MAPT mutations, tauopathy, and mechanisms of neurodegeneration

Prion-like Spreading in Tauopathies

(2018) Jacob I. Ayers et al.   BIOLOGICAL PSYCHIATRY

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain

(2018) Sarah L. DeVos et al.   Frontiers in Neuroscience

Clinical, Neuropathological, and Biochemical Characterization of the Novel Tau Mutation P332S

(2018) Vincent Deramecourt et al.   JOURNAL OF ALZHEIMERS DISEASE

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

(2017) Kevin H. Strang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils

(2017) Garrett S. Gibbons et al.   JOURNAL OF NEUROSCIENCE

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue

(2017) Sarah K. Kaufman et al.   Acta Neuropathologica Communications

Widespread tau seeding activity at early Braak stages

(2016) Jennifer L. Furman et al.   ACTA NEUROPATHOLOGICA

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

(2016) Bruno Vasconcelos et al.   ACTA NEUROPATHOLOGICA

High–Molecular-Weight Paired Helical Filaments from Alzheimer Brain Induces Seeding of Wild-Type Mouse Tau into an Argyrophilic 4R Tau Pathology in Vivo

(2016) Emilie Audouard et al.   AMERICAN JOURNAL OF PATHOLOGY

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

FTDP-17 with Pick body-like inclusions associated with a novel tau mutation, p.E372G

(2016) Pawel Tacik et al.   BRAIN PATHOLOGY

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

(2016) Chang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

(2016) S. J. Jackson et al.   JOURNAL OF NEUROSCIENCE

Tau Oligomers Derived from Traumatic Brain Injury Cause Cognitive Impairment and Accelerate Onset of Pathology in Htau Mice

(2016) Julia Gerson et al.   JOURNAL OF NEUROTRAUMA

Primary Fibril Nucleation of Aggregation Prone Tau Fragments PHF6 and PHF6*

(2016) Florent X. Smit et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells

(2016) Amanda L. Woerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau Structures

(2016) Jesus Avila et al.   Frontiers in Aging Neuroscience

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

(2016) M. Catarina Silva et al.   Stem Cell Reports

Using Human iPSC-Derived Neurons to Model TAU Aggregation

(2016) An Verheyen et al.   PLoS One

Inefficient induction and spread of seeded tau pathology in P301L mouse model of tauopathy suggests inherent physiological barriers to transmission

(2015) Paramita Chakrabarty et al.   ACTA NEUROPATHOLOGICA

A novel tau mutation, p.K317N, causes globular glial tauopathy

(2015) Pawel Tacik et al.   ACTA NEUROPATHOLOGICA

Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC’s afferent and efferent connections

(2015) Michiyo Iba et al.   ACTA NEUROPATHOLOGICA

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice

(2015) Ilie-Cosmin Stancu et al.   ACTA NEUROPATHOLOGICA

RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth

(2015) Paul D. Dinkel et al.   BIOCHEMISTRY

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

(2015) Hilda Mirbaha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Tau Mutation in Exon 12, p.Q336H, Causes Hereditary Pick Disease

(2015) Pawel Tacik et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Tau Assembly: The Dominant Role of PHF6 (VQIVYK) in Microtubule Binding Region Repeat R3

(2015) Pritam Ganguly et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Regulation of human MAPT gene expression

(2015) Marie-Laure Caillet-Boudin et al.   Molecular Neurodegeneration

Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells

(2015) Melissa C. Wren et al.   Molecular Neurodegeneration

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

(2015) Asami Kondo et al.   NATURE

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

(2015) Sang-Won Min et al.   NATURE MEDICINE

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

(2015) Eve Peeraer et al.   NEUROBIOLOGY OF DISEASE

Invited review: Frontotemporal dementia caused bymicrotubule-associated protein taugene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

(2015) Bernardino Ghetti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy

(2015) Naomi Kouri et al.   Nature Communications

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

(2015) Sarah L. Shammas et al.   Nature Communications

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

(2015) Maxime Derisbourg et al.   Scientific Reports

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brains

(2014) Susana Boluda et al.   ACTA NEUROPATHOLOGICA

Tau protein mutation P364S in two sisters: clinical course and neuropathology with emphasis on new, composite neuronal tau inclusions

(2014) Mara Popović et al.   ACTA NEUROPATHOLOGICA

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

(2014) Kristen E. Funk et al.   BIOCHEMICAL JOURNAL

Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates

(2014) Benjamin Falcon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau mutants bind tubulin heterodimers with enhanced affinity

(2014) S. Elbaum-Garfinkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of alternative splicing of tau exon 10

(2014) Wei Qian et al.   Neuroscience Bulletin

The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons

(2013) Mariangela Iovino et al.   ACTA NEUROPATHOLOGICA

Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice

(2013) Florence Clavaguera et al.   ACTA NEUROPATHOLOGICA

Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration

(2013) Naomi Kouri et al.   ACTA NEUROPATHOLOGICA

Acetylated Tau Neuropathology in Sporadic and Hereditary Tauopathies

(2013) David J. Irwin et al.   AMERICAN JOURNAL OF PATHOLOGY

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau

(2013) Jing L. Guo et al.   FEBS LETTERS

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Variation in tau isoform expression in different brain regions and disease states

(2013) Elisa Majounie et al.   NEUROBIOLOGY OF AGING

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

(2013) T. Kimura et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Novel MAPT Mutation, G55R, in a Frontotemporal Dementia Patient Leads to Altered Tau Function

(2013) Abhinaya Iyer et al.   PLoS One

Profiling Murine Tau with 0N, 1N and 2N Isoform-Specific Antibodies in Brain and Peripheral Organs Reveals Distinct Subcellular Localization, with the 1N Isoform Being Enriched in the Nucleus

(2013) Chang Liu et al.   PLoS One

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau alternative splicing in familial and sporadic tauopathies

(2012) Michael Niblock et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

FTDP-17 Tau Mutations Induce Distinct Effects on Aggregation and Microtubule Interactions

(2012) Benjamin Combs et al.   BIOCHEMISTRY

MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies

(2012) Daniah Trabzuni et al.   HUMAN MOLECULAR GENETICS

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases

(2012) Giovanni Coppola et al.   HUMAN MOLECULAR GENETICS

Tau Oligomers Impair Artificial Membrane Integrity and Cellular Viability

(2012) Katharina Flach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paired Helical Filaments from Alzheimer Disease Brain Induce Intracellular Accumulation of Tau Protein in Aggresomes

(2012) Ismael Santa-Maria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Basis for Asymmetric Seeding Barrier in Filaments of Three- and Four-Repeat Tau

(2012) Ayisha Siddiqua et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features

(2012) Eleanna Kara et al.   NEUROBIOLOGY OF AGING

Analyses of the MAPT, PGRN, and C9orf72 mutations in Japanese patients with FTLD, PSP, and CBS

(2012) Kotaro Ogaki et al.   PARKINSONISM & RELATED DISORDERS

Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles

(2011) Jing L. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Induction of Intracellular Tau Aggregation Is Promoted by  -Synuclein Seeds and Provides Novel Insights into the Hyperphosphorylation of Tau

(2011) E. A. Waxman et al.   JOURNAL OF NEUROSCIENCE

New mutations in MAPT gene causing frontotemporal lobar degeneration: biochemical and structural characterization

(2011) Giacomina Rossi et al.   NEUROBIOLOGY OF AGING

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Familial early onset frontotemporal dementia caused by a novel S356T MAPT mutation, initially diagnosed as schizophrenia

(2010) Parastoo Momeni et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Seeded Aggregation and Toxicity of α-Synuclein and Tau

(2010) Takashi Nonaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Three Repeat Isoforms of Tau Inhibit Assembly of Four Repeat Tau Filaments

(2010) Stephanie J. Adams et al.   PLoS One

Essential role of tau phosphorylation in adult hippocampal neurogenesis

(2009) Xiao-Ping Hong et al.   HIPPOCAMPUS

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

(2009) Will Stoothoff et al.   JOURNAL OF NEUROCHEMISTRY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

(2009) Marco D Mukrasch et al.   PLOS BIOLOGY

Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

(2008) Sadasivam Jeganathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

(2008) T. L. Spires-Jones et al.   JOURNAL OF NEUROSCIENCE

Tau exon 10 alternative splicing and tauopathies

(2008) Fei Liu et al.   Molecular Neurodegeneration