Nanodrug removes physical barrier to promote T-cell infiltration for enhanced cancer immunotherapy

Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation

(2022) Yingying Shen et al.   Nature Communications

Dual-Sensitive PEG-Sheddable Nanodrug Hierarchically Incorporating PD-L1 Antibody and Zinc Phthalocyanine for Improved Immuno-Photodynamic Therapy

(2021) Zhenwei Su et al.   ACS Applied Materials & Interfaces

Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy

(2021) Jinsheng Huang et al.   BIOMATERIALS

Macrophage Polarization States in the Tumor Microenvironment

(2021) Ava J. Boutilier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Codelivery of Anti‐PD‐1 Antibody and Paclitaxel with Matrix Metalloproteinase and pH Dual‐Sensitive Micelles for Enhanced Tumor Chemoimmunotherapy

(2020) Zhenwei Su et al.   Small

Dual pH-sensitive nanodrug blocks PD-1 immune checkpoint and uses T cells to deliver NF-κB inhibitor for antitumor immunotherapy

(2020) Zecong Xiao et al.   Science Advances

Biodegradable calcium phosphate nanoparticles for cancer therapy

(2020) Razieh Khalifehzadeh et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Concepts of extracellular matrix remodelling in tumour progression and metastasis

(2020) Juliane Winkler et al.   Nature Communications

Folic acid-modified Exosome-PH20 enhances the efficiency of therapy via modulation of the tumor microenvironment and directly inhibits tumor cell metastasis

(2020) Chunxiang Feng et al.   Bioactive Materials

Immunotherapy: breaching the barriers for cancer treatment

(2019) Victor G. Martinez et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2019) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103+ dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity

(2019) Yeonsun Hong et al.   Journal of Extracellular Vesicles

Differential characterization of hepatic tumors in MR imaging by burst-released Mn2+-ions from hollow manganese-silicate nanoparticles in the liver

(2019) Jin Goo Kim et al.   BIOMATERIALS

Regulation of Human Natural Killer Cell IFN-γ Production by MicroRNA-146a via Targeting the NF-κB Signaling Pathway

(2018) Hongwei Wang et al.   Frontiers in Immunology

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

(2018) William J. Sullivan et al.   CELL

Rheumatic immune-related adverse events from cancer immunotherapy

(2018) Leonard H. Calabrese et al.   Nature Reviews Rheumatology

Collagenase-Encapsulated pH-Responsive Nanoscale Coordination Polymers for Tumor Microenvironment Modulation and Enhanced Photodynamic Nanomedicine

(2018) Jingjing Liu et al.   ACS Applied Materials & Interfaces

Characterization of abscopal effects of intratumoral electroporation-mediated IL-12 gene therapy

(2018) Anandaroop Mukhopadhyay et al.   GENE THERAPY

Immune checkpoint blockade opens a new way to cancer immunotherapy

(2018) Sanam Sadreddini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity

(2017) Purnima Bhat et al.   Cell Death & Disease

Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer

(2016) S. R. Hingorani et al.   CLINICAL CANCER RESEARCH

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

(2016) Roy S Herbst et al.   LANCET

Interleukin-12 inhibits the hepatocellular carcinoma growth by inducing macrophage polarization to the M1-like phenotype through downregulation of Stat-3

(2016) Qin Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Facile Generation of Tumor-pH-Labile Linkage-Bridged Block Copolymers for Chemotherapeutic Delivery

(2015) Chun-Yang Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Breaching the Castle Walls: Hyaluronan Depletion as a Therapeutic Approach to Cancer Therapy

(2015) H. Michael Shepard   Frontiers in Oncology

Abrogation of TNFα Production during Cancer Immunotherapy Is Crucial for Suppressing Side Effects Due to the Systemic Expression of IL-12

(2014) Bibiana Barrios et al.   PLoS One

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

(2012) Hélène Salmon et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting the Tumor Microenvironment in Cancer: Why Hyaluronidase Deserves a Second Look

(2011) C. J. Whatcott et al.   Cancer Discovery

Water-Soluble MnO Nanocolloid for a Molecular T1 MR Imaging: A Facile One-Pot Synthesis, In vivo T1 MR Images, and Account for Relaxivities

(2010) Myung Ju Baek et al.   ACS Applied Materials & Interfaces

Delivery of Therapeutic Proteins

(2010) Dipak S. Pisal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Targeted Delivery of Protein Drugs by Nanocarriers

(2010) Roberto Solaro et al.   Materials

Extracellular matrix genes as hypoxia-inducible targets

(2009) Johanna Myllyharju et al.   CELL AND TISSUE RESEARCH

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

Phase II study of interleukin-12 for treatment of plateau phase multiple myeloma (E1A96): A trial of the Eastern Cooperative Oncology Group

(2009) Martha Q. Lacy et al.   LEUKEMIA RESEARCH