Construction of C2‐Spirocyclopropyl‐Indolin‐3‐Ones through Base‐Promoted [2+1] Annulation Reaction of Indolin‐3‐ones with Bromosulfonium Salts

Stereoselective domino reactions in the synthesis of spiro compounds

(2022) Regina Westphal et al.   SYNTHESIS-STUTTGART

One‐Pot Asymmetric Oxidative Dearomatization of 2‐Substituted Indoles by Merging Transition Metal Catalysis with Organocatalysis to Access C2‐Tetrasubstituted Indolin‐3‐Ones

(2022) Yong‐Long Zhao et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent updates on the stereoselective synthesis of structurally functionalized spiro-oxindoles mediated by isatin N, N´‑cyclic azomethine imine 1, 3-dipoles

(2022) Biplob Borah et al.   TETRAHEDRON LETTERS

Expedited Total Synthesis of (±)-Brevianamide A via the Strategic Use of Gold(I) Catalysis

(2022) Ali Mansour et al.   ORGANIC LETTERS

Syntheses and Applications of Spirocyclopropyl Oxindoles: A Decade Review

(2021) Akash P. Sakla et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Practical Stereoselective Synthesis of C3‐Spirooxindole‐ and C2‐Spiropseudoindoxyl‐Pyrrolidines via Organocatalyzed Pictet‐Spengler Reaction/Oxidative Rearrangement Sequence

(2021) Masaru Kondo et al.   ADVANCED SYNTHESIS & CATALYSIS

4‐Aryl‐2‐Imino‐1,3‐Dithiolanes from the Room Temperature Coupling of Sodium Dithiocarbamates with Sulfonium Salts

(2021) Giulio Bresciani et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Structural insights of oxindole based kinase inhibitors as anticancer agents: Recent advances

(2021) Prajwal Dhokne et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion

(2021) G. Stuart Cockerill et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Spiro[benzo[ b ]thiophene‐2(3 H ),1′‐cyclopropan]‐3‐ones via Domino Reaction Between Thioaurones and Sulfur Ylides

(2021) Yayue Dai et al.   Asian Journal of Organic Chemistry

Unified total synthesis of the brevianamide alkaloids enabled by chemical investigations into their biosynthesis

(2021) Robert C. Godfrey et al.   Chemical Science

Discovery and structure-activity relationships of spiroindolines as novel inducers of oligodendrocyte progenitor cell differentiation

(2020) Katsushi Katayama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent Advances in the Construction of Trifluoromethyl‐Containing Spirooxindoles through Cycloaddition Reactions

(2020) Hou-Ze Gui et al.   Chemistry-An Asian Journal

Stereocontrolled Synthesis of (±)-Melokhanine E via an Intramolecular Formal [3 + 2] Cycloaddition

(2020) Anna E. Cholewczynski et al.   ORGANIC LETTERS

Catalytic Enantioselective Ring-Opening Reactions of Cyclopropanes

(2020) Vincent Pirenne et al.   CHEMICAL REVIEWS

Organocatalytic Synthesis of chiral Spirooxindoles with quaternary stereogenic centers

(2020) Estibaliz Sansinenea et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Diastereoselective Construction of Cyclopropane-Fused Tetrahydroquinolines via a Sequential [4 + 2]/[2 + 1] Annulation Reaction

(2020) Zhen-Hua Wang et al.   ORGANIC LETTERS

Synthetic Approaches to Contemporary Drugs that Contain the Cyclopropyl Moiety

(2020) Zdenko Časar   SYNTHESIS-STUTTGART

Domino Relay Olefin Metathesis of Triallyl Oxindole and Indole Precursors to Access Cyclic Indoxyls and Carbazoles

(2020) Jyotirmayee Dash et al.   ChemCatChem

Selective Carbon–Carbon Bond Cleavage of Cyclopropylamine Derivatives

(2020) Olga O. Sokolova et al.   CHEMICAL REVIEWS

Bypassing the Inertness of Aziridine/CO 2 Systems to Access 5‐Aryl‐2‐Oxazolidinones: Catalyst‐Free Synthesis Under Ambient Conditions

(2020) Giulio Bresciani et al.   ChemSusChem

Recent Advances in Stereoselective Ring Expansion of Spirocyclopropanes: Access to the Spirocyclic Compounds

(2020) Tanumay Sarkar et al.   ACS Omega

Advances in the Synthesis of Benzo‐Fused Spiro Nitrogen Heterocycles: New Approaches and Modification of Old Strategies

(2020) Rail R. Gataullin   HELVETICA CHIMICA ACTA

Donor-Acceptor Cyclopropanes in the Synthesis of Carbocycles

(2019) Olga A. Ivanova et al.   CHEMICAL RECORD

Bond-Forming and -Breaking Reactions at Sulfur(IV): Sulfoxides, Sulfonium Salts, Sulfur Ylides, and Sulfinate Salts

(2019) Daniel Kaiser et al.   CHEMICAL REVIEWS

Organocatalytic Asymmetric α-Sulfenylation of 2-Substituted Indolin-3-ones: A Strategy for the Synthesis of Chiral 2,2-Disubstituted Indole-3-ones with S- and N-Containing Heteroquaternary Carbon Stereocenter

(2019) Yong-Long Zhao et al.   JOURNAL OF ORGANIC CHEMISTRY

Transition metal-free strategies for the stereoselective construction of spirocyclopropyl oxindoles

(2019) Emily P. Bacher et al.   TETRAHEDRON

Cyclopropanation of Fluorinated Sulfur Ylides with 1‐Azadienes: Facile Synthesis of CF 3 ‐Substituted Spiro Scaffolds

(2019) Tao Chen et al.   Asian Journal of Organic Chemistry

Donor–Acceptor Cyclopropanes as an Expedient Building Block Towards the Construction of Nitrogen‐Containing Molecules: An Update

(2019) Priyanka Singh et al.   ADVANCED SYNTHESIS & CATALYSIS

Development of Synthetic Methodologies via Catalytic Enantioselective Synthesis of 3,3-Disubstituted Oxindoles

(2018) Zhong-Yan Cao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Catalytic asymmetric synthesis of spirooxindoles: recent developments

(2018) Guang-Jian Mei et al.   CHEMICAL COMMUNICATIONS

Recent advances in spirocyclization of indole derivatives

(2018) Jitender Bariwal et al.   CHEMICAL SOCIETY REVIEWS

Methods for the synthesis of donor-acceptor cyclopropanes

(2018) Yu V Tomilov et al.   RUSSIAN CHEMICAL REVIEWS

Palladium-catalyzed direct C(sp3)–H arylation of indole-3-ones with aryl halides: a novel and efficient method for the synthesis of nucleophilic 2-monoarylated indole-3-ones

(2018) Yong-Long Zhao et al.   RSC Advances

Asymmetric Preparation of Polysubstituted Cyclopropanes Based on Direct Functionalization of Achiral Three-Membered Carbocycles

(2018) Longyang Dian et al.   CHEMICAL REVIEWS

PLK4 is a determinant of temozolomide sensitivity through phosphorylation of IKBKE in glioblastoma

(2018) Zuoxin Zhang et al.   CANCER LETTERS

Cycloadditions of Donor-Acceptor Cyclopropanes and Nitriles

(2017) Brian L. Pagenkopf et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Diastereo- and enantioselective [3 + 3] cycloaddition of spirocyclopropyl oxindoles using both aldonitrones and ketonitrones

(2017) Peng-Wei Xu et al.   Nature Communications

The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

(2016) Tanaji T. Talele   JOURNAL OF MEDICINAL CHEMISTRY

A Mechanistic Model for Colibactin-Induced Genotoxicity

(2016) Alan R. Healy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity

(2016) M. Palomba et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and biological evaluation of spiro[cyclopropane-1,3′-indolin]-2′-ones as potential anticancer agents

(2015) Chada Narsimha Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Spirocyclic Indolenines

(2015) Michael J. James et al.   CHEMISTRY-A EUROPEAN JOURNAL

Discovery of orally active anticancer candidate CFI-400945 derived from biologically promising spirooxindoles: Success and challenges

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 6- and 7-Membered N-Heterocycles Using α-Phenylvinylsulfonium Salts

(2015) Johnathan V. Matlock et al.   ORGANIC LETTERS

An efficient synthesis of cycloalkane-1,3-dione-2-spirocyclopropanes from 1,3-cycloalkanediones using (1-aryl-2-bromoethyl)-dimethylsulfonium bromides: application to a one-pot synthesis of tetrahydroindol-4(5H)-one

(2015) Hisanori Nambu et al.   TETRAHEDRON LETTERS

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of α-Substituted Vinylsulfonium Salts and Their Application as Annulation Reagents in the Formation of Epoxide- and Cyclopropane-Fused Heterocycles

(2014) Johnathan V. Matlock et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Asymmetric Michael–Michael Cascade for the Construction of Highly Functionalized N-Fused Piperidinoindoline Derivatives

(2014) Yong-Long Zhao et al.   ORGANIC LETTERS

1,3-Carbon D–A strategy for [3 + 2] cycloadditions/annulations with imines: synthesis of functionalized pyrrolidines and related alkaloids

(2014) Indresh Kumar   RSC Advances

Mimicking Dimethylallyltryptophan Synthase: Experimental Evidence for a Biosynthetic Cope Rearrangement Process

(2012) Darius D. Schwarzer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(II) acetate-catalyzed stereoselective synthesis, SAR and anti-HIV activity of novel oxindoles bearing cyclopropane ring

(2011) Garima Kumari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

β-(Trifluoromethyl)vinyl Sulfonium Salts: Preparation and Reactions with Active Methylene and Methenyl Compounds

(2011) Hao Lin et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Functionalized Dihydrothiophenes from Doubly Activated Cyclopropanes Using Tetrathiomolybdate as the Sulfur Transfer Reagent

(2010) Purushothaman Gopinath et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of pyrrolidin-2-ones via tandem reactions of vinyl sulfonium salts under mild conditions

(2010) Chunsong Xie et al.   TETRAHEDRON LETTERS

Recent advances in the application of bromodimethylsulfonium bromide (BDMS) in organic synthesis

(2009) Lokman H. Choudhury et al.   TETRAHEDRON

An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines, and Piperazines from β-Heteroatom Amino Compounds and Vinyl Sulfonium Salts

(2008) Muhammad Yar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION