Article
Multidisciplinary Sciences
Yunjia Lai, Chih-Wei Liu, Yifei Yang, Yun-Chung Hsiao, Hongyu Ru, Kun Lu
Summary: Microbiota plays a significant role in regulating the metabolites in feces, blood serum, and brain tissues, impacting various pathways including aromatic amino acids and neurotransmitters. The study highlights microbiota-derived metabolites potentially involved in interorgan transport and the gut-brain axis, with specific gender characteristics discussed.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Katie Meyer, Anju Lulla, Kunal Debroy, James M. Shikany, Kristine Yaffe, Osorio Meirelles, Lenore J. Launer
Summary: This study found associations between gut microbial composition and cognitive measures in middle-aged adults, suggesting a potential link between gut microbiota and cognitive aging that warrants further research and validation in larger samples.
Review
Nutrition & Dietetics
Emily A. Losno, Katharina Sieferle, Federico J. Armando Perez-Cueto, Christian Ritz
Summary: The human gut microbiota play a crucial role in health and are influenced by dietary habits. Vegan diets may impact the diverse ecosystem of beneficial bacteria in the gut. Studies on vegans suggest changes in gut microbiota composition, but complexities in evaluating results and the need for more randomized controlled trials are highlighted.
Review
Biochemistry & Molecular Biology
Piero Portincasa, Leonilde Bonfrate, Mirco Vacca, Maria De Angelis, Ilaria Farella, Elisa Lanza, Mohamad Khalil, David Q. -H. Wang, Markus Sperandio, Agostino Di Ciaula
Summary: The gut microbiota consists of trillions of commensal microorganisms including bacteria, fungi, and viruses, which coexist in symbiosis with the host and have profound effects on human health. Short chain fatty acids (SCFAs) are the most abundant bacterial metabolites in the human body and play an important role in metabolic, endocrine, and immune functions. Diet can influence the composition and activity of the gut microbiota, as well as SCFAs production and metabolic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Nurkhalida Kamal, Muna Abdulsalam Ilowefah, Ayah Rebhi Hilles, Nurul Adlina Anua, Tahani Awin, Hussah Abdullah Alshwyeh, Sahar Khamees Aldosary, Najla Gooda Sahib Jambocus, Areej A. Alosaimi, Azizur Rahman, Syed Mahmood, Ahmed Mediani
Summary: Cancer is a major disease with a high mortality rate globally, and unhealthy lifestyle and poor dietary habits are key risk factors. High fruit and vegetable intake in diet may effectively reduce the risk of developing certain types of cancers.
Article
Multidisciplinary Sciences
David K. Jacobson, Tanvi P. Honap, Andrew T. Ozga, Nicolas Meda, Therese S. Kagone, Helene Carabin, Paul Spicer, Raul Y. Tito, Alexandra J. Obregon-Tito, Luis Marin Reyes, Luzmila Troncoso-Corzo, Emilio Guija-Poma, Krithivasan Sankaranarayanan, Cecil M. Lewis
Summary: The study found that non-industrial populations have higher genus-level resilience in their gut microbiomes, while industrial populations have low resilience potential in SCFA production, driven by a few phylogenetically closely related species. Additionally, database biases affect resilience estimates, with a higher likelihood of identifying SCFA-encoding species in industrial microbiomes compared to non-industrial populations. Overall, non-industrial gut microbiomes show high phylogenetic diversity, richness, and evenness in bacteria encoding SCFAs, indicating high potential for resilience in SCFA production.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Peng Cheng, Jiawei Wu, Gangfan Zong, Feihui Wang, Rui Deng, Ruizhi Tao, Cheng Qian, Yunlong Shan, Aiyun Wang, Yang Zhao, Zhonghong Wei, Yin Lu
Summary: Dietary factors play a vital role in tumorigenesis. The effect of a spicy diet on cancer development, particularly colon cancer metastasis, has been controversial. In this study, a mouse metastasis model was used to investigate the role of capsaicin in metastasis. The long-term administration of capsaicin diet (300 mg/kg) in mice promoted the formation of a liver pre-metastatic niche, facilitating the metastasis of colon cancer cells. Bacteria translocation to the liver was observed, and capsaicin altered the composition of gut microbiota, increasing intestinal barrier permeability and disrupting the gut vascular barrier. The dysregulated bile acids profile affected the recruitment of natural killer T (NKT) cells in the pre-metastatic niche, with primary bile acid alpha-Muricholic acid enhancing NKT cell recruitment and secondary bile acids Glycoursodeoxycholic acid and Taur-ohyodeoxycholic acid impairing NKT cell recruitment. These findings highlight the increased risk of cancer metastasis through gut microbiota modulation caused by long-term consumption of capsaicin.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Maria Teresa Rocchetti, Francesco Bellanti, Mariia Zadorozhna, Daniela Fiocco, Domenica Mangieri
Summary: Luteolin is a flavonoid derived from plants and fruits, and it has been used in Asian medicine for centuries to treat various human diseases. It exhibits anti-inflammatory, antioxidant, immunomodulatory properties, and also shows anti-cancer/anti-metastatic effects. This review aims to explore the mechanisms by which luteolin inhibits tumor progression in metastasis, including affecting EMT, repressing angiogenesis and lysis of ECM, as well as inducing apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Ling Lu, Bei Chen, XinYi Zhang, Yumeng Xu, Longtao Jin, Hui Qian, Zhao feng Liang
Summary: Gastric cancer is a common malignant tumor with a low early diagnosis rate, and N-methyl-N-nitro-N-nitroguanidine (MNNG) is one of the main risk factors. Phytochemicals derived from plants have promising effects in preventing and treating gastric cancer induced by MNNG. Multiple studies have shown that phytochemicals can protect against MNNG-induced gastric cancer by inhibiting cell proliferation, enhancing immunity, suppressing invasion and migration, inducing apoptosis and autophagy, blocking angiogenesis, inhibiting H. pylori infection, and regulating metabolism and microbiota. Understanding the intervention and therapeutic effects of phytochemicals in MNNG-induced gastric cancer is of great importance.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Francesca Celiberto, Adriana Aloisio, Bruna Girardi, Maria Pricci, Andrea Iannone, Francesco Russo, Giuseppe Riezzo, Benedetta D'Attoma, Enzo Ierardi, Giuseppe Losurdo, Alfredo Di Leo
Summary: Colorectal cancer is a major cause of cancer-related deaths in developed countries and is strongly influenced by dietary habits. Inadequate fiber intake in Western countries may contribute to the increased incidence of colorectal cancer. Daily fiber intake has been inversely associated with the risk of colorectal cancer, and dietary interventions based on high-fiber diets have shown promising results in preventing the development of this type of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ana Dacil Marrero, Ana R. Quesada, Beatriz Martinez-Poveda, Miguel Angel Medina
Summary: Despite our extensive knowledge of cancer, the high incidence of the disease necessitates new approaches to complement clinical tumor intervention. Interestingly, many cancers are closely tied to dietary habits associated with the Western lifestyle, such as low fruit and vegetable intake. Recent advances in the concept of chemoprevention highlight the role of phytochemicals as potential candidates for cancer prevention or treatment, due to their ability to inhibit angiogenesis. This review focuses on the antitumoral potential of phenolic and polyphenolic compounds, terpenoids, and anthraquinones from Aloe vera, with a particular emphasis on their antiangiogenic effects, based on in vitro and in vivo assays, as well as available clinical data. Although clinical trials have not fully evaluated the preventive role of these compounds, promising preclinical data support the effectiveness of dietary phytochemicals in cancer prevention and treatment, with a need for a deeper understanding of their mechanisms of action and better designed clinical trials.
Article
Medicine, Research & Experimental
Katya Frazier, Sumeed Manzoor, Katherine Carroll, Orlando Deleon, Sawako Miyoshi, Jun Miyoshi, Marissa St. George, Alan Tan, Evan A. Chrisler, Mariko Izumo, Joseph S. Takahashi, Mrinalini C. Rao, Vanessa A. Leone, Eugene B. Chang
Summary: There is hierarchical, bidirectional communication between gut microbes and the liver circadian clock, with the liver clock relying on gut microbes to regulate glucose and lipid metabolism.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Nutrition & Dietetics
Sandeep Appunni, Muni Rubens, Venkataraghavan Ramamoorthy, Raees Tonse, Anshul Saxena, Peter McGranaghan, Adeel Kaiser, Rupesh Kotecha
Summary: Dietary factors play a crucial role in modulating gut microbiota and restoring colonic epithelium. A healthy plant-based diet and related supplements are essential in preventing CRC by improving the gut microbiome. Dietary and lifestyle modifications can restrict the growth of harmful organisms.
FRONTIERS IN NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Min Chen, Shizhao Li, Itika Arora, Nengjun Yi, Manvi Sharma, Zhenhai Li, Trygve O. Tollefsbol, Yuanyuan Li
Summary: This study aimed to investigate the effects of maternal exposure to genistein (GE), a natural isoflavone enriched in soybean products, on the prevention of overnutrition-induced breast cancer later in life. The results showed that maternal dietary GE treatment improved metabolic functions and delayed mammary tumor development in offspring mice. The study suggested that maternal GE consumption could effectively intervene in early-life obesity-related metabolic disorders and breast cancer by influencing the interplay between early-life gut microbiota, microbial metabolite profiles, and offspring epigenome.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Nutrition & Dietetics
Jesus Rodriguez-Molinero, Blanca del Carmen Miguelanez-Medran, Cristina Puente-Gutierrez, Esther Delgado-Somolinos, Carmen Martin Carreras-Presas, Javier Fernandez-Farhall, Antonio Francisco Lopez-Sanchez
Summary: Oral cancer, the sixth most common malignant neoplasm in the world, is mainly caused by tobacco and alcohol, with diet also considered an important factor. Some dietary nutrients, such as fruits, vegetables, curcumin, and green tea, have anti-cancer effects, while a diet rich in red meat and fried foods may increase the risk. Research suggests that a diet rich in vegetables and fruits can have preventive effects against oral and other types of cancer.
Review
Food Science & Technology
Gopalsamy Rajiv Gandhi, Varghese Edwin Hillary, Poovathumkal James Antony, Linda L. D. Zhong, Devarajan Yogesh, Neenthamadathil Mohandas Krishnakumar, Stanislaus Antony Ceasar, Ren-You Gan
Summary: Type 2 diabetes mellitus (T2DM) is a metabolic syndrome characterized by dysfunction of pancreatic beta-cells due to genetic and environmental factors. Essential oils derived from dietary plants have been found to have anti-diabetic effects by modulating specific signaling pathways and inflammatory mediators involved in insulin resistance.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Jiani Yang, Ting Gu, Yongtong Lu, Yuejia Xu, Ren-You Gan, Siew Bee Ng, Quancai Sun, Ye Peng
Summary: Osmanthus fragrans, a traditional fragrant plant cultivated in China for over 2,500 years, has gained increasing attention due to its unique aroma and potential health benefits. This review summarizes the aroma and functional components of O. fragrans, discusses their biosynthetic mechanism, and highlights the beneficial functions and related molecular mechanism of O. fragrans extract. Potential applications and future perspectives are also summarized and discussed. Based on current research, O. fragrans extracts and components have great potential to be developed into value-added functional ingredients with preventive effects on certain chronic diseases. However, efficient, large-scale, and commercially viable extraction methods are crucial, along with more clinical studies to explore its beneficial functions and guide its development into functional food products.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Chen Liu, Ren-You Gan, Daiwen Chen, Liang Zheng, Siew Bee Ng, Ivonne M. C. M. Rietjens
Summary: Green tea catechins (GTCs) have various beneficial effects, but their bioavailability is generally low. The majority of ingested GTCs are degraded by gut microbiota, forming low-molecular-weight metabolites. This process improves the bioavailability and enriches the biological activities of GTCs.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Lejaniya Abdul Kalam Saleena, Pui Liew Phing, Ren-You Gan, Anas Al-Nabulsi, Tareq Osaili, Afaf Kamal-Eldin, Mutamed Ayyash
Summary: Fermented dairy products like yogurt and kefir are popular in the MENA region for their unique flavor and potential health benefits. However, traditional production methods lack consistency, making standardization and quality assurance challenging. Despite this, these products are believed to have significant health benefits due to traditional processing methods.
INTERNATIONAL DAIRY JOURNAL
(2023)
Article
Food Science & Technology
Ming-Yue Li, Yi Liu, Kin Weng Kong, Fang Geng, Hong-Yan Liu, Ren-You Gan
Summary: In this study, different cultivars of broccoli seeds and sprouts were investigated for their metabolites, antioxidant properties, total phenolic content (TPC), and total flavonoid content (TFC). The sprouts of Lv Hua (LH), You Xiu (YX), and Bi Lv (BL) had significant differences in metabolites compared to their respective seeds. The linoleic acid metabolism pathway was found to be significant in all three cultivars. Overall, this study provides scientific support for the selection of broccoli cultivars for germination and product development.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Huan Guo, Yin-Jian Zheng, Ding-Tao Wu, Xu Du, Hong Gao, Mutamed Ayyash, De-Guang Zeng, Hua-Bin Li, Hong-Yan Liu, Ren-You Gan
Summary: China is a major producer of citrus fruits, and Sichuan is one of the major citrus planting bases with a large citrus planting area. However, there is limited information on the functional, nutritional, and qualitative characteristics of different citrus varieties in Sichuan. This study systematically investigated and analyzed 10 typical citrus varieties cultivated in Sichuan, and found significant differences among the varieties in terms of quality attributes, juice properties, mineral elements, and health-promoting nutritional and functional components. The results provide valuable information for the cultivation and selection of nutritious citrus fruits.
FRONTIERS IN NUTRITION
(2023)
Review
Food Science & Technology
Huan Guo, Hong-Yan Liu, Hang Li, Ding-Tao Wu, Linda L. D. Zhong, Ren-You Gan, Hong Gao
Summary: This study discusses and compares the effects of different drying processes on the chemical composition, structural, and biological properties of plant polysaccharides. It also emphasizes that the biological properties of polysaccharides are determined by multiple factors, providing a fundamental theoretical basis for the structure-function relationship of these compounds.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Applied
Hongyan Liu, Jing Nie, Yi Liu, Syed Abdul Wadood, Karyne M. Rogers, Yuwei Yuan, Ren-You Gan
Summary: Compound-specific stable isotope analysis (CSIA) is a new technique used to authenticate and detect adulteration in food products. This paper provides a review of recent applications of CSIA in various food categories, such as plant and animal origin foods, essential oils, and plant extracts. The study discusses different techniques, applications, and recent studies, highlighting the analytical advantages of CSIA for food authentication.
Article
Chemistry, Applied
Abdelmoneim H. Ali, Salah A. Kalifa, Ren-You Gan, Nagendra Shah, Mutamed Ayyash
Summary: The fatty acid and amino acid composition of ripened and unripened cheeses produced from different milk sources were investigated in this study. Major fatty acids detected in the cheeses were myristic, palmitic, stearic, and oleic. Each cheese type had a distinctive amino acid profile. These findings have important implications for the dairy industry and food composition analysis.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Ruo-Gu Xiong, Si-Xia Wu, Jin Cheng, Adila Saimaiti, Qing Liu, Ao Shang, Dan-Dan Zhou, Si-Yu Huang, Ren-You Gan, Hua-Bin Li
Summary: This paper explores the production of two novel kombucha beverages with bamboo leaf or mulberry leaf, and compares the effects of fermentation with or without leaf residues on the antioxidant properties of kombucha. The results show that both types of kombucha have high antioxidant capacities, while kombucha fermented with bamboo leaf residues significantly enhances its antioxidant capabilities, total phenolic content, concentrations of some compounds, and sensory acceptability. Fermentation with leaf residues has no significant effect on mulberry leaf kombucha.
Review
Food Science & Technology
Ding-Tao Wu, Wen-Xing Li, Jia-Jia Wan, Yi-Chen Hu, Ren-You Gan, Liang Zou
Summary: This review summarizes the literature from the last ten years regarding the chemical composition, physicochemical properties, processing, health benefits, and potential applications of pea. The pea and its components can be further developed into more valuable and nutritious products.
Article
Food Science & Technology
Si-Xia Wu, Ruo-Gu Xiong, Jin Cheng, Xiao-Yu Xu, Guo-Yi Tang, Si-Yu Huang, Dan-Dan Zhou, Adila Saimaiti, Ren-You Gan, Hua-Bin Li
Summary: In this study, kombucha beverages were prepared using golden-flower tea and honeysuckle-flower tea as raw materials. The antioxidant activities, total phenolic contents, concentrations of bioactive components, and sensory scores of the kombucha beverages were assessed. The results showed that both kombucha beverages had strong antioxidant activities and high sensory analysis scores. Fermentation with golden-flower tea residues significantly increased the antioxidant activity and total phenolic contents, while fermentation with honeysuckle tea residues had a minor effect. The concentrations of bioactive compounds could be increased by fermentation with golden-flower tea residues, but fermentation with honeysuckle-flower tea residues had limited effects. The sensory scores of golden-flower tea kombucha and honeysuckle-flower tea kombucha were not significantly affected by fermentation with or without tea residues, and golden-flower tea kombucha had higher sensory scores.
Review
Food Science & Technology
Weicheng Li, Qiong Wu, Lai-yu Kwok, Heping Zhang, Renyou Gan, Zhihong Sun
Summary: This review summarizes the research progress of the population and functional genomics of lactic acid bacteria (LAB). It elucidates the formation mechanism and driving forces of LAB characteristics, highlights the application of LAB genome in food safety and properties, and provides suggestions for improving resource exploitation and application.
Article
Energy & Fuels
Pengfei Yao, Xiaohua Jiang
Summary: This paper analyzes harmonic distortion caused by the narrow pulse problem in matrix converters and proposes an improved switching pattern based on the basic five vector switching pattern. The improved pattern solves the narrow pulse problem by adding an additional zero vector and adjusting the sequence of the four active vectors to minimize switching times. Simulation and experimental results show that the proposed six vector switching pattern reduces low-frequency harmonics, decreases average switching frequency, attenuates sampling frequency harmonics, improves the THD of the output current, and has benefits in both normal and unbalanced input voltage conditions.
CSEE JOURNAL OF POWER AND ENERGY SYSTEMS
(2023)
Article
Engineering, Biomedical
Chunyan Fang, Yaodong You, Fan Luo, Zheng Li, Yifeng Shen, Fangyue Wang, Jingyi Zhang, Ren-You Gan, Yulong Ye
Summary: In this study, a novel drug delivery system (ICA-SNPs) was developed using natural silk fibroin nanoparticles to load icariin (ICA). The system effectively delivered drugs to spermatogonium, enhancing the anti-infertility properties of ICA and mitigating spermatogenesis dysfunction induced by BPA.
ADVANCED HEALTHCARE MATERIALS
(2023)