The novel methoxetamine analogs N-ethylnorketamine hydrochloride (NENK), 2-MeO-N-ethylketamine hydrochloride (2-MeO-NEK), and 4-MeO-N-ethylketamine hydrochloride (4-MeO-NEK) elicit rapid antidepressant effects via activation of AMPA and 5-HT2 receptors
出版年份 2019 全文链接
标题
The novel methoxetamine analogs N-ethylnorketamine hydrochloride (NENK), 2-MeO-N-ethylketamine hydrochloride (2-MeO-NEK), and 4-MeO-N-ethylketamine hydrochloride (4-MeO-NEK) elicit rapid antidepressant effects via activation of AMPA and 5-HT2 receptors
作者
关键词
Depressive syndrome, NMDA receptor antagonists, Methoxetamine analogs, AMPA receptors, 5-HT<sub>2</sub> receptors
出版物
PSYCHOPHARMACOLOGY
Volume -, Issue -, Pages -
出版商
Springer Nature
发表日期
2019-04-17
DOI
10.1007/s00213-019-05219-x
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Intracellular Signaling Pathways Involved in ( S )- and ( R )-Ketamine Antidepressant Actions
- (2018) Panos Zanos et al. BIOLOGICAL PSYCHIATRY
- Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis
- (2018) Andrea Cipriani et al. LANCET
- The circadian gene, Per2 , influences methamphetamine sensitization and reward through the dopaminergic system in the striatum of mice
- (2018) Mikyung Kim et al. ADDICTION BIOLOGY
- Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism
- (2017) Lily R. Aleksandrova et al. JOURNAL OF PSYCHIATRY & NEUROSCIENCE
- Methoxetamine produces rapid and sustained antidepressant effects probably via glutamatergic and serotonergic mechanisms
- (2017) Chrislean Jun Botanas et al. NEUROPHARMACOLOGY
- Berberine produces antidepressant-like effects in ovariectomized mice
- (2017) Jie Fan et al. Scientific Reports
- The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex
- (2017) Wei Liu et al. NEURAL PLASTICITY
- A single dose of vortioxetine, but not ketamine or fluoxetine, increases plasticity-related gene expression in the rat frontal cortex
- (2016) Kristian Gaarn du Jardin et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- NMDAR inhibition-independent antidepressant actions of ketamine metabolites
- (2016) Panos Zanos et al. NATURE
- Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
- (2016) Ronald S Duman et al. NATURE MEDICINE
- Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test
- (2015) Phil Skolnick et al. ACTA NEUROPSYCHIATRICA
- Antidepressant actions of ketamine: from molecular mechanisms to clinical practice
- (2015) Lisa M Monteggia et al. CURRENT OPINION IN NEUROBIOLOGY
- A brief history of the development of antidepressant drugs: From monoamines to glutamate.
- (2015) Todd M. Hillhouse et al. EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
- Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway
- (2015) Francis L. Pazini et al. MOLECULAR NEUROBIOLOGY
- STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior
- (2015) Eryan Kong et al. Scientific Reports
- Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test
- (2015) Phil Skolnick et al. ACTA NEUROPSYCHIATRICA
- Age-dependent alterations of the NMDA receptor developmental profile and adult behavior in postnatally ketamine-treated mice
- (2014) Maryline Lecointre et al. Developmental Neurobiology
- NMDA antagonists under investigation for the treatment of major depressive disorder
- (2014) Bartłomiej Pochwat et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex
- (2013) W. Zhou et al. EUROPEAN PSYCHIATRY
- Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants
- (2013) Caroline A. Browne et al. Frontiers in Pharmacology
- Ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: Evidence for the involvement of the serotonergic system
- (2012) Ana Lúcia B. Zeni et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Methoxetamine: From drug of abuse to rapid-acting antidepressant
- (2012) M. Coppola et al. MEDICAL HYPOTHESES
- Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents
- (2012) Ronald S. Duman et al. TRENDS IN NEUROSCIENCES
- Acute administration of ketamine in rats increases hippocampal BDNF and mTOR levels during forced swimming test
- (2012) Chun Yang et al. UPSALA JOURNAL OF MEDICAL SCIENCES
- Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression
- (2011) Hiroyuki Koike et al. BEHAVIOURAL BRAIN RESEARCH
- Ketamine as a Novel Antidepressant: From Synapse to Behavior
- (2011) J W Murrough CLINICAL PHARMACOLOGY & THERAPEUTICS
- mTOR activation is required for the antidepressant effects of mGluR2/3 blockade
- (2011) Jason M. Dwyer et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
- (2011) Anita E. Autry et al. NATURE
- Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists
- (2011) Hiroyuki Koike et al. NEUROPHARMACOLOGY
- The mTOR signaling pathway in the prefrontal cortex is compromised in major depressive disorder
- (2011) Courtney S. Jernigan et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Antidepressant-like properties of α2-containing GABAA receptors
- (2010) Isabel Vollenweider et al. BEHAVIOURAL BRAIN RESEARCH
- Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat
- (2010) Yang Zhang et al. BRAIN RESEARCH
- Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
- (2010) Sébastien S. Hébert et al. HUMAN MOLECULAR GENETICS
- The role of glutamate on the action of antidepressants
- (2010) Kenji Hashimoto PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
- (2010) N. Li et al. SCIENCE
- Twenty-five years of quantitative PCR for gene expression analysis
- (2008) Heather D. VanGuilder et al. BIOTECHNIQUES
- Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors
- (2007) Sungho Maeng et al. BIOLOGICAL PSYCHIATRY
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