标题
The Conundrum of Genetic “Drivers” in Benign Conditions
作者
关键词
-
出版物
JNCI-Journal of the National Cancer Institute
Volume 108, Issue 8, Pages djw036
出版商
Oxford University Press (OUP)
发表日期
2016-04-09
DOI
10.1093/jnci/djw036
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The Case for a Pre-Cancer Genome Atlas (PCGA)
- (2016) J. D. Campbell et al. Cancer Prevention Research
- Transforming Cancer Prevention through Precision Medicine and Immune-oncology
- (2016) T. W. Kensler et al. Cancer Prevention Research
- A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation
- (2016) C. K. Kaufman et al. SCIENCE
- Oral Cancer Chemoprevention—The End of EPOC, the Beginning of an Epoch of Molecular Selection
- (2016) Julie E. Bauman et al. JAMA Oncology
- Erlotinib and the Risk of Oral Cancer
- (2016) William N. William et al. JAMA Oncology
- Molecular phenotypes of DCIS predict overall and invasive recurrence
- (2015) K. E. Williams et al. ANNALS OF ONCOLOGY
- Cancer spectrum and frequency among children with Noonan, Costello and cardio-facio-cutaneous syndromes
- (2015) C P Kratz et al. BRITISH JOURNAL OF CANCER
- The role ofBRAFmutations in primary melanoma growth rate and survival
- (2015) V.J. Mar et al. BRITISH JOURNAL OF DERMATOLOGY
- Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications
- (2015) Teresa Helsten et al. CANCER AND METASTASIS REVIEWS
- HER2 expression status in diverse cancers: review of results from 37,992 patients
- (2015) Min Yan et al. CANCER AND METASTASIS REVIEWS
- Colon Tumors with the Simultaneous Induction of Driver Mutations in APC, KRAS, and PIK3CA Still Progress through the Adenoma-to-carcinoma Sequence
- (2015) J. N. Hadac et al. Cancer Prevention Research
- Fibroblast growth factor family aberrations in cancers: clinical and molecular characteristics
- (2015) A Parish et al. CELL CYCLE
- Next generation sequencing demonstrates association between tumor suppressor gene aberrations and poor outcome in patients with cancer
- (2015) Maria Schwaederle et al. CELL CYCLE
- Cyclin-dependent kinase pathway aberrations in diverse malignancies: clinical and molecular characteristics
- (2015) Shumei Kato et al. CELL CYCLE
- The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing
- (2015) T. Helsten et al. CLINICAL CANCER RESEARCH
- Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials
- (2015) Funda Meric-Bernstam et al. JOURNAL OF CLINICAL ONCOLOGY
- Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas
- (2015) Michael Krauthammer et al. NATURE GENETICS
- Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy
- (2015) Michael Y Zhang et al. NATURE GENETICS
- The Genetic Evolution of Melanoma from Precursor Lesions
- (2015) A. Hunter Shain et al. NEW ENGLAND JOURNAL OF MEDICINE
- Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations
- (2015) David M. Hyman et al. NEW ENGLAND JOURNAL OF MEDICINE
- High burden and pervasive positive selection of somatic mutations in normal human skin
- (2015) I. Martincorena et al. SCIENCE
- Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA
- (2015) Evgeny Izumchenko et al. Nature Communications
- CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma
- (2015) A. S. McNeal et al. Cancer Discovery
- NF2/Merlin in hereditary neurofibromatosis 2 versus cancer: biologic mechanisms and clinical associations
- (2015) Rebecca Dunbar Schroeder et al. Oncotarget
- P53 Mutations in Advanced Cancers: Clinical Characteristics, Outcomes, and Correlation between Progression-Free Survival and Bevacizumab-Containing Therapy
- (2015) Rabih Said et al. Oncotarget
- Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity
- (2015) Adrienne L. Watson et al. Oncotarget
- Clinicopathological Significance of CDKN2A Promoter Hypermethylation Frequency with Pancreatic Cancer
- (2015) Bo Tang et al. Scientific Reports
- Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
- (2014) Patricia A.J. Muller et al. CANCER CELL
- Dragging Ras Back in the Ring
- (2014) Andrew G. Stephen et al. CANCER CELL
- Molecular Profiling of Premalignant Lesions in Lung Squamous Cell Carcinomas Identifies Mechanisms Involved in Stepwise Carcinogenesis
- (2014) A. T. Ooi et al. Cancer Prevention Research
- Notch1 Mutations Are Drivers of Oral Tumorigenesis
- (2014) E. Izumchenko et al. Cancer Prevention Research
- Loss of NF1 in Cutaneous Melanoma Is Associated with RAS Activation and MEK Dependence
- (2014) Moriah H. Nissan et al. CANCER RESEARCH
- HER2 aberrations in cancer: Implications for therapy
- (2014) Min Yan et al. CANCER TREATMENT REVIEWS
- Crizotinib in Advanced, Chemoresistant Anaplastic Lymphoma Kinase–Positive Lymphoma Patients
- (2014) Carlo Gambacorti Passerini et al. JNCI-Journal of the National Cancer Institute
- Drugging the undruggable RAS: Mission Possible?
- (2014) Adrienne D. Cox et al. NATURE REVIEWS DRUG DISCOVERY
- Ceritinib in ALK-Rearranged Non–Small-Cell Lung Cancer
- (2014) Alice T. Shaw et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence
- (2014) Giulio Genovese et al. NEW ENGLAND JOURNAL OF MEDICINE
- Near-genomewide RNAi screening for regulators of BRAFV600E-induced senescence identifiesRASEF, a gene epigenetically silenced in melanoma
- (2014) Joanna Kaplon et al. Pigment Cell & Melanoma Research
- KRAS: feeding pancreatic cancer proliferation
- (2014) Kirsten L. Bryant et al. TRENDS IN BIOCHEMICAL SCIENCES
- Defining Key Signaling Nodes and Therapeutic Biomarkers in NF1-Mutant Cancers
- (2014) C. F. Malone et al. Cancer Discovery
- Assessing PIK3CA and PTEN in Early-Phase Trials with PI3K/AKT/mTOR Inhibitors
- (2014) Filip Janku et al. Cell Reports
- Melanoma patients in a phase I clinic: molecular aberrations, targeted therapy and outcomes
- (2013) H. Henary et al. ANNALS OF ONCOLOGY
- The RASopathies
- (2013) Katherine A. Rauen Annual Review of Genomics and Human Genetics
- European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013
- (2013) M. Baccarani et al. BLOOD
- NRAS Mutation Is the Sole Recurrent Somatic Mutation in Large Congenital Melanocytic Nevi
- (2013) Christelle Charbel et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Melanoma prone families withCDK4germline mutation: phenotypic profile and associations withMC1Rvariants
- (2013) Hanne Eknes Puntervoll et al. JOURNAL OF MEDICAL GENETICS
- BRAF mutational epidemiology in dysplastic nevi: Does different solar UV radiation exposure matter?
- (2013) M. Saroufim et al. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
- Clonal BRAF Mutations in Melanocytic Nevi and Initiating Role of BRAF in Melanocytic Neoplasia
- (2013) Iwei Yeh et al. JNCI-Journal of the National Cancer Institute
- Non–Small-Cell Lung Cancer with HER2 Exon 20 Mutation: Regression with Dual HER2 Inhibition and Anti-VEGF Combination Treatment
- (2013) Gerald S. Falchook et al. Journal of Thoracic Oncology
- Mutational landscape and significance across 12 major cancer types
- (2013) Cyriac Kandoth et al. NATURE
- Sturge–Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ
- (2013) Matthew D. Shirley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Crizotinib versus Chemotherapy in Advanced ALK-Positive Lung Cancer
- (2013) Alice T. Shaw et al. NEW ENGLAND JOURNAL OF MEDICINE
- NRAS and BRAF Mutations in Melanoma-Associated Nevi and Uninvolved Nevi
- (2013) Philipp Tschandl et al. PLoS One
- Dynamic Changes in Nevi of a Patient With Melanoma Treated With Vemurafenib
- (2012) Holger A. Haenssle et al. ARCHIVES OF DERMATOLOGY
- Mechanisms of FGFR-mediated carcinogenesis
- (2012) Imran Ahmad et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- HER2/neu and Ki-67 expression predict non-invasive recurrence following breast-conserving therapy for ductal carcinoma in situ
- (2012) E Rakovitch et al. BRITISH JOURNAL OF CANCER
- Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
- (2012) M. Endo et al. CLINICAL CANCER RESEARCH
- Personalized Medicine in a Phase I Clinical Trials Program: The MD Anderson Cancer Center Initiative
- (2012) A.-M. Tsimberidou et al. CLINICAL CANCER RESEARCH
- Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
- (2012) L. C. W. Vredeveld et al. GENES & DEVELOPMENT
- Costello syndrome: a Ras/mitogen activated protein kinase pathway syndrome (rasopathy) resulting from HRAS germline mutations
- (2012) Karen W. Gripp et al. GENETICS IN MEDICINE
- MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors
- (2012) Walter J. Jessen et al. JOURNAL OF CLINICAL INVESTIGATION
- PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies HarboringPIK3CAMutations
- (2012) Filip Janku et al. JOURNAL OF CLINICAL ONCOLOGY
- Atypical Melanocytic Proliferations and New Primary Melanomas in Patients With Advanced Melanoma Undergoing SelectiveBRAFInhibition
- (2012) Lisa Zimmer et al. JOURNAL OF CLINICAL ONCOLOGY
- Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome
- (2012) Nathan T. Ihle et al. JNCI-Journal of the National Cancer Institute
- Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial
- (2012) Gerald S Falchook et al. LANCET
- Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
- (2012) Axel Hauschild et al. LANCET
- Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial
- (2012) Gerald S Falchook et al. LANCET ONCOLOGY
- Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
- (2012) Rafael Rosell et al. LANCET ONCOLOGY
- Passenger deletions generate therapeutic vulnerabilities in cancer
- (2012) Florian L. Muller et al. NATURE
- Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA
- (2012) Marjorie J Lindhurst et al. NATURE GENETICS
- De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly
- (2012) Jeong Ho Lee et al. NATURE GENETICS
- Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib
- (2012) Jeffrey A. Sosman et al. NEW ENGLAND JOURNAL OF MEDICINE
- RASMutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
- (2012) Fei Su et al. NEW ENGLAND JOURNAL OF MEDICINE
- MAP kinase signaling and inhibition in melanoma
- (2012) R J Sullivan et al. ONCOGENE
- Cancer in Noonan, Costello, cardiofaciocutaneous and LEOPARD syndromes
- (2011) Christian P. Kratz et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
- Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes
- (2011) Kenneth L. Scott et al. CANCER CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- A novel tyrosine kinase inhibitor restores chondrocyte differentiation and promotes bone growth in a gain-of-function Fgfr3 mouse model
- (2011) Aurélie Jonquoy et al. HUMAN MOLECULAR GENETICS
- Prognostic and Clinicopathologic Associations of OncogenicBRAFin Metastatic Melanoma
- (2011) Georgina V. Long et al. JOURNAL OF CLINICAL ONCOLOGY
- Treatment of Patients With Advanced Neurofibromatosis Type 2 With Novel Molecularly Targeted Therapies: From Bench to Bedside
- (2011) Vivek Subbiah et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors
- (2011) Johanna C. Bendell et al. JOURNAL OF CLINICAL ONCOLOGY
- Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
- (2011) Caicun Zhou et al. LANCET ONCOLOGY
- Targeting Oncogenic ALK: A Promising Strategy for Cancer Treatment
- (2011) E. Grande et al. MOLECULAR CANCER THERAPEUTICS
- Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
- (2011) Paul B. Chapman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
- (2011) N. J. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Circulating Benign Nevus Cells Detected by ISET Technique
- (2010) Vincenzo De Giorgi et al. ARCHIVES OF DERMATOLOGY
- Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
- (2010) Roel G.W. Verhaak et al. CANCER CELL
- Integrative Genomic Profiling of Human Prostate Cancer
- (2010) Barry S. Taylor et al. CANCER CELL
- IGFBP7 Is Not Required for B-RAF-Induced Melanocyte Senescence
- (2010) Lyndee L. Scurr et al. CELL
- PIK3CA Mutations May Be Discordant between Primary and Corresponding Metastatic Disease in Breast Cancer
- (2010) J. Dupont Jensen et al. CLINICAL CANCER RESEARCH
- Cellular senescence: putting the paradoxes in perspective
- (2010) Judith Campisi CURRENT OPINION IN GENETICS & DEVELOPMENT
- FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes
- (2010) Christian Hafner et al. EXPERIMENTAL CELL RESEARCH
- Activation of the PI3K/AKT signalling pathway in non-melanoma skin cancer is not mediated by oncogenic PIK3CA and AKT1 hotspot mutations
- (2010) Christian Hafner et al. EXPERIMENTAL DERMATOLOGY
- Ductal Carcinoma In Situ of the Breast: A Systematic Review of Incidence, Treatment, and Outcomes
- (2010) B. A. Virnig et al. JNCI-Journal of the National Cancer Institute
- Crizotinib inALK-Rearranged Inflammatory Myofibroblastic Tumor
- (2010) James E. Butrynski et al. NEW ENGLAND JOURNAL OF MEDICINE
- Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR
- (2010) Makoto Maemondo et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutations inGNA11in Uveal Melanoma
- (2010) Catherine D. Van Raamsdonk et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pancreatic Cancer
- (2010) Manuel Hidalgo NEW ENGLAND JOURNAL OF MEDICINE
- Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors
- (2010) C. Hafner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Airway PI3K Pathway Activation Is an Early and Reversible Event in Lung Cancer Development
- (2010) A. M. Gustafson et al. Science Translational Medicine
- Activation of fibroblast growth factor receptor 3 and oncogene-induced senescence in skin tumours
- (2009) Y. Hida et al. BRITISH JOURNAL OF DERMATOLOGY
- Genetic Subgrouping of Melanoma Reveals New Opportunities for Targeted Therapy
- (2009) K. S.M. Smalley et al. CANCER RESEARCH
- The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation
- (2009) William E Tidyman et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Lack of Correlation between IGFBP7 Expression and BRAF Mutational Status in Melanoma
- (2009) David Schrama et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Neurofibromatosis type 1
- (2009) Kevin P. Boyd et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- A comprehensive catalogue of somatic mutations from a human cancer genome
- (2009) Erin D. Pleasance et al. NATURE
- The cancer genome
- (2009) Michael R. Stratton et al. NATURE
- Neurofibromatosis type 2 (NF2): A clinical and molecular review
- (2009) D Gareth R Evans Orphanet Journal of Rare Diseases
- IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial
- (2008) P. Emery et al. ANNALS OF THE RHEUMATIC DISEASES
- Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
- (2008) Narendra Wajapeyee et al. CELL
- Cellular senescence in vivo: a barrier to tumorigenesis
- (2008) Alexandre Prieur et al. CURRENT OPINION IN CELL BIOLOGY
- In melanocytic lesions the fraction of BRAFV600E alleles is associated with sun exposure but unrelated to ERK phosphorylation
- (2008) Tiziana Venesio et al. MODERN PATHOLOGY
- Somatic mutations affect key pathways in lung adenocarcinoma
- (2008) Li Ding et al. NATURE
- K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer
- (2008) Christos S. Karapetis et al. NEW ENGLAND JOURNAL OF MEDICINE
- Many roads lead to oncogene-induced senescence
- (2008) S Courtois-Cox et al. ONCOGENE
- An Integrated Genomic Analysis of Human Glioblastoma Multiforme
- (2008) D. W. Parsons et al. SCIENCE
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