Folic acid-modified Exosome-PH20 enhances the efficiency of therapy via modulation of the tumor microenvironment and directly inhibits tumor cell metastasis

High Molecular Weight Hyaluronan Suppresses Macrophage M1 Polarization and Enhances IL-10 Production in PM2.5-Induced Lung Inflammation

(2019) Qiwen Shi et al.   MOLECULES

Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103+ dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity

(2019) Yeonsun Hong et al.   Journal of Extracellular Vesicles

Tumor microenvironment and breast cancer survival: combined effects of breast fat, M2 macrophages and hyaluronan create a dismal prognosis

(2019) Satu Tiainen et al.   BREAST CANCER RESEARCH AND TREATMENT

Highly enhanced cancer immunotherapy by combining nanovaccine with hyaluronidase

(2018) Xiuwen Guan et al.   BIOMATERIALS

Parallel Accumulation of Tumor Hyaluronan, Collagen and Other Drivers of Tumor Progression

(2018) Xiaoming Li et al.   CLINICAL CANCER RESEARCH

HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma

(2018) Sunil R. Hingorani et al.   JOURNAL OF CLINICAL ONCOLOGY

Activated hyaluronan metabolism in the tumor matrix — Causes and consequences

(2018) Markku I. Tammi et al.   MATRIX BIOLOGY

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

(2018) Christopher B. Rodell et al.   Nature Biomedical Engineering

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

(2018) William J. Sullivan et al.   CELL

4Mu decreases CD47 expression on hepatic cancer stem cells and primes a potent antitumor T-cell response induced by interleukin-12

(2018) Marcelo M. Rodríguez et al.   MOLECULAR THERAPY

Folic acid inhibits colorectal cancer cell migration

(2018) Pei-Ching Ting et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

(2018) Qian Chen et al.   Nature Nanotechnology

Plasma hyaluronic acid level as a prognostic and monitoring marker of metastatic breast cancer

(2016) Cike Peng et al.   INTERNATIONAL JOURNAL OF CANCER

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

(2016) Hua Gong et al.   NANO LETTERS

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression

(2016) M. J. Oudin et al.   Cancer Discovery

A novel role of breast cancer-derived hyaluronan on inducement of M2-like tumor-associated macrophages formation

(2016) Guoliang Zhang et al.   OncoImmunology

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

Group B Streptococcus Evades Host Immunity by Degrading Hyaluronan

(2015) Stacey L. Kolar et al.   Cell Host & Microbe

Inorganic Materials as Supports for Covalent Enzyme Immobilization: Methods and Mechanisms

(2014) Paolo Zucca et al.   MOLECULES

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

Low Molecular Weight Hyaluronan Activates Cytosolic Phospholipase A2α and Eicosanoid Production in Monocytes and Macrophages

(2013) Milena Sokolowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding

(2013) Tiina A. Jokela et al.   WOUND REPAIR AND REGENERATION

Folic acid inhibits endothelial cell migration through inhibiting the RhoA activity mediated by activating the folic acid receptor/cSrc/p190RhoGAP-signaling pathway

(2012) Tien-Chi Hou et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of Breast Cancer Metastases by a Novel Inhibitor of TGFβ Receptor 1

(2012) Yuanzhang Fang et al.   JNCI-Journal of the National Cancer Institute

Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) Slows Cancer Development but Increases Metastases in TRAMP Prostate Cancer Prone Mice

(2012) Yasmin Husaini et al.   PLoS One

Multistimuli Responsive Supramolecular Vesicles Based on the Recognition of p-Sulfonatocalixarene and its Controllable Release of Doxorubicin

(2011) Kui Wang et al.   ACS Nano

Hyaluronan as an Immune Regulator in Human Diseases

(2011) Dianhua Jiang et al.   PHYSIOLOGICAL REVIEWS

Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models

(2010) C. B. Thompson et al.   MOLECULAR CANCER THERAPEUTICS

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Hyaluronan in human tumors: Pathobiological and prognostic messages from cell-associated and stromal hyaluronan

(2008) Raija H. Tammi et al.   SEMINARS IN CANCER BIOLOGY