A hydrogen-bonded antibacterial curdlan-tannic acid hydrogel with an antioxidant and hemostatic function for wound healing

Manufacturing facile and low-cost wound dressings that simultaneously meet the needs of the entire repair process remains the major challenge of effective wound healing. Herein, a series of curdlan-tannic acid hybrid hydrogels were successfully fabricated through the annealing technique. Notedly, when the mixing weigh ratio was 1:1, the hydrogel exhibited excellent physicochemical properties, including swellability, degradability, water retention, porosity, and rheology. Additionally, the hydrogel did not display significant cytotoxicity to fibroblasts and the hemolysis rate at 12 h was 3%. Interestingly, the hybrid hydrogel showed multifunctional properties, including remarkable antioxidant, antibacterial, and rapid hemostasis effects reduce blood loss by 0.35 g, that were achieved through the temperature-dependent release of tannic acid. Moreover, a full-thickness skin defect animal model was used to verify that the multifunctional hydrogel could accelerate wound healing in vivo. These results suggest that this hybrid hydrogel is a promising candidate for the clinical treatment of fullthickness wounds.

Automated summary

A curdlan-tannic acid hybrid hydrogel was successfully fabricated through the annealing technique, which exhibited excellent physicochemical properties and showed no significant cytotoxicity to cells. In vivo experiments proved that the multifunctional hydrogel could accelerate wound healing.