Structure–activity relationships of GPX4 inhibitor warheads

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

(2020) John K. Eaton et al.   Nature Chemical Biology

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

(2019) Naoya Shindo et al.   Nature Chemical Biology

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

(2019) John K. Eaton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

(2018) Astrid Borchert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress

(2018) Jennifer Tsoi et al.   CANCER CELL

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

(2018) William C. Stafford et al.   Science Translational Medicine

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Why Nature Chose Selenium

(2016) Hans J. Reich et al.   ACS Chemical Biology

Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity

(2016) Yong Qian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Selenol Fluorescent Probes: Design, Synthesis, Structural Determinants, and Biological Applications

(2015) Baoxin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prolonged and tunable residence time using reversible covalent kinase inhibitors

(2015) J Michael Bradshaw et al.   Nature Chemical Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

(2014) Mark E. Flanagan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

(2011) Michel Weïwer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Analysis and Functional Prediction of Reactive Cysteine Residues

(2011) Stefano M. Marino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Catalytic Site of Glutathione Peroxidases

(2008) Silvio C. E. Tosatto et al.   ANTIOXIDANTS & REDOX SIGNALING

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY