Article
Polymer Science
Chen Wang, Qingxia Zhang, Guige Hou, Chunhua Wang, Huanhuan Yan
Summary: A multifunctional polydopamine modified core-shell nanofiber membrane loaded with antibacterial quaternary ammonium salt grafted sulfonated chitosan (QAS-SCS) and bioactive EGF/bFGF was developed for promoting wound healing. The coaxial nanofibers exhibited excellent physicochemical properties and efficient antibacterial activity. In mouse full thickness skin defect model, the multifunctional nanofibers accelerated wound healing by suppressing inflammation response, enhancing collagen deposition, promoting angiogenesis, and regenerating hair follicles.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Hassaninejad Farahani, Fatemeh Moraffah, Nasrin Samadi, Mohammad Sharifzadeh, Hamidreza Motasadizadeh, Alireza Vatanara
Summary: Lactiplantibacillus plantarum cells were encapsulated in a mixture of cationic and anionic polymers and freeze-dried, resulting in a stable composition. The effects of polymer concentrations and prebiotics on probiotic viability and swelling behavior were examined using a D-optimal design. The optimized formulation showed a viability percentage of over 82% and should be stored refrigerated. In vivo testing demonstrated improved wound healing indicators and the ability to modify wound inflammatory responses, making it comparable to silver sulfadiazine ointment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Biomedical
Yutong Yang, Yongping Liang, Jueying Chen, Xianglong Duan, Baolin Guo
Summary: This study developed a photo-crosslinked multifunctional antibacterial adhesive hemostatic hydrogel dressing that can disinfect drug-resistant bacteria and promote wound healing. Through various tests, it showed good hemostatic and antibacterial properties, and proved to be more effective than current commercially available dressings in treating infected wounds.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Puxiang Zhao, Yue Feng, Youquan Zhou, Cuiying Tan, Mingxian Liu
Summary: In this study, a wound healing hydrogel dressing with halloysite clay and chitin as the main components was prepared. The antibacterial properties, biocompatibility, and hemostatic properties of the hydrogel material were investigated. The results showed that the composite hydrogel exhibited excellent antibacterial and hemostatic activities, promoted wound healing, and had low cytotoxicity.
BIOACTIVE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Xiaohui Wei, Junjie Cai, Chunlai Wang, Kun Yang, Sheng Ding, Feng Tian
Summary: In this study, a composite sponge was prepared by combining quaternized chitosan with dialdehyde cellulose, showing good physical properties and antibacterial effects, suitable for daily wound care and emergency hemostasis treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nanoscience & Nanotechnology
Shen Guo, Yikun Ren, Rong Chang, Yuanmeng He, Dan Zhang, Fangxia Guan, Minghao Yao
Summary: An injectable hydrogel material with excellent injectability, self-healing ability, and tissue-adhesiveness was designed and fabricated. It showed antioxidative, antibacterial, and hemostatic abilities, and could effectively stop bleeding and promote wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Materials Science, Multidisciplinary
Zijian Wang, Weikang Hu, Wang Wang, Yu Xiao, Yun Chen, Xinghuan Wang
Summary: This review summarizes the impact of bacterial infection on wound healing and presents the latest advances in antibacterial nanofibrous materials for accelerating the healing process. By incorporating substances such as antibiotics, antimicrobial peptides, metals, and antibacterial polymers into ENMs, the antibacterial activity of ENMs is enhanced.
ADVANCED FIBER MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Parinaz Nezhad-Mokhtari, Fahimeh Kazeminava, Bahman Abdollahi, Pourya Gholizadeh, Abolfazl Heydari, Faranak Elmi, Mahmoud Abbaszadeh, Hossein Samadi Kafil
Summary: Recently, researchers have developed antibacterial wound dressings based on biomaterials that have shown good biocompatibility and the potential to accelerate wound healing. In this study, eco-friendly and biodegradable nanofibers were prepared by incorporating zeolite imidazolate framework nanoparticles and chamomile essential oil into a chitosan/ poly (& epsilon;-caprolactone) matrix using the electrospinning technique. The fabricated nanofibers demonstrated excellent cytocompatibility, proliferation, and antibacterial activity against common wound pathogens.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Quanhong Hu, Xingyi Wan, Shaobo Wang, Tian Huang, Xinyang Zhao, Chuyu Tang, Minjia Zheng, Xueyu Wang, Linlin Li
Summary: This study successfully constructed a Janus nanofiber dressing with comprehensive functions of bacterial killing, piezoelectric stimulation to promote fibroblast migration, and unidirectional liquid delivery for wound exudate removal. The Janus dressing, fabricated through layer-by-layer electrostatic spinning technology, exhibits ultrathin, flexible, breathable, and piezoelectric characteristics. Experimental results indicate that the Janus dressing not only drains excess wound exudate and kills local bacteria, but also generates dynamic piezopotential to accelerate wound healing on mice through fibroblast proliferation and migration, collagen deposition, angiogenesis, and re-epithelialization.
SCIENCE CHINA-MATERIALS
(2023)
Article
Chemistry, Physical
Weiwang Qiu, Hua Han, Mengna Li, Na Li, Qian Wang, Xiaohong Qin, Xueli Wang, Jianyong Yu, Yunxia Zhou, Yan Li, Faxue Li, Dequn Wu
Summary: The peptide modified nanofibers reinforced hydrogel designed by Schiff base dynamic crosslinking not only maintains a healthy wound microenvironment, but also greatly enhances the stability and mechanical strength of the hydrogel.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Haofeng Hu, Fulin Luo, Qian Zhang, Ming Xu, Xin Chen, Zhihao Liu, Haodong Xu, Lei Wang, Fei Ye, Kui Zhang, Bin Chen, Song Zheng, Jia Jin
Summary: A novel dressing with both hemostatic and antibacterial capability was developed and studied in this work. The results showed that the hemostatic and antibacterial activities were significantly enhanced through the calcium/berberine dual-crosslinking system. The dressing demonstrated better clotting and wound healing performance than commercial dressing in animal models, and showed excellent bacteriostatic activity and biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Zongbao Zhou, Jiangwei Xiao, Shuwen Guan, Zhijie Geng, Ruifang Zhao, Botao Gao
Summary: A curdlan-tannic acid hybrid hydrogel was successfully fabricated through the annealing technique, which exhibited excellent physicochemical properties and showed no significant cytotoxicity to cells. In vivo experiments proved that the multifunctional hydrogel could accelerate wound healing.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Miao Xu, Xiaohuan Ji, Jingjing Huo, Jingjie Chen, Nian Liu, Ziyue Li, Qingyan Jia, Bin Sun, Meifang Zhu, Peng Li
Summary: In this study, AgNPs were modified and embedded into CA hydrogel to create a multifunctional material for wound healing. The CA/Ag hydrogel exhibited on-demand photodynamic antibacterial efficacy and effective hemostatic ability. Furthermore, it promoted wound healing by downregulating proinflammatory cytokines. Overall, the CA/Ag nanocomposite hydrogel has excellent prospects as an advanced wound dressing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Xiaofang Chen, Yaqin Chen, Bofei Fu, Kunjie Li, Donghong Huang, Chaohui Zheng, Minghuan Liu, Da-Peng Yang
Summary: In this study, CuS nanoparticles were prepared using eggshell membranes as templates and a multifunctional nanofibrous membrane was synthesized. The nanofiber membrane exhibited antibacterial, hemostatic, and wound healing properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Environmental
Jiaxin Wang, Jiahui He, Yutong Yang, Xianzhen Jin, Juntang Li, Baolin Guo
Summary: In this study, GVG-Zn cryogels were successfully prepared by combining methacrylic anhydride-modified gelatin, beta-cyclo-dextrin modified reduced graphene oxide, 1-vinylimidazole, and zin ion. The cryogels exhibited enhanced mechanical strength, fatigue resistance, inter-connected porous structure, rapid expansion property, conductivity, biocompatibility, and photothermal antibacterial properties. They also showed excellent hemostasis and promoted wound healing.
CHEMICAL ENGINEERING JOURNAL
(2024)
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)