Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo

Insights Into Ferroptosis, a Novel Target for the Therapy of Cancer

(2022) Hong-Tao Wang et al.   Frontiers in Oncology

The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2022) Kamari Weaver et al.   Biomedicines

Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer

(2021) Ali Ghoochani et al.   CANCER RESEARCH

Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162

(2021) Dieter Moosmayer et al.   Acta Crystallographica Section D-Structural Biology

Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

(2021) Alexander Beatty et al.   Nature Communications

Ferroptosis: Biochemistry and Biology in Cancers

(2021) Zhiyuan Shi et al.   Frontiers in Oncology

Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis

(2021) Shuo Ni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer

(2021) Congjun Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Everolimus accelerates Erastin and RSL3-induced ferroptosis in renal cell carcinoma

(2021) Wang Yangyun et al.   GENE

Structure–activity relationships of GPX4 inhibitor warheads

(2020) John K. Eaton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis

(2020) Nobuaki Takahashi et al.   MOLECULAR CELL

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

(2019) John K. Eaton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy

(2018) Hengrui Liu et al.   BIOCHEMISTRY

Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

(2018) Astrid Borchert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Highly diastereoselective crystallization-induced asymmetric transformation of 1,3-disubstituted-tetrahydro-β-carbolines in water

(2017) Tian-Zhuo Meng et al.   RSC Advances

Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy

(2016) Ayako Hoshi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death

(2014) H Schoeneberger et al.   ONCOGENE

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

(2011) Michel Weïwer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY