HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
出版年份 2020 全文链接
标题
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
作者
关键词
-
出版物
Nature Communications
Volume 11, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-08-17
DOI
10.1038/s41467-020-17873-3
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Tumor infiltrating mast cells determine oncogenic HIF-2α-conferred immune evasion in clear cell renal cell carcinoma
- (2019) Ying Xiong et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients
- (2019) Kevin D Courtney et al. CLINICAL CANCER RESEARCH
- Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal
- (2018) Samra Turajlic et al. CELL
- Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
- (2018) Thomas J. Mitchell et al. CELL
- Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
- (2018) Samra Turajlic et al. CELL
- Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma
- (2018) Kevin D. Courtney et al. JOURNAL OF CLINICAL ONCOLOGY
- Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis
- (2018) Mikael S. Lindström et al. ONCOGENE
- An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors
- (2018) Tao Wang et al. Cancer Discovery
- seq-ImmuCC: Cell-Centric View of Tissue Transcriptome Measuring Cellular Compositions of Immune Microenvironment From Mouse RNA-Seq Data
- (2018) Ziyi Chen et al. Frontiers in Immunology
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo
- (2018) Kevin D. Courtney et al. Cell Metabolism
- Roles of the immune system in cancer: from tumor initiation to metastatic progression
- (2018) Hugo Gonzalez et al. GENES & DEVELOPMENT
- Clear cell renal cell carcinoma with wild-type von Hippel-Lindau gene: a non-existent or new tumour entity?
- (2018) Aashil A Batavia et al. HISTOPATHOLOGY
- The PRIDE database and related tools and resources in 2019: improving support for quantification data
- (2018) Yasset Perez-Riverol et al. NUCLEIC ACIDS RESEARCH
- Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice
- (2017) Sabine Harlander et al. NATURE MEDICINE
- Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL−/−clear cell renal carcinoma
- (2017) Wenhua Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis
- (2017) Judit Espana-Agusti et al. Nature Communications
- Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade
- (2017) Yi-Feng Gu et al. Cancer Discovery
- Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease
- (2017) Vanessa Drendel et al. Oncotarget
- The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma
- (2017) Amrita M. Nargund et al. Cell Reports
- HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy
- (2017) Antonella Mangraviti et al. Scientific Reports
- An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma
- (2016) A. Ari Hakimi et al. CANCER CELL
- Formation of Renal Cysts and Tumors inVhl/Trp53-Deficient Mice Requires HIF1α and HIF2α
- (2016) Désirée Schönenberger et al. CANCER RESEARCH
- Myeloid-Derived Suppressor Cell Subset Accumulation in Renal Cell Carcinoma Parenchyma Is Associated with Intratumoral Expression of IL1β, IL8, CXCL5, and Mip-1α
- (2016) Yana G. Najjar et al. CLINICAL CANCER RESEARCH
- Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin
- (2016) Navid M. Farsijani et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting renal cell carcinoma with a HIF-2 antagonist
- (2016) Wenfang Chen et al. NATURE
- On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
- (2016) Hyejin Cho et al. NATURE
- Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity
- (2016) Rouven Hoefflin et al. Nature Communications
- PBRM1 Regulates the Expression of Genes Involved in Metabolism and Cell Adhesion in Renal Clear Cell Carcinoma
- (2016) Basudev Chowdhury et al. PLoS One
- A Clearer View of the Molecular Complexity of Clear Cell Renal Cell Carcinoma
- (2015) Ian J. Frew et al. Annual Review of Pathology-Mechanisms of Disease
- Quantitative proteomic analysis of formalin–fixed, paraffin–embedded clear cell renal cell carcinoma tissue using stable isotopic dimethylation of primary amines
- (2015) J. Weißer et al. BMC GENOMICS
- Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
- (2015) Michael S. Rooney et al. CELL
- Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer
- (2015) N. A. Giraldo et al. CLINICAL CANCER RESEARCH
- Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes
- (2015) J. W. Lee et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Genome-Wide Profiling of TRACK Kidneys Shows Similarity to the Human ccRCC Transcriptome
- (2015) L. Fu et al. MOLECULAR CANCER RESEARCH
- Structural integration in hypoxia-inducible factors
- (2015) Dalei Wu et al. NATURE
- Orchestrating high-throughput genomic analysis with Bioconductor
- (2015) Wolfgang Huber et al. NATURE METHODS
- Robust enumeration of cell subsets from tissue expression profiles
- (2015) Aaron M Newman et al. NATURE METHODS
- HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model
- (2015) Tao Yin et al. ONCOLOGY RESEARCH
- Analyses of the Transcriptome and Metabolome Demonstrate That HIF1α Mediates Altered Tumor Metabolism in Clear Cell Renal Cell Carcinoma
- (2015) Denise R. Minton et al. PLoS One
- MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments
- (2014) Meena Choi et al. BIOINFORMATICS
- Trimmomatic: a flexible trimmer for Illumina sequence data
- (2014) Anthony M. Bolger et al. BIOINFORMATICS
- Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer
- (2014) Jessica E.S. Shay et al. CARCINOGENESIS
- The role of HIF1α in renal cell carcinoma tumorigenesis
- (2014) Lorraine J. Gudas et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
- (2014) Marco Gerlinger et al. NATURE GENETICS
- Gene Ontology Consortium: going forward
- (2014) NUCLEIC ACIDS RESEARCH
- The UCSC Genome Browser database: 2015 update
- (2014) Kate R. Rosenbloom et al. NUCLEIC ACIDS RESEARCH
- Conditional inactivation of the mouse von Hippel–Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory and fibrotic lesions in the kidney
- (2014) T L Pritchett et al. ONCOGENE
- Bap1is essential for kidney function and cooperates withVhlin renal tumorigenesis
- (2014) Shan-Shan Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Large (>3.8 cm) clear cell renal cell carcinomas are morphologically and immunohistochemically heterogeneous
- (2014) Laura Zaldumbide et al. VIRCHOWS ARCHIV
- Action of hypoxia-inducible factor in liver and kidney from mice with Pax8-rtTA-based deletion of von Hippel-Lindau protein
- (2013) S. Mathia et al. Acta Physiologica
- Activation of HIF2 in Kidney Proximal Tubule Cells Causes Abnormal Glycogen Deposition but not Tumorigenesis
- (2013) L. Fu et al. CANCER RESEARCH
- Proximal Tubule Function and Response to Acidosis
- (2013) N. P. Curthoys et al. Clinical Journal of the American Society of Nephrology
- Combined mutation ofVhlandTrp53causes renal cysts and tumours in mice
- (2013) Joachim Albers et al. EMBO Molecular Medicine
- Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer
- (2013) Gabriela Bindea et al. IMMUNITY
- HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
- (2013) Gregg L. Semenza JOURNAL OF CLINICAL INVESTIGATION
- Integrated molecular analysis of clear-cell renal cell carcinoma
- (2013) Yusuke Sato et al. NATURE GENETICS
- Software for Computing and Annotating Genomic Ranges
- (2013) Michael Lawrence et al. PLoS Computational Biology
- Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell renal cell carcinoma
- (2013) Stefanie Regine Dannenmann et al. OncoImmunology
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- HIF-1α protein is upregulated in HIF-2α depleted cells via enhanced translation
- (2012) Kathrin Schulz et al. FEBS LETTERS
- The ConsensusPathDB interaction database: 2013 update
- (2012) Atanas Kamburov et al. NUCLEIC ACIDS RESEARCH
- Renal Tubular HIF-2α Expression Requires VHL Inactivation and Causes Fibrosis and Cysts
- (2012) Ruth E. Schietke et al. PLoS One
- The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.
- (2012) Ethan Cerami et al. Cancer Discovery
- The Hypoxia-Associated Factor Switches Cells from HIF-1 - to HIF-2 -Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
- (2011) M. Y. Koh et al. CANCER RESEARCH
- Generation of a Mouse Model of Von Hippel-Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1
- (2011) L. Fu et al. CANCER RESEARCH
- Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis
- (2011) Federico A Monzon et al. MODERN PATHOLOGY
- Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element
- (2011) J Xu et al. ONCOGENE
- Genetic and Functional Studies Implicate HIF1 as a 14q Kidney Cancer Suppressor Gene
- (2011) C. Shen et al. Cancer Discovery
- ROAST: rotation gene set tests for complex microarray experiments
- (2010) Di Wu et al. BIOINFORMATICS
- Renal Oxygenation Suppresses VHL Loss-Induced Senescence That Is Caused by Increased Sensitivity to Oxidative Stress
- (2010) S. M. Welford et al. MOLECULAR AND CELLULAR BIOLOGY
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
- (2009) David A. Barbie et al. NATURE
- Universal sample preparation method for proteome analysis
- (2009) Jacek R Wiśniewski et al. NATURE METHODS
- Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
- (2009) K. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
- (2008) John D. Gordan et al. CANCER CELL
- pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation
- (2008) Ian J Frew et al. EMBO JOURNAL
- VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
- (2008) Arthur P. Young et al. NATURE CELL BIOLOGY
- Acute Inactivation of the VHL Gene Contributes to Protective Effects of Ischemic Preconditioning in the Mouse Kidney
- (2008) Mitsuko Iguchi et al. NEPHRON EXPERIMENTAL NEPHROLOGY
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