagenesis

(2019) Kevin Yehl et al.   CELL

How the phage T4 injection machinery works including energetics, forces, and dynamic pathway

(2019) Ameneh Maghsoodi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide Identification and Characterization of a Superfamily of Bacterial Extracellular Contractile Injection Systems

(2019) Lihong Chen et al.   Cell Reports

Reprogramming Bacteriophage Host Range through Structure-Guided Design of Chimeric Receptor Binding Proteins

(2019) Matthew Dunne et al.   Cell Reports

Molecular anatomy of the receptor binding module of a bacteriophage long tail fiber

(2019) Mohammad Z. Islam et al.   PLoS Pathogens

Protein-Injection Machines in Bacteria

(2018) Jorge E. Galán et al.   CELL

Contractile injection systems of bacteriophages and related systems

(2018) Nicholas M. I. Taylor et al.   MOLECULAR MICROBIOLOGY

A type VI secretion system effector delivery mechanism dependent on PAAR and a chaperone–co-chaperone complex

(2018) Brianne J. Burkinshaw et al.   Nature Microbiology

Molecular and Evolutionary Determinants of Bacteriophage Host Range

(2018) Patrick A. de Jonge et al.   TRENDS IN MICROBIOLOGY

In situ architecture, function, and evolution of a contractile injection system

(2017) Désirée Böck et al.   SCIENCE

Using Force to Punch Holes: Mechanics of Contractile Nanomachines

(2017) Maximilian Brackmann et al.   TRENDS IN CELL BIOLOGY

The Hcp proteins fused with diverse extended-toxin domains represent a novel pattern of antibacterial effectors in type VI secretion systems

(2017) Jiale Ma et al.   Virulence

Optimized Triton X-114 assisted lipopolysaccharide (LPS) removal method reveals the immunomodulatory effect of food proteins

(2017) Malgorzata Teodorowicz et al.   PLoS One

Structural remodeling of bacteriophage T4 and host membranes during infection initiation

(2015) Bo Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Noninvasive imaging of immune responses

(2015) Mohammad Rashidian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Modular Viral Scaffolds for Targeted Bacterial Population Editing

(2015) Hiroki Ando et al.   Cell Systems

A Phage Tail-Derived Element with Wide Distribution among Both Prokaryotic Domains: A Comparative Genomic and Phylogenetic Study

(2014) P. F. Sarris et al.   Genome Biology and Evolution

Marine Tubeworm Metamorphosis Induced by Arrays of Bacterial Phage Tail-Like Structures

(2014) N. J. Shikuma et al.   SCIENCE

Three-dimensional Structure of the Toxin-delivery Particle Antifeeding Prophage ofSerratia entomophila

(2013) J. Bernard Heymann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into Head-Tailed Viruses Infecting Extremely Halophilic Archaea

(2013) M. K. Pietila et al.   JOURNAL OF VIROLOGY

Type VI secretion requires a dynamic contractile phage tail-like structure

(2012) M. Basler et al.   NATURE

An Engineered R-Type Pyocin Is a Highly Specific and Sensitive Bactericidal Agent for the Food-Borne Pathogen Escherichia coli O157:H7

(2009) D. Scholl et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enterohemorrhagic Escherichia coli O157∶H7 Gene Expression Profiling in Response to Growth in the Presence of Host Epithelia

(2009) Narveen Jandu et al.   PLoS One

Efficient Selection of DARPins with Sub-nanomolar Affinities using SRP Phage Display

(2008) Daniel Steiner et al.   JOURNAL OF MOLECULAR BIOLOGY