期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.688910
关键词
lactate; lactylation; macrophage; epigenetic; posttranslational modification
类别
资金
- National Natural Science Foundation of China [81772520]
- Zhejiang Provincial Natural Science Foundation [LGF19H030004]
- Zhejiang medical and health technology project [2018PY039]
Lactate is a product of glycolysis and serves as a critical energy source for mitochondrial respiration. It also acts as a precursor of gluconeogenesis and a signaling molecule. Studies have shown that lactate-mediated reprogramming of immune cells and enhancement of cellular plasticity contribute to establishing disease-specific immunity status. Further research on the relationship between lactate and histone modification is crucial for understanding disease progression and drug resistance.
Lactate is an end product of glycolysis. As a critical energy source for mitochondrial respiration, lactate also acts as a precursor of gluconeogenesis and a signaling molecule. We briefly summarize emerging concepts regarding lactate metabolism, such as the lactate shuttle, lactate homeostasis, and lactate-microenvironment interaction. Accumulating evidence indicates that lactate-mediated reprogramming of immune cells and enhancement of cellular plasticity contribute to establishing disease-specific immunity status. However, the mechanisms by which changes in lactate states influence the establishment of diverse functional adaptive states are largely uncharacterized. Posttranslational histone modifications create a code that functions as a key sensor of metabolism and are responsible for transducing metabolic changes into stable gene expression patterns. In this review, we describe the recent advances in a novel lactate-induced histone modification, histone lysine lactylation. These observations support the idea that epigenetic reprogramming-linked lactate input is related to disease state outputs, such as cancer progression and drug resistance.
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