VBP1 negatively regulates CHIP and selectively inhibits the activity of hypoxia-inducible factor (HIF)-1α but not HIF-2α

TiPARP forms nuclear condensates to degrade HIF-1α and suppress tumorigenesis

(2020) Lu Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer

(2020) Sophie J. Cowman et al.   CLINICAL CANCER RESEARCH

VBP1 modulates Wnt/β-catenin signaling by mediating the stability of the transcription factors TCF/LEFs

(2020) Haifeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

(2020) Rouven Hoefflin et al.   Nature Communications

HIF1α is not a target of 14q deletion in clear cell renal cancer

(2020) Niraj Shenoy   Scientific Reports

HIF Inhibitors: Status of Current Clinical Development

(2019) Jaleh Fallah et al.   Current Oncology Reports

Hif-1α and Hif-2α regulate hemogenic endothelium and hematopoietic stem cell formation in zebrafish

(2018) Claudia Gerri et al.   BLOOD

Hypoxia-inducible factor stabilizers for treating anemia of chronic kidney disease

(2018) Sho Hasegawa et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

The ribosome biogenesis protein Esf1 is essential for pharyngeal cartilage formation in zebrafish

(2018) Jian-Yang Chen et al.   FEBS Journal

Inherent DNA‐binding specificities of the HIF‐1α and HIF‐2α transcription factors in chromatin

(2018) James A Smythies et al.   EMBO REPORTS

A compendium of proteins that interact with HIF-1α

(2017) Gregg L. Semenza   EXPERIMENTAL CELL RESEARCH

VBP1 represses cancer metastasis by enhancing HIF-1α degradation induced by pVHL

(2017) Ji Ae Kim et al.   FEBS Journal

A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis

(2016) Abdol-Hossein Rezaeian et al.   NATURE CELL BIOLOGY

pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation

(2015) Juan Du et al.   JOURNAL OF IMMUNOLOGY

CHIP is a novel tumor suppressor in pancreatic cancer and inhibits tumor growth through targeting EGFR

(2015) Tianxiao Wang et al.   Oncotarget

The role of HIF1α in renal cell carcinoma tumorigenesis

(2014) Lorraine J. Gudas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation

(2014) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia

(2014) Peng Zhang et al.   Cell Reports

VBP1 facilitates proteasome and autophagy-mediated degradation of MutS homologue hMSH4

(2013) Yang Xu et al.   FASEB JOURNAL

Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation

(2013) Maimon E. Hubbi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular, functional, and gene expression analysis of zebrafish hypoxia-inducible factor-3α

(2012) Peng Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

(2012) Marco Montagner et al.   NATURE

The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity

(2012) I Paul et al.   ONCOGENE

Drosophila Mgr, a Prefoldin subunit cooperating with von Hippel Lindau to regulate tubulin stability

(2012) N. Delgehyr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Prefoldin 5 Is Required for Normal Sensory and Neuronal Development in a Murine Model

(2010) YongSuk Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxygen Sensors at the Crossroad of Metabolism

(2009) Julián Aragonés et al.   Cell Metabolism

The Role of Hypoxia in Development of the Mammalian Embryo

(2009) Sally L. Dunwoodie   DEVELOPMENTAL CELL

Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α

(2009) Weibo Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT