A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis

The ever-expanding role of HIF in tumour and stromal biology

(2016) Edward L. LaGory et al.   NATURE CELL BIOLOGY

Expression and functionality of histone H2A variants in cancer

(2015) Fátima Liliana Monteiro et al.   Oncotarget

Hypoxia Signaling and the Metastatic Phenotype

(2014) H. Mujcic et al.   CURRENT MOLECULAR MEDICINE

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

(2012) Marco Montagner et al.   NATURE

Monoubiquitination of H2AX Protein Regulates DNA Damage Response Signaling

(2011) Mei-Ren Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response

(2011) Ching-Yuan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

(2010) Michael Hinz et al.   MOLECULAR CELL

Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development

(2010) W-L Yang et al.   ONCOGENE

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Targeting the hypoxia-inducible factor (HIF) pathway in cancer

(2009) Evon Poon et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

ATM Activation and Signaling under Hypoxic Conditions

(2008) Z. Bencokova et al.   MOLECULAR AND CELLULAR BIOLOGY

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL