Chemical Genetic Identification of PKC Epsilon Substrates in Mouse Brain

MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome

(2021) Cedric Thues et al.   Scientific Reports

Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

(2021) Manav Kapoor et al.   Nature Communications

Single cell transcriptome profiling of the human alcohol-dependent brain

(2020) Eric Brenner et al.   HUMAN MOLECULAR GENETICS

Reconstructing kinase network topologies from phosphoproteomics data reveals cancer-associated rewiring

(2020) Maruan Hijazi et al.   NATURE BIOTECHNOLOGY

Intersectin-Mediated Clearance of SNARE Complexes Is Required for Fast Neurotransmission

(2020) Maria Jäpel et al.   Cell Reports

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

(2020) Bin Peng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A multi‐omic analysis of the dorsal striatum in an animal model of divergent genetic risk for alcohol use disorder

(2020) Gregory G. Grecco et al.   JOURNAL OF NEUROCHEMISTRY

UniProt: the universal protein knowledgebase in 2021

(2020) et al.   NUCLEIC ACIDS RESEARCH

Hidden proteome of synaptic vesicles in the mammalian brain

(2020) Zacharie Taoufiq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A gene expression atlas for different kinds of stress in the mouse brain

(2020) Tiziano Flati et al.   Scientific Data

MAPT mutations, tauopathy, and mechanisms of neurodegeneration

(2019) Kevin H. Strang et al.   LABORATORY INVESTIGATION

Proteomics Reveals Profound Metabolic Changes in the Alcohol Use Disorder Brain

(2019) Charmaine Enculescu et al.   ACS Chemical Neuroscience

Homozygous variants in MAPRE2 and CDON in individual with skin folds, growth delay, retinal coloboma, and pyloric stenosis

(2019) Lina Berkun et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Synapsin I Synchronizes GABA Release in Distinct Interneuron Subpopulations

(2019) N Forte et al.   CEREBRAL CORTEX

Multi-omics analysis identifies mitochondrial pathways associated with anxiety-related behavior

(2019) Zuzanna Misiewicz et al.   PLoS Genetics

Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins

(2019) Norbert Bencsik et al.   Scientific Reports

Novel Small-Molecule Inhibitors of Protein Kinase C Epsilon Reduce Ethanol Consumption in Mice

(2018) Angelo Blasio et al.   BIOLOGICAL PSYCHIATRY

Tubulin genes and malformations of cortical development

(2018) Romina Romaniello et al.   European Journal of Medical Genetics

Mining the nucleus accumbens proteome for novel targets of alcohol self-administration in male C57BL/6J mice

(2018) Sara Faccidomo et al.   PSYCHOPHARMACOLOGY

Dissecting Brain Networks Underlying Alcohol Binge Drinking Using a Systems Genomics Approach

(2018) Laura B. Ferguson et al.   MOLECULAR NEUROBIOLOGY

PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling

(2018) Brandon M. Gassaway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5

(2018) Thomas B. Schaffer et al.   Cell Reports

Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery

(2018) Tayo Katano et al.   Molecular Brain

Neuroimmune signaling in alcohol use disorder

(2018) Emma K. Erickson et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Genome-Wide Expression Profiles Drive Discovery of Novel Compounds that Reduce Binge Drinking in Mice

(2017) Laura B Ferguson et al.   NEUROPSYCHOPHARMACOLOGY

Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus

(2017) Burkhard Jakob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intersectin associates with synapsin and regulates its nanoscale localization and function

(2017) Fabian Gerth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α, β-DCP-LA Selectively Activates PKC-ε and Stimulates Neurotransmitter Release with the Highest Potency among 4 Diastereomers

(2017) Tadashi Shimizu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Protein Kinase Cϵ (PKCϵ) Promotes Synaptogenesis through Membrane Accumulation of the Postsynaptic Density Protein PSD-95

(2016) Abhik Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type

(2015) Mala Isrie et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy

(2015) Cheng-Cheng Zhang et al.   MOLECULAR NEUROBIOLOGY

Defeat stress in rodents: From behavior to molecules

(2015) Caroline Hammels et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release

(2015) Teresa Obis et al.   Molecular Brain

Chronic Ethanol Exposure Produces Time- and Brain Region-Dependent Changes in Gene Coexpression Networks

(2015) Elizabeth A. Osterndorff-Kahanek et al.   PLoS One

MS-Viewer: A Web-based Spectral Viewer for Proteomics Results

(2014) Peter R. Baker et al.   MOLECULAR & CELLULAR PROTEOMICS

GeneFriends: a human RNA-seq-based gene and transcript co-expression database

(2014) Sipko van Dam et al.   NUCLEIC ACIDS RESEARCH

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

“Drinking in the dark” (DID) procedures: A model of binge-like ethanol drinking in non-dependent mice

(2013) Todd E. Thiele et al.   ALCOHOL

Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways

(2013) Michael Hunter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gene Expression in Brain and Liver Produced by Three Different Regimens of Alcohol Consumption in Mice: Comparison with Immune Activation

(2013) Elizabeth Osterndorff-Kahanek et al.   PLoS One

Fast neurotransmitter release regulated by the endocytic scaffold intersectin

(2013) T. Sakaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GeneFriends: An online co-expression analysis tool to identify novel gene targets for aging and complex diseases

(2012) Sipko van Dam et al.   BMC GENOMICS

Gene Coexpression Networks in Human Brain Identify Epigenetic Modifications in Alcohol Dependence

(2012) I. Ponomarev et al.   JOURNAL OF NEUROSCIENCE

Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development

(2012) Sila K. Ultanir et al.   NEURON

Molecular Profiles of Drinking Alcohol to Intoxication in C57BL/6J Mice

(2011) Megan K. Mulligan et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men

(2011) Inkyung Baik et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases

(2011) Yuan Chen et al.   Frontiers of Medicine

Genome-Wide Association Study of Alcohol Dependence Implicates a Region on Chromosome 11

(2010) Howard J. Edenberg et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

A proteomic analysis of PKCε targets in astrocytes: implications for astrogliosis

(2010) Miguel Burgos et al.   AMINO ACIDS

The substrates and binding partners of protein kinase Cε

(2010) Philip M. Newton et al.   BIOCHEMICAL JOURNAL

Intersectin 1: a versatile actor in the synaptic vesicle cycle

(2010) Arndt Pechstein et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

Intersectin Regulates Dendritic Spine Development and Somatodendritic Endocytosis but Not Synaptic Vesicle Recycling in Hippocampal Neurons

(2009) Sébastien Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenylyl Cyclases 1 and 8 Initiate a Presynaptic Homeostatic Response to Ethanol Treatment

(2009) Alana C. Conti et al.   PLoS One

A Line of Mice Selected for High Blood Ethanol Concentrations Shows Drinking in the Dark to Intoxication

(2008) John C. Crabbe et al.   BIOLOGICAL PSYCHIATRY

Protein kinase Cε: multiple roles in the function of, and signaling mediated by, the cytoskeleton

(2008) Yoshiko Akita   FEBS Journal

Protein kinase Cε: function in neurons

(2008) Yasuhito Shirai et al.   FEBS Journal

Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates

(2008) J. D. Blethrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala

(2008) M. Bajo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amygdala protein kinase C epsilon regulates corticotropin-releasing factor and anxiety-like behavior

(2007) H. M. B. Lesscher et al.   GENES BRAIN AND BEHAVIOR