4-F-PCP, a Novel PCP Analog Ameliorates the Depressive-Like Behavior of Chronic Social Defeat Stress Mice via NMDA Receptor Antagonism

Long-term safety of ketamine and esketamine in treatment of depression

(2022) Sina Nikayin et al.   Expert Opinion On Drug Safety

R (−)-methoxetamine exerts rapid and sustained antidepressant effects and fewer behavioral side effects relative to S (+)-methoxetamine

(2021) Chrislean Jun Botanas et al.   NEUROPHARMACOLOGY

Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein

(2021) Raly James Perez Custodio et al.   Communications Biology

Advances in novel molecular targets for antidepressants

(2020) Qingzhong Wang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The role of dissociation in ketamine’s antidepressant effects

(2020) Elizabeth D. Ballard et al.   Nature Communications

The novel methoxetamine analogs N-ethylnorketamine hydrochloride (NENK), 2-MeO-N-ethylketamine hydrochloride (2-MeO-NEK), and 4-MeO-N-ethylketamine hydrochloride (4-MeO-NEK) elicit rapid antidepressant effects via activation of AMPA and 5-HT2 receptors

(2019) Leandro Val Sayson et al.   PSYCHOPHARMACOLOGY

Differences between ketamine’s short-term and long-term effects on brain circuitry in depression

(2019) Natalia Gass et al.   Translational Psychiatry

Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

(2019) Magdalena Miranda et al.   Frontiers in Cellular Neuroscience

Rodent ketamine depression-related research: Finding patterns in a literature of variability

(2019) Andrew J. Polis et al.   BEHAVIOURAL BRAIN RESEARCH

4-MeO-PCP and 3-MeO-PCMo, new dissociative drugs, produce rewarding and reinforcing effects through activation of mesolimbic dopamine pathway and alteration of accumbal CREB, deltaFosB, and BDNF levels

(2019) Arvie Abiero et al.   PSYCHOPHARMACOLOGY

Brain-Derived Neurotrophic Factor and Major Depressive Disorder: Evidence from Meta-Analyses

(2018) Taro Kishi et al.   Frontiers in Psychiatry

Involvement of extracellular signal-regulated kinase (ERK) in the short and long-lasting antidepressant-like activity of NMDA receptor antagonists (zinc and Ro 25-6981) in the forced swim test in rats

(2017) Bartłomiej Pochwat et al.   NEUROPHARMACOLOGY

Ketamine abuse potential and use disorder

(2016) Yu Liu et al.   BRAIN RESEARCH BULLETIN

New perspectives on the involvement of mTOR in depression as well as in the action of antidepressant drugs

(2016) Zuleide M. Ignácio et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Glutamate-Based Drug Discovery for Novel Antidepressants

(2016) Agnieszka Pałucha-Poniewiera et al.   Expert Opinion on Drug Discovery

Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects

(2016) G M I Chowdhury et al.   MOLECULAR PSYCHIATRY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

BDNF – a key transducer of antidepressant effects

(2016) Carl Björkholm et al.   NEUROPHARMACOLOGY

Excitatory amino acid transporters: Roles in glutamatergic neurotransmission

(2014) Christopher B. Divito et al.   NEUROCHEMISTRY INTERNATIONAL

What Did STAR*D Teach Us? Results From a Large-Scale, Practical, Clinical Trial for Patients With Depression

(2014) Bradley N. Gaynes et al.   PSYCHIATRIC SERVICES

Dissociable effects of the noncompetitive NMDA receptor antagonists ketamine and MK-801 on intracranial self-stimulation in rats

(2014) Todd M. Hillhouse et al.   PSYCHOPHARMACOLOGY

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

(2013) Undine E. Lang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neurocognitive effects of ketamine in treatment-resistant major depression: association with antidepressant response

(2013) James W. Murrough et al.   PSYCHOPHARMACOLOGY

Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases

(2012) Chien-Liang Glenn Lin et al.   Future Medicinal Chemistry

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

(2012) R. S. Duman et al.   SCIENCE

Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

(2011) Hiroyuki Koike et al.   BEHAVIOURAL BRAIN RESEARCH

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders

(2008) Gerard Sanacora et al.   NATURE REVIEWS DRUG DISCOVERY