Breaching the Castle Walls: Hyaluronan Depletion as a Therapeutic Approach to Cancer Therapy

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

(2015) C. J. Whatcott et al.   CLINICAL CANCER RESEARCH

4-Methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis

(2015) Flavia Piccioni et al.   GLYCOBIOLOGY

Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumors

(2015) E. R. Manuel et al.   Cancer Immunology Research

4-Methylumbelliferone Treatment and Hyaluronan Inhibition as a Therapeutic Strategy in Inflammation, Autoimmunity, and Cancer

(2015) Nadine Nagy et al.   Frontiers in Immunology

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

(2015) Suniti Misra et al.   Frontiers in Immunology

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Incorporation of Pentraxin 3 into Hyaluronan Matrices Is Tightly Regulated and Promotes Matrix Cross-linking

(2014) Natalia S. Baranova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-Associated Hyaluronan Limits Efficacy of Monoclonal Antibody Therapy

(2014) N. C. Singha et al.   MOLECULAR CANCER THERAPEUTICS

The Motile Breast Cancer Phenotype Roles of Proteoglycans/Glycosaminoglycans

(2014) Dragana Nikitovic et al.   Biomed Research International

Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment

(2014) Anne Kultti et al.   Biomed Research International

Hyaluronan: A simple polysaccharide with diverse biological functions

(2013) Kevin T. Dicker et al.   Acta Biomaterialia

The effect of desulfation of chondroitin sulfate on interactions with positively charged growth factors and upregulation of cartilaginous markers in encapsulated MSCs

(2013) Jeremy J. Lim et al.   BIOMATERIALS

Clinical impact of pentraxin family expression on prognosis of pancreatic carcinoma

(2013) S Kondo et al.   BRITISH JOURNAL OF CANCER

Tumor glycolysis as a target for cancer therapy: progress and prospects

(2013) Shanmugasundaram Ganapathy-Kanniappan et al.   Molecular Cancer

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Increased hyaluronan content and stromal cell CD44 associate withHER2positivity and poor prognosis in human breast cancer

(2012) Päivi Auvinen et al.   INTERNATIONAL JOURNAL OF CANCER

Binding of Trastuzumab to ErbB2 Is Inhibited by a High Pericellular Density of Hyaluronan

(2012) Tímea Váradi et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

Therapeutic Targeting of Hyaluronan in the Tumor Stroma

(2012) Anne Kultti et al.   Cancers

Abstract 58: Hyaluronan metabolism enhances the Warburg effect and provides an alternate energy source in the breast cancer microenvironment

(2011) Natalie K. Thomas et al.   CANCER RESEARCH

Aging Fibroblasts Resist Phenotypic Maturation Because of Impaired Hyaluronan-Dependent CD44/Epidermal Growth Factor Receptor Signaling

(2010) Russell M.L. Simpson et al.   AMERICAN JOURNAL OF PATHOLOGY

RHAMM is differentially expressed in the cell cycle and downregulated by the tumor suppressor p53

(2010) Sindy Sohr et al.   CELL CYCLE

Hyaluronan in human malignancies

(2010) R.K. Sironen et al.   EXPERIMENTAL CELL RESEARCH

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

(2010) Achilleas D. Theocharis et al.   FEBS Journal

Methyl-β-cyclodextrin Suppresses Hyaluronan Synthesis by Down-regulation of Hyaluronan Synthase 2 through Inhibition of Akt

(2010) Anne Kultti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proinflammatory Cytokines Induce Hyaluronan Synthesis and Monocyte Adhesion in Human Endothelial Cells through Hyaluronan Synthase 2 (HAS2) and the Nuclear Factor-κB (NF-κB) Pathway

(2010) Davide Vigetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models

(2010) C. B. Thompson et al.   MOLECULAR CANCER THERAPEUTICS

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities

(2009) B. P. Toole   CLINICAL CANCER RESEARCH

Inhibition of Functional Hyaluronan-CD44 Interactions in CD133-positive Primary Human Ovarian Carcinoma Cells by Small Hyaluronan Oligosaccharides

(2009) M. G. Slomiany et al.   CLINICAL CANCER RESEARCH

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK–ERK linkage

(2009) P P Provenzano et al.   ONCOGENE

Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression

(2008) Samuel Godar et al.   CELL

Hyaluronidases in cancer biology

(2008) Robert Stern   SEMINARS IN CANCER BIOLOGY

Hyaluronan in human tumors: Pathobiological and prognostic messages from cell-associated and stromal hyaluronan

(2008) Raija H. Tammi et al.   SEMINARS IN CANCER BIOLOGY