Article
Oncology
Ana Zulijani, Andrea Dekanic, Tomislav Cabov, Hrvoje Jakovac
Summary: The study evaluated the relationship and possible interactions between metallothioneins and megalin in different grades of oral squamous cell carcinoma and premalignant lesions, showing their co-expression and direct interaction in cancer tissue, indicating the oncogenic potential of the MTs-megalin interaction.
Article
Multidisciplinary Sciences
Vei Mah, Yahya Elshimali, Alison Chu, Neda A. Moatamed, Jamar P. Uzzell, Jessica Tsui, Stephen Schettler, Hania Shakeri, Madhuri Wadehra
Summary: The expression of ALDH1 in endometrial hyperplasia and cancer showed significant changes, suggesting its potential as an early marker for predicting endometrial cancer development. This study suggests that ALDH1 can serve as an independent prognostic indicator for patients with endometrial hyperplasia who may progress to cancer.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Sigrid Regauer, Olaf Reich, Karl Kashofer
Summary: This study provides a detailed characterization of HPV-negative cervical carcinoma, including the identification of different types of precursor lesions and the analysis of genetic mutations and chromosomal variations. The findings suggest that genetic factors and inflammatory infiltrate may contribute to the development of HPV-negative cervical cancer.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Oncology
Asaf Maoz, Carter Merenstein, Yusuke Koga, Austin Potter, Adam C. Gower, Gang Liu, Sherry Zhang, Hanqiao Liu, Christopher Stevenson, Avrum Spira, Mary E. Reid, Joshua D. Campbell, Sarah A. Mazzilli, Marc E. Lenburg, Jennifer Beane
Summary: This study characterized the T cell receptor repertoire in bronchial premalignant lesions (PMLs) using RNA-seq data, revealing an association between TCR diversity and immune activation signatures in PMLs. The study also found differences in TCR diversity between regressive and progressive/persistent PMLs and identified shared TCR sequences with potential antigen specificities in PML samples.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Lori D. Dwyer-Nield, Debbie G. McArthur, Tyler M. Hudish, Laura I. Hudish, Carol Mirita, Kayla Sompel, Alex J. Smith, Kiana Alavi, Moumita Ghosh, Daniel T. Merrick, Meredith A. Tennis, Robert L. Keith
Summary: Pioglitazone significantly reduces squamous lesions and the presence of airway basal cells in the NTCU mouse model. It also influences EMT gene expression to promote a more epithelial phenotype. These findings contribute to the understanding of PPAR gamma agonism as a chemoprevention strategy for lung cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Weiqing Wang, Yi Xu, Lun Wang, Zhenzhen Zhu, Surita Aodeng, Hui Chen, Menghua Cai, Zhihao Huang, Jinbo Han, Lei Wang, Yuxi Lin, Yu Hu, Liangrui Zhou, Xiaowei Wang, Yang Zha, Weihong Jiang, Zhiqiang Gao, Wei He, Wei Lv, Jianmin Zhang
Summary: The study utilized single-cell RNA sequencing to identify cell subsets and molecules involved in the pathogenesis of chronic rhinosinusitis subtypes. The findings expand our understanding of the immune microenvironment and pathogenesis of CRS subtypes, and suggest potential therapeutic approaches for CRS and other type 2 immunity-mediated diseases.
Article
Cell Biology
Lulu Sun, Xindan Kang, Chong Wang, Rui Wang, Guizhu Yang, Wen Jiang, Qi Wu, Yujue Wang, Yaping Wu, Jiamin Gao, Lan Chen, Jie Zhang, Zhen Tian, Guopei Zhu, Shuyang Sun
Summary: This study analyzed oral mucosal biopsies from 9 individuals with very early-stage OSCC, adjacent precancerous lesions, and normal regions. It revealed altered gene expression profiles, distinct cell subclusters, and immune regulation surrounding precancerous lesions, all of which contribute to OSCC initiation.
Review
Virology
Tania Guadalupe Heredia-Torres, Ana Rosa Rincon-Sanchez, Sonia Amelia Lozano-Sepulveda, Kame Galan-Huerta, Daniel Arellanos-Soto, Marisela Garcia-Hernandez, Aurora de Jesus Garza-Juarez, Ana Maria Rivas-Estilla
Summary: Viral infection-induced cancer is a major cause of cancer development, with HCV being a virus that causes chronic liver infection. The virus promotes liver cancer development through various molecular mechanisms, but recent treatments with DAAs have also shown an increased risk of early HCC occurrence in some cases. Therefore, a better understanding of molecular mechanisms and therapeutic targets is crucial.
Review
Agriculture, Dairy & Animal Science
Cristian G. Torres, Maria P. Iturriaga, Pamela Cruz
Summary: Canine mammary cancer is a tumor disease that often affects intact female dogs, with hormonal factors playing a key role in its development. Estradiol, primarily produced in the ovaries, can induce various stages of mammary carcinogenesis, although the underlying mechanisms remain incompletely understood. High concentrations of estradiol have been found in malignant mammary tumor tissue, with its action involving both genomic and non-genomic effects on intracellular signaling pathways.
Article
Oncology
Lori D. Dwyer-Nield, Debbie G. McArthur, Meredith A. Tennis, Daniel T. Merrick, Robert L. Keith
Summary: By enhancing the NTCU + CS mouse model, researchers have increased the number of premalignant lesions, reduced the number of mice needed, and decreased the time required for PML development, making it more suitable for preclinical studies.
CANCER PREVENTION RESEARCH
(2021)
Article
Cell Biology
Horst Penkert, Alix Bertrand, Vini Tiwari, Stephan Breimann, Stephan A. Mueller, Paul M. Jordan, Mathias J. Gerl, Christian Klose, Ludovico Cantuti-Castelvetri, Mar Bosch-Queralt, Ilya Levental, Stefan F. Lichtenthaler, Oliver Werz, Mikael Simons
Summary: The study reveals that n-3 fatty acids can promote the balance of inflammatory reactions, reduce phagocytic infiltrate, accelerate the decline of microglia/macrophages, enhance oligodendrocyte generation, and ultimately improve lesion recovery in demyelinating injuries of the central nervous system.
Article
Oncology
Bertine W. Huisman, Merve Cankat, Tjalling Bosse, Alexander L. Vahrmeijer, Robert Rissmann, Jacobus Burggraaf, Cornelis F. M. Sier, Mariette I. E. van Poelgeest
Summary: Fluorescence-guided surgery using integrin alpha v beta 6 as a target showed robust discrimination of vulvar tumors and surrounding tissue, suggesting its potential utility in future studies. Immunohistochemistry of membrane proteins identified possible tracers for fluorescence-guided surgery in vulvar (pre)malignancies, emphasizing the need for further evaluation of alpha v beta 6 as a target.
Article
Medicine, General & Internal
Mateusz Bujko, Kamil Zalewski, Martyna Szczyrek, Artur Kowalik, Joanna Boresowicz, Angelika Dlugosz, Krzysztof Goryca, Stanislaw Gozdz, Magdalena Kowalewska
Summary: This study investigated the diagnostic value of circulating hsa-miR-431-5p in vulvar precancers and VSCC. Higher levels of miR-431-5p were observed in VSCC patients compared to those with vulvar precancers, and its levels were predictive of survival rates in VSCC patients.
Review
Cell Biology
Ana Belen Griso, Lucia Acero-Riaguas, Beatriz Castelo, Jose Luis Cebrian-Carretero, Ana Sastre-Perona
Summary: This review examines the mechanisms involved in the development of cisplatin resistance in head and neck squamous cell carcinomas (HNSCCs) and discusses potential strategies to overcome these complications. Classical resistance mechanisms and the prevalence of these mechanisms in the population of cancer stem cells (CSC) are highlighted. The influence of cell intrinsic and extrinsic cues, as well as the stromal composition and tumor microenvironment, on resistance and CSC characteristics are also discussed. Furthermore, the impact of epigenetic modifiers and signaling pathways on tumor behavior and cell plasticity in inducing chemotherapy resistance is explored.
Article
Oncology
Andrea Necchi, Philippe E. Spiess, Marco Bandini, Giuseppe Basile, Petros Grivas, Gennady Bratslavsky, Joseph Jacob, Natalie Danziger, Douglas Lin, Brennan Decker, Ethan S. Sokol, Richard S. P. Huang, Sanjay B. Kulkarni, Jeffrey S. Ross
Summary: This study assesses genomic differences among a large series of pelvic squamous cell carcinoma (pSCC) cases to determine whether pSCC could potentially benefit from targeted therapies and/or immunotherapy.
Article
Oncology
Su Yon Jung, Peter A. Scott, Jeanette C. Papp, Eric M. Sobel, Matteo Pellegrini, Herbert Yu, Sihao Han, Zuo-Feng Zhang
Summary: The study identified interactions between immune-related etiologic pathways and lifestyle factors that influence invasive breast cancer risk. Specific genetic SNPs associated with proinflammatory cytokines were found to be connected to breast cancer risk, suggesting potential intervention strategies for women carrying these risk genotypes.
CANCER PREVENTION RESEARCH
(2021)
Article
Respiratory System
Elizabeth J. Becker, Alen Faiz, Maarten van den Berge, Wim Timens, Pieter S. Hiemstra, Kristopher Clark, Gang Liu, Xiaohui Xiao, Yuriy O. Alekseyev, George O'Connor, Stephen Lam, Avrum Spira, Marc E. Lenburg, Katrina Steiling
Summary: The study identified and replicated an airway gene expression signature associated with the rate of FEV1 decline in individuals with COPD. Genes that are elevated in individuals with a more rapid FEV1 decline are significantly enriched among the genes altered by modulation of XBP1 and are related to mucin production. These findings suggest that molecular processes related to the rate of FEV1 decline can be detected in the airway epithelium, potentially serving as an early indicator of rapid FEV1 decline in both smokers with and without COPD.
Article
Biochemistry & Molecular Biology
Monica Cappelletti, Pietro Presicce, Ma Feiyang, Paranthaman Senthamaraikannan, Lisa A. Miller, Matteo Pellegrini, Myung S. Sim, Alan H. Jobe, Senad Divanovic, Sing Sing Way, Claire A. Chougnet, Suhas G. Kallapur
Summary: The study explores the relationship between intrauterine infection/inflammation (IUI) and preterm labor (PTL). Using rhesus macaque models, researchers found that the intensity of the host immune response to IUI may determine susceptibility to PTL. Animals infected with live Escherichia coli showed higher levels of inflammatory mediators, particularly interleukin 6 (IL-6) and prostaglandins, leading to preterm delivery.
Article
Biochemistry & Molecular Biology
Su Yon Jung, Jeanette C. Papp, Matteo Pellegrini, Herbert Yu, Eric M. Sobel
Summary: The study utilized an integrated genomic network approach to explore the role of CRP/IL6 in disease pathogenesis. It identified shared gene networks and regulatory mechanisms between CRP/IL6 and diseases like breast cancer, offering potential novel genetic targets for prevention and treatment strategies for associated disorders.
Article
Biochemistry & Molecular Biology
Colin Farrell, Maria Vaquero-Sedas, Maria D. Cubiles, Michael Thompson, Alejandro Vega-Vaquero, Matteo Pellegrini, Miguel A. Vega-Palas
Summary: DNA methylation modulates telomere function in Arabidopsis thaliana, where subtelomeric DNA methylation extends from Interstitial Telomeric Sequences (ITSs) near telomeres. However, it drops at the telomeric side and disappears at the inner part of telomeres.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Cell Biology
Kalsuda Lapborisuth, Colin Farrell, Matteo Pellegrini
Summary: This study uses pseudotime analysis to determine the functional form of DNA methylation trajectories, which show a nonlinear relationship with time. The results indicate that the pseudotime trajectory can be modeled using a sum of two exponentials, with coefficients close to human age-associated mortality timescales. This allows for the identification of age-associated molecular changes that appear to track the exponential dynamics of mortality risk.
Article
Hematology
Jocelynda Salvador, Gloria E. Hernandez, Feiyang Ma, Cyrus W. Abrahamson, Matteo Pellegrini, Robert Goldman, Karen M. Ridge, M. Luisa Iruela-Arispe
Summary: This study revealed the unexpected contribution of vimentin in driving complete closure of the ductus arteriosus through a mechanism that includes deregulation of the Notch signaling pathway, through single-cell RNA-sequencing and tracking closure of the ductus arteriosus in mice.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marco Morselli, Colin Farrell, Dennis Montoya, Tarik Goren, Ramazan Sabirli, Ibrahim Turkcuer, Ozgur Kurt, Aylin Koseler, Matteo Pellegrini
Summary: The composition of immune cell types changes with age, impacting the response to infectious diseases. By profiling epigenetic marks of immune cells, we can predict pneumonia diagnosis and SARS-CoV-2 viral genome positivity. This DNA methylation-based approach also allows for the prediction of pneumonia severity.
Article
Biochemistry & Molecular Biology
Yuko Tsukahara, Beatriz Ferran, Erika T. Minetti, Brian S. H. Chong, Adam C. Gower, Markus M. Bachschmid, Reiko Matsui
Summary: Upregulation of Glrx inhibits liver fibrosis induced by aging or a high-fat, high-fructose diet. This effect is achieved by regulating apoptosis, oxidative stress, and immune pathways.
Article
Plant Sciences
Leila R. Fletcher, Christine Scoffoni, Colin Farrell, Thomas N. Buckley, Matteo Pellegrini, Lawren Sack
Summary: Research has found that there is a decoupling between relative growth rate and adaptation to cold or dry climates in Arabidopsis ecotypes. This decoupling is consistent with the presence of multiple stress resistance and avoidance mechanisms, contributing to the wide geographic range and resilience of the species.
Article
Respiratory System
Ke Xu, Alejandro A. Diaz, Fenghai Duan, Minyi Lee, Xiaohui Xiao, Hanqiao Liu, Gang Liu, Michael H. Cho, Adam C. Gower, Yuriy O. Alekseyev, Avrum Spira, Denise R. Aberle, George R. Washko, Ehab Billatos, Marc E. Lenburg
Summary: Studying gene expression alterations in individuals with radiological bronchiectasis without a clinical diagnosis can enhance our understanding of the early-stage bronchiectasis process.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Marco Morselli, Ronan Bennett, Nikko-Ideen Shaidani, Marko Horb, Leonid Peshkin, Matteo Pellegrini
Summary: This study finds that age-associated changes in DNA methylation also exist in amphibians, and whole-genome bisulfite sequencing (WGBS) profiles from skin samples of nine frogs were used to characterize the gene- and chromosome-scale features of age-associated DNA methylation changes. The results suggest that the mechanism of DNA methylation changes in amphibians is similar to that in mammals. Additionally, a targeted DNA methylation analysis (TBSseq) assay was developed for future studies with larger cohorts of individuals. The findings of this study will contribute to understanding the relationship between DNA methylation and other hallmarks of aging using the unique resources available for Xenopus.
Article
Cell Biology
Giulia Protti, Liudmilla Rubbi, Tarik Goren, Ramazan Sabirli, Serkan Civlan, Ozgur Kurt, Ibrahim Turkcuer, Aylin Koseler, Matteo Pellegrini
Summary: This study aimed to investigate the association between the methylome of buccal epithelial cells and demographic and health-related variables. Multiple factors, including age, sex, blood immune composition, and hemoglobin levels, were found to accurately model DNA methylation variation. The identified genomic loci associated with these factors were enriched in relevant transcription factors, drugs, and diseases. This study contributes to a better understanding of human methylome plasticity and highlights the potential clinical implications of considering these physiological traits in medical epigenomic investigations.
PHYSIOLOGICAL GENOMICS
(2023)
Article
Multidisciplinary Sciences
Atish Mohanty, Arin Nam, Saumya Srivastava, Jeff Jones, Brett Lomenick, Sharad S. Singhal, Linlin Guo, Hyejin Cho, Aimin Li, Amita Behal, Tamara Mirzapoiazova, Erminia Massarelli, Marianna Koczywas, Leonidas D. Arvanitis, Tonya Walser, Victoria Villaflor, Stanley Hamilton, Isa Mambetsariev, Martin Sattler, Mohd W. Nasser, Maneesh Jain, Surinder K. Batra, Raffaella Soldi, Sunil Sharma, Marwan Fakih, Saswat Kumar Mohanty, Avijit Mainan, Xiwei Wu, Yihong Chen, Yanan He, Tsui-Fen Chou, Susmita Roy, John Orban, Prakash Kulkarni, Ravi Salgia
Summary: This study reveals non-genetic mechanisms of resistance to sotorasib and proposes a treatment strategy to enhance sensitivity by targeting both ITGB4 and beta-catenin.
Article
Biochemistry & Molecular Biology
Feiyang Ma, Patrice A. Salome, Sabeeha S. Merchant, Matteo Pellegrini
Summary: By using single-cell RNA sequencing, researchers were able to analyze the heterogeneity of algal cell populations under different growth conditions, successfully separating cells into distinct clusters. Despite similar tendencies to arrest photosynthesis and cell division under iron or nitrogen deficiency, cells could still be distinguished. These findings highlighted the hidden variability within cell populations.