期刊
TETRAHEDRON LETTERS
卷 56, 期 29, 页码 4312-4315出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2015.05.069
关键词
Cyclopropane; 1,3-Cyclohexanediones; Sulfonium salts; Indole; One-pot synthesis
资金
- Grants-in-Aid for Scientific Research [15K07853] Funding Source: KAKEN
An efficient synthesis of cyclohexane- and cyclopentane-1,3-dione-2-spirocyclopropanes from 1,3-cycloalkanediones using sulfonium salts was achieved. The reaction of 1,3-cycloalkanediones with (1-aryl-2-bromoethyl)-dimethylsulfonium bromides and powdered K2CO3 in EtOAc provided the corresponding spirocyclopropanes in high yields. Furthermore, a one-pot synthesis of tetrahydroindol-4(5H)-one from 1,3-cyclohexanedione was achieved using the present protocol and a sequential ring-opening cyclization of spirocyclopropane with a primary amine. (c) 2015 Elsevier Ltd. All rights reserved.
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