N-terminal signal peptides facilitate the engineering of PVC complex as a potent protein delivery system

Type IV pilus retraction enables sustained bacteremia and plays a key role in the outcome of meningococcal sepsis in a humanized mouse model

(2021) Jean-Philippe Barnier et al.   PLoS Pathogens

Engineering a customizable antibacterial T6SS‐based platform in Vibrio natriegens

(2021) Biswanath Jana et al.   EMBO REPORTS

Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase

(2021) Steven J. Hersch et al.   mBio

The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis

(2021) Vincent Deruelle et al.   Nature Communications

The extracellular contractile injection system is enriched in environmental microbes and associates with numerous toxins

(2021) Alexander Martin Geller et al.   Nature Communications

Manipulating the type VI secretion system spike to shuttle passenger proteins

(2020) Sarah Wettstadt et al.   PLoS One

The Photorhabdus Virulence Cassettes RRSP-Like Effector Interacts With Cyclin-Dependent Kinase 1 and Causes Mitotic Defects in Mammalian Cells

(2020) Xia Wang et al.   Frontiers in Microbiology

Delivery of Heterologous Proteins, Enzymes, and Antigens via the Bacterial Type III Secretion System

(2020) Heather A. Pendergrass et al.   Microorganisms

Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

(2020) Shehryar Ahmad et al.   eLife

Redirecting Pore Assembly of Staphylococcal α-Hemolysin by Protein Engineering

(2019) Sunwoo Koo et al.   ACS Central Science

Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry

(2019) Dorothy D. Majewski et al.   Nature Communications

Cryo-EM Structure and Assembly of an Extracellular Contractile Injection System

(2019) Feng Jiang et al.   CELL

A Type VI Secretion System Trans-Kingdom Effector Is Required for the Delivery of a Novel Antibacterial Toxin in Pseudomonas aeruginosa

(2019) Benjamin Berni et al.   Frontiers in Microbiology

Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs

(2019) Tristan Bepler et al.   NATURE METHODS

Structure of a Tc holotoxin pore provides insights into the translocation mechanism

(2019) Daniel Roderer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards the application of Tc toxins as a universal protein translocation system

(2019) Daniel Roderer et al.   Nature Communications

Bacterial type III secretion system as a protein delivery tool for a broad range of biomedical applications

(2018) Fang Bai et al.   BIOTECHNOLOGY ADVANCES

A unique cytoplasmic ATPase complex defines the Legionella pneumophila type IV secretion channel

(2018) David Chetrit et al.   Nature Microbiology

A type VI secretion system effector delivery mechanism dependent on PAAR and a chaperone–co-chaperone complex

(2018) Brianne J. Burkinshaw et al.   Nature Microbiology

Tc toxin activation requires unfolding and refolding of a β-propeller

(2018) Christos Gatsogiannis et al.   NATURE

Structural and Functional Investigation and Pharmacological Mechanism of Trichosanthin, a Type 1 Ribosome-Inactivating Protein

(2018) Wei-Wei Shi et al.   Toxins

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Visualization of the type III secretion mediated Salmonella–host cell interface using cryo-electron tomography

(2018) Donghyun Park et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Structural insights into the roles of the IcmS–IcmW complex in the type IVb secretion system ofLegionella pneumophila

(2017) Jianpo Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CagA-mediated pathogenesis of Helicobacter pylori

(2016) Abolghasem Tohidpour   MICROBIAL PATHOGENESIS

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

(2016) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

VgrG C terminus confers the type VI effector transport specificity and is required for binding with PAAR and adaptor–effector complex

(2016) Devanand D. Bondage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type VI secretion system sheaths as nanoparticles for antigen display

(2016) Elena Del Tordello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type III Secretion: Building and Operating a Remarkable Nanomachine

(2016) Athina G. Portaliou et al.   TRENDS IN BIOCHEMICAL SCIENCES

An Interbacterial NAD(P)+ Glycohydrolase Toxin Requires Elongation Factor Tu for Delivery to Target Cells

(2015) John C. Whitney et al.   CELL

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Cas9-Assisted Targeting of CHromosome segments CATCH enables one-step targeted cloning of large gene clusters

(2015) Wenjun Jiang et al.   Nature Communications

Metalloprotease NleC Suppresses Host NF-κB/Inflammatory Responses by Cleaving p65 and Interfering with the p65/RPS3 Interaction

(2015) Andrea Hodgson et al.   PLoS Pathogens

Bacterial Type III Secretion Systems: Specialized Nanomachines for Protein Delivery into Target Cells

(2014) Jorge E. Galán et al.   Annual Review of Microbiology

A Pseudomonas aeruginosa Type VI Secretion Phospholipase D Effector Targets Both Prokaryotic and Eukaryotic Cells

(2014) Feng Jiang et al.   Cell Host & Microbe

Bacterial Delivery of Staphylococcus aureus α-Hemolysin Causes Regression and Necrosis in Murine Tumors

(2014) Adam T St. Jean et al.   MOLECULAR THERAPY

Mechanism of Tc toxin action revealed in molecular detail

(2014) Dominic Meusch et al.   NATURE

ClpV recycles VipA/VipB tubules and prevents non-productive tubule formation to ensure efficient type VI protein secretion

(2013) Nicole Kapitein et al.   MOLECULAR MICROBIOLOGY

Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors

(2013) Alistair B. Russell et al.   NATURE

Type III Secretion of ExoU Is Critical during Early Pseudomonas aeruginosa Pneumonia

(2013) H. A. Howell et al.   mBio

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Comparative genomics of the emerging human pathogen Photorhabdus asymbiotica with the insect pathogen Photorhabdus luminescens

(2009) Paul Wilkinson et al.   BMC GENOMICS

Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation

(2009) Masato Suzuki et al.   Cell Host & Microbe

Potential role for ESAT6 in dissemination ofM. tuberculosisvia human lung epithelial cells

(2009) Arvind G. Kinhikar et al.   MOLECULAR MICROBIOLOGY