SIRT3‐dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

(2022) Carlos Moreno-Yruela et al.   Science Advances

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

(2022) Rui-Yuan Pan et al.   Cell Metabolism

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

(2022) Jia Xiong et al.   MOLECULAR CELL

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis

(2021) Kun Yang et al.   CELL DEATH AND DIFFERENTIATION

Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects

(2021) An-Na Chen et al.   Frontiers in Immunology

Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer

(2021) Jun Jiang et al.   Frontiers in Oncology

Histone lactylation: epigenetic mark of glycolytic switch

(2021) Xiaofeng Dai et al.   TRENDS IN GENETICS

Protein lactylation induced by neural excitation

(2021) Hideo Hagihara et al.   Cell Reports

TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation

(2020) Ricardo A. Irizarry-Caro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

(2019) Meng Li et al.   CANCER CELL

Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling

(2019) Dongyao Wang et al.   EBioMedicine

Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

(2019) Qiang Gao et al.   CELL

Histone lactylation links metabolism and gene regulation

(2019) Luke T. Izzo et al.   NATURE

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Histone Lactylation: A New Role for Glucose Metabolism

(2019) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Honokiol protects hepatocytes from oxidative injury through mitochondrial deacetylase SIRT3

(2018) Jing-Xin Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

Kinase-independent function of E-type cyclins in liver cancer

(2018) Yan Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma

(2018) Roland Sonntag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunomodulatory activity of lenvatinib contributes to antitumor activity in the Hepa1-6 hepatocellular carcinoma model

(2018) Takayuki Kimura et al.   CANCER SCIENCE

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

(2016) Aneesa Ansari et al.   AGING CELL

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer

(2014) Y Chen et al.   Cell Death & Disease

Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation

(2012) Yuan-Yuan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT3 Is a Mitochondrial Tumor Suppressor: A Scientific Tale That Connects Aberrant Cellular ROS, the Warburg Effect, and Carcinogenesis

(2012) M. C. Haigis et al.   CANCER RESEARCH

Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease

(2012) John C. Newman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low SIRT3 Expression Correlates with Poor Differentiation and Unfavorable Prognosis in Primary Hepatocellular Carcinoma

(2012) Chris Zhiyi Zhang et al.   PLoS One

Metabolic regulation by SIRT3: implications for tumorigenesis

(2012) Lydia W.S. Finley et al.   TRENDS IN MOLECULAR MEDICINE

SIRT3 and cancer: Tumor promoter or suppressor?

(2011) Turki Y. Alhazzazi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF

(2011) Paul T. Schumacker   CANCER CELL

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

(2011) Lydia W.S. Finley et al.   CANCER CELL

Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1

(2011) Peramaiyan Rajendran et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Biology of HIF-1α

(2008) A Weidemann et al.   CELL DEATH AND DIFFERENTIATION

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA