Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

Interpretation of risk loci from genome-wide association studies of Alzheimer's disease

(2020) Shea J Andrews et al.   LANCET NEUROLOGY

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

(2020) Hang Zhou et al.   NATURE NEUROSCIENCE

Abnormal expression of colony stimulating factor 1 receptor (CSF1R) and transcription factor PU.1 (SPI1) in the spleen from patients with major psychiatric disorders: A role of brain–spleen axis

(2020) Jiancheng Zhang et al.   JOURNAL OF AFFECTIVE DISORDERS

Targeting tau: Clinical trials and novel therapeutic approaches

(2020) Lawren VandeVrede et al.   NEUROSCIENCE LETTERS

Daily alcohol intake triggers aberrant synaptic pruning leading to synapse loss and anxiety-like behavior

(2020) Renato Socodato et al.   Science Signaling

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

(2019) Manav Kapoor et al.   Translational Psychiatry

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

(2019) Laura M. Huckins et al.   NATURE GENETICS

Genome‐wide association studies of alcohol dependence, DSM‐IV criterion count, and individual criteria

(2019) Dongbing Lai et al.   GENES BRAIN AND BEHAVIOR

Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations

(2019) Henry R. Kranzler et al.   Nature Communications

Convergent evidence for predispositional effects of brain gray matter volume on alcohol consumption

(2019) David AA. Baranger et al.   BIOLOGICAL PSYCHIATRY

Brain cell type–specific enhancer–promoter interactome maps and disease-risk association

(2019) Alexi Nott et al.   SCIENCE

Integration of summary data from GWAS and eQTL studies identified novel causal BMD genes with functional predictions

(2018) Xiang-He Meng et al.   BONE

Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

(2018) Ting Qi et al.   Nature Communications

A multi-omic atlas of the human frontal cortex for aging and Alzheimer’s disease research

(2018) Philip L. De Jager et al.   Scientific Data

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

(2018) Raymond K. Walters et al.   NATURE NEUROSCIENCE

A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease

(2017) Kuan-lin Huang et al.   NATURE NEUROSCIENCE

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

(2017) Bernard Ng et al.   NATURE NEUROSCIENCE

Neural basis of reward anticipation and its genetic determinants

(2016) Tianye Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

(2015) Muktha S. Natrajan et al.   BRAIN

Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locus

(2015) R S Desikan et al.   MOLECULAR PSYCHIATRY

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

(2015) Andrew E Jaffe et al.   NATURE NEUROSCIENCE

Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci

(2015) Eilis Hannon et al.   NATURE NEUROSCIENCE

Epidemiology ofDSM-5Alcohol Use Disorder

(2015) Bridget F. Grant et al.   JAMA Psychiatry

Developing a Quantitative Measure of Alcohol Consumption for Genomic Studies on Prospective Cohorts

(2015) Arpana Agrawal et al.   Journal of Studies on Alcohol and Drugs

Transcriptome organization for chronic alcohol abuse in human brain

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Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

Stress–response pathways are altered in the hippocampus of chronic alcoholics

(2013) Jeanette N. McClintick et al.   ALCOHOL

The CRHR1 gene, trauma exposure, and alcoholism risk: a test of G × E effects

(2013) L. A. Ray et al.   GENES BRAIN AND BEHAVIOR

Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocaine and Morphine Action

(2013) D. Ferguson et al.   JOURNAL OF NEUROSCIENCE

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Improved whole-chromosome phasing for disease and population genetic studies

(2012) Olivier Delaneau et al.   NATURE METHODS

The Relationship Between Genetic Influences on Alcohol Dependence and on Patterns of Alcohol Consumption

(2010) Kenneth S. Kendler et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Amygdala Transcriptome and Cellular Mechanisms Underlying Stress-Enhanced Fear Learning in a Rat Model of Posttraumatic Stress Disorder

(2010) Igor Ponomarev et al.   NEUROPSYCHOPHARMACOLOGY

Alcohol Consumption Indices of Genetic Risk for Alcohol Dependence

(2009) Julia D. Grant et al.   BIOLOGICAL PSYCHIATRY

Peroxisome Proliferator-Activated Receptor and Retinoic X Receptor in Alcoholic Liver Disease

(2009) Tommaso Mello et al.   PPAR Research

Functional organization of the transcriptome in human brain

(2008) Michael C Oldham et al.   NATURE NEUROSCIENCE