Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study

FinnGen provides genetic insights from a well-phenotyped isolated population

(2023) Mitja I. Kurki et al.   NATURE

Cancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes

(2022) Nick Lung-Ngai Ting et al.   GUT

Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study

(2022) Daniela Mariosa et al.   JNCI-Journal of the National Cancer Institute

Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene–environment interactions across the lifespan

(2022) Alvar Agustí et al.   Lancet Respiratory Medicine

The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants

(2021) Anders B. Dohlman et al.   Cell Host & Microbe

Large-scale association analyses identify host factors influencing human gut microbiome composition

(2021) Alexander Kurilshikov et al.   NATURE GENETICS

Mendelian randomisation for mediation analysis: current methods and challenges for implementation

(2021) Alice R. Carter et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Profiling of tumour-associated microbiota in human hepatocellular carcinoma

(2021) Seiga Komiyama et al.   Scientific Reports

Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans

(2021) Omar Delannoy-Bruno et al.   NATURE

Gut microbiota diversity after autologous fecal microbiota transfer in acute myeloid leukemia patients

(2021) Florent Malard et al.   Nature Communications

The Cancer Microbiome: Recent Highlights and Knowledge Gaps

(2021) Reece J. Knippel et al.   Cancer Discovery

Causal Effects of Gut Microbiome on Systemic Lupus Erythematosus: A Two-Sample Mendelian Randomization Study

(2021) Kun Xiang et al.   Frontiers in Immunology

Gut microbiota modulates weight gain in mice after discontinued smoke exposure

(2021) Leviel Fluhr et al.   NATURE

Cancer induces a stress ileopathy depending on B-adrenergic receptors and promoting dysbiosis that contribute to carcinogenesis

(2021) Satoru Yonekura et al.   Cancer Discovery

Microbiome and Gastric Cancer

(2020) Lars Engstrand et al.   DIGESTIVE DISEASES AND SCIENCES

Gut microbiome associations with breast cancer risk factors and tumor characteristics: a pilot study

(2020) Anna H. Wu et al.   BREAST CANCER RESEARCH AND TREATMENT

A genome-wide association study identifies two novel susceptible regions for squamous cell carcinoma of the head and neck

(2020) Sanjay Shete et al.   CANCER RESEARCH

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

(2020) Haoyu Zhang et al.   NATURE GENETICS

Diet and cancer risk reduction: The role of diet-microbiota interactions and microbial metabolites

(2020) Tiffany L. Weir et al.   SEMINARS IN CANCER BIOLOGY

Targeting gut microbiota with dietary components on cancer: Effects and potential mechanisms of action

(2019) Jun Tao et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Effects of dietary fat on gut microbiota and faecal metabolites, and their relationship with cardiometabolic risk factors: a 6-month randomised controlled-feeding trial

(2019) Yi Wan et al.   GUT

Characterization of gut microbiota, bile acid metabolism, and cytokines in intrahepatic cholangiocarcinoma

(2019) Xiaodong Jia et al.   HEPATOLOGY

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

(2019) Shinichi Yachida et al.   NATURE MEDICINE

Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn’s disease, produces an inflammatory polysaccharide

(2019) Matthew T. Henke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer

(2019) Mingyang Song et al.   GASTROENTEROLOGY

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

(2018) Fredrick R. Schumacher et al.   NATURE GENETICS

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression

(2018) Smruti Pushalkar et al.   Cancer Discovery

The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get

(2018) Jia Yang et al.   Protein & Cell

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative

(2018) Jun Wang et al.   Microbiome

Modified penetrance of coding variants by cis-regulatory variation contributes to disease risk

(2018) Stephane E. Castel et al.   NATURE GENETICS

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

(2017) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

(2017) Catherine M Phelan et al.   NATURE GENETICS

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Orienting the causal relationship between imprecisely measured traits using GWAS summary data

(2017) Gibran Hemani et al.   PLoS Genetics

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Mendelian Randomization as an Approach to Assess Causality Using Observational Data

(2016) P. Sekula et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases

(2016) Rong Chen et al.   NATURE BIOTECHNOLOGY

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

A review of instrumental variable estimators for Mendelian randomization

(2015) Stephen Burgess et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome

(2015) Fabiola Del Greco M et al.   STATISTICS IN MEDICINE

Unique Organization of Extracellular Amylases into Amylosomes in the Resistant Starch-Utilizing Human Colonic Firmicutes Bacterium Ruminococcus bromii

(2015) Xiaolei Ze et al.   mBio

Ten-Year Trends in Fiber and Whole Grain Intakes and Food Sources for the United States Population: National Health and Nutrition Examination Survey 2001–2010

(2015) Carla McGill et al.   Nutrients

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Altered Tissue Metabolites Correlate with Microbial Dysbiosis in Colorectal Adenomas

(2014) Julia L. Nugent et al.   JOURNAL OF PROTEOME RESEARCH

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

(2014) Krishnan Bhaskaran et al.   LANCET

Challenges to effective cancer control in China, India, and Russia

(2014) Paul E Goss et al.   LANCET ONCOLOGY

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

(2014) Manon D. Schulz et al.   NATURE

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer

(2014) Yufei Wang et al.   NATURE GENETICS

Genetic susceptibility testing and readiness to control weight: Results from a randomized controlled trial

(2014) Susanne F. Meisel et al.   Obesity

Gut microbiome of the Hadza hunter-gatherers

(2014) Stephanie L. Schnorr et al.   Nature Communications

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans

(2012) Nina Sanapareddy et al.   ISME Journal

Design and coverage of high throughput genotyping arrays optimized for individuals of East Asian, African American, and Latino race/ethnicity using imputation and a novel hybrid SNP selection algorithm

(2011) Thomas J. Hoffmann et al.   GENOMICS

Health and economic burden of the projected obesity trends in the USA and the UK

(2011) Y Claire Wang et al.   LANCET

Psychological Responses to Genetic Testing for Weight Gain: A Vignette Study

(2011) Susanne F. Meisel et al.   Obesity

Bias in causal estimates from Mendelian randomization studies with weak instruments

(2011) Stephen Burgess et al.   STATISTICS IN MEDICINE

Genome-wide association studies in diverse populations

(2010) Noah A. Rosenberg et al.   NATURE REVIEWS GENETICS

Site and Clinical Significance of Alloscardovia omnicolens and Bifidobacterium Species Isolated in the Clinical Laboratory

(2009) S. D. Mahlen et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Genetic Mapping in Human Disease

(2008) D. Altshuler et al.   SCIENCE