A novel tyrosine kinase inhibitor restores chondrocyte differentiation and promotes bone growth in a gain-of-function Fgfr3 mouse model

Delayed bone age due to a dual effect of FGFR3 mutation in Achondroplasia

(2010) Stéphanie Pannier et al.   BONE

Achondroplasia: pathogenesis and implications for future treatment

(2010) Melanie B Laederich et al.   CURRENT OPINION IN PEDIATRICS

Discovery of Novel Fibroblast Growth Factor Receptor 1 Kinase Inhibitors by Structure-Based Virtual Screening

(2010) Krishna P. Ravindranathan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of a triazole-based library of pyrido[2,3-d]pyrimidines as FGFR3 tyrosine kinase inhibitors

(2010) Laurent Le Corre et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Receptor- and ligand-based 3D-QSAR study for a series of non-nucleoside HIV-1 reverse transcriptase inhibitors

(2009) Rongjing Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The role of Akt1 in terminal stages of endochondral bone formation: Angiogenesis and ossification

(2009) Veronica Ulici et al.   BONE

1-tert-Butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a Selective Tyrosine Kinase Inhibitor of Fibroblast Growth Factor Receptor-3 (FGFR3), Inhibits Cell Proliferation of Bladder Cancer Carrying the FGFR3 Gene Mutation along with Up-Regulation of p27/Kip1 and G1/G0 Arrest

(2009) M. Miyake et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

C/EBPβ Promotes Transition from Proliferation to Hypertrophic Differentiation of Chondrocytes through Transactivation of p57Kip2

(2009) Makoto Hirata et al.   PLoS One

New Insight on FGFR3-Related Chondrodysplasias Molecular Physiopathology Revealed by Human Chondrocyte Gene Expression Profiling

(2009) Laurent Schibler et al.   PLoS One

FGFs in endochondral skeletal development

(2009) William A. Horton et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Activating Fgfr3 Y367C mutation causes hearing loss and inner ear defect in a mouse model of chondrodysplasia

(2008) Stéphanie Pannier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

STAT1 and STAT3 do not participate in FGF-mediated growth arrest in chondrocytes

(2008) P. Krejci et al.   JOURNAL OF CELL SCIENCE

Cellular interaction through LewisX cluster: theoretical studies

(2008) Yun Luo et al.   JOURNAL OF MOLECULAR MODELING