Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

PI3-kinase deletion promotes myelodysplasia by dysregulating autophagy in hematopoietic stem cells

(2023) Kristina Ames et al.   Science Advances

PLAG1 dampens protein synthesis to promote human hematopoietic stem cell self-renewal

(2022) Ava Keyvani Chahi et al.   BLOOD

Chaperone-mediated autophagy sustains haematopoietic stem-cell function

(2021) Shuxian Dong et al.   NATURE

Essential role of autophagy in protecting neonatal haematopoietic stem cells from oxidative stress in a p62-independent manner

(2021) Naho Nomura et al.   Scientific Reports

Developmental Stage-Specific Changes in Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells and Erythroid Progenitors to Impaired Ribosome Biogenesis

(2021) Jeffrey A. Magee et al.   Stem Cell Reports

TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate

(2021) Laura García-Prat et al.   Cell Stem Cell

Hsf1 promotes hematopoietic stem cell fitness and proteostasis in response to ex vivo culture stress and aging

(2021) Miriama Kruta et al.   Cell Stem Cell

Simplified murine multipotent progenitor isolation scheme: Establishing a consensus approach for multipotent progenitor identification

(2021) Grant A. Challen et al.   EXPERIMENTAL HEMATOLOGY

Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells

(2020) Bernadette A. Chua et al.   Cell Stem Cell

Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit

(2020) Christopher S. Morrow et al.   Cell Stem Cell

Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency

(2020) Raymond Liang et al.   Cell Stem Cell

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal

(2020) Lorena Hidalgo San Jose et al.   Cell Reports

Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells

(2019) Dirk Loeffler et al.   NATURE

Sphingolipid Modulation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal

(2019) Stephanie Z. Xie et al.   Cell Stem Cell

Regulation of LC3B levels by ubiquitination and proteasomal degradation

(2019) Rui Jia et al.   Autophagy

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

(2018) Dena S. Leeman et al.   SCIENCE

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy

(2017) Xi Fang et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Autophagy is a signature of a signaling network that maintains hematopoietic stem cells

(2017) Michelle Nguyen-McCarty et al.   PLoS One

A thiol probe for measuring unfolded protein load and proteostasis in cells

(2017) Moore Z. Chen et al.   Nature Communications

Phosphorylation of eIF2α Is a Translational Control Mechanism Regulating Muscle Stem Cell Quiescence and Self-Renewal

(2016) Victoria Zismanov et al.   Cell Stem Cell

Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation

(2016) Carlos G. Sanchez et al.   Cell Stem Cell

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

(2016) Robert A.J. Signer et al.   GENES & DEVELOPMENT

Stem cell function and stress response are controlled by protein synthesis

(2016) Sandra Blanco et al.   NATURE

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

(2015) Enric Llorens-Bobadilla et al.   Cell Stem Cell

HspB8 and Bag3: A new chaperone complex targeting misfolded proteins to macroautophagy

(2014) Serena Carra et al.   Autophagy

Fluorescent dye ProteoStat to detect and discriminate intracellular amyloid-like aggregates inEscherichia coli

(2014) Susanna Navarro et al.   Biotechnology Journal

IL-7 Specifies B Cell Fate at the Common Lymphoid Progenitor to Pre-ProB Transition Stage by Maintaining Early B Cell Factor Expression

(2014) K. Kikuchi et al.   JOURNAL OF IMMUNOLOGY

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

(2014) Peter van Galen et al.   NATURE

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

A novel crosstalk between two major protein degradation systems

(2013) Xiao J Wang et al.   Autophagy

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mechanisms that Regulate Stem Cell Aging and Life Span

(2013) Robert A.J. Signer et al.   Cell Stem Cell

SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

(2013) Hideyuki Oguro et al.   Cell Stem Cell

New Autophagy Reporter Mice Reveal Dynamics of Proximal Tubular Autophagy

(2013) L. Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

FOXO3A directs a protective autophagy program in haematopoietic stem cells

(2013) Matthew R. Warr et al.   NATURE

The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment

(2013) Elisa Laurenti et al.   NATURE IMMUNOLOGY

Proteostasis and aging of stem cells

(2013) David Vilchez et al.   TRENDS IN CELL BIOLOGY

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

(2012) Lyndsay Murrow et al.   Annual Review of Pathology-Mechanisms of Disease

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

(2012) Maria Carolina Florian et al.   Cell Stem Cell

Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition

(2012) Amila Suraweera et al.   MOLECULAR CELL

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

(2012) David Vilchez et al.   NATURE

Quality control and preprocessing of metagenomic datasets

(2011) R. Schmieder et al.   BIOINFORMATICS

Bortezomib as the First Proteasome Inhibitor Anticancer Drug: Current Status and Future Perspectives

(2011) D. Chen et al.   CURRENT CANCER DRUG TARGETS

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

(2011) Monika Mortensen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases

(2011) K. Seidel et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells

(2010) F. Liu et al.   BLOOD

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Intracellular Protein Aggregation Is a Proximal Trigger of Cardiomyocyte Autophagy

(2008) Paul Tannous et al.   CIRCULATION

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE