期刊
ACS APPLIED MATERIALS & INTERFACES
卷 14, 期 30, 页码 34455-34469出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c08870
关键词
multifunctional wound dressing; injectable; self-healing; tissue adhesiveness; antioxidant; antibacterial; hemostasis; wound healing
资金
- National Natural Science Foundation of China [U1804198]
- Key R&D and Promotion Projects in Henan Province [212102310233]
- M.Y., Zhongyuan Thousand Talents Project [204200510013]
- Discipline Innovation and Wisdom Introduction Plan of Higher Education in Henan Province [CXJD2021002]
An injectable hydrogel material with excellent injectability, self-healing ability, and tissue-adhesiveness was designed and fabricated. It showed antioxidative, antibacterial, and hemostatic abilities, and could effectively stop bleeding and promote wound healing.
Engineered wound dressing materials with excellent injectability, self-healing ability, tissue-adhesiveness, especially the ones possessing potential therapeutic effects have great practical significance in healthcare. Herein, an injectable quaternary ammonium chitosan (QCS)/tannic acid (TA) hydrogel based on QCS and TA was designed and fabricated by facile mixing of the two ingredients under physiological conditions. In this system, hydrogels were mainly cross-linked by dynamic ionic bonds and hydrogen bonds between QCS and TA, which endows the hydrogel with excellent injectable, self-healing, and adhesive properties. Benefitting from the inherent antioxidative, antibacterial, and hemostatic abilities of TA and QCS, this hydrogel showed superior reactive oxygen species scavenging activity, broad-spectrum antibacterial ability, as well as rapid hemostatic capability. Moreover, the QCS/TA(2.5) hydrogel (containing 2.5% TA) exhibited excellent biocompatibility. The in vivo experiments also showed that QCS/TA(2.5) hydrogel dressing not only rapidly stopped the bleeding of arterial and deep incompressible wounds in mouse tail amputation, femoral artery hemorrhage, and liver incision models but also significantly accelerated wound healing in a full-thickness skin wound model. For the great potentials listed above, this multifunctional QCS/TA(2.5) hydrogel offers a promising network as a dressing material for both rapid hemostasis and skin wound repair.
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